Infection with a newly designed dual fluorescent reporter HIV-1 effectively identifies latently infected CD4+ T cells

by Jinfeng Cai, Hongbo Gao, Jiacong Zhao, Shujing Hu, Xinyu Liang, Yanyan Yang, Zhuanglin Dai, Zhongsi Hong, Kai Deng
Published 2021-04-01

Alprazolam Prompts HIV-1 Transcriptional Reactivation and Enhances CTL Response Through RUNX1 Inhibition and STAT5 Activation

by Angel Lin, Angel Lin, Weam Othman Elbezanti, Weam Othman Elbezanti, Alexis Schirling, Alexis Schirling, Adel Ahmed, Rachel Van Duyne, Simon Cocklin, Zachary Klase, Zachary Klase
Published 2021-07-01

Compounds producing an effective combinatorial regimen for disruption of HIV‐1 latency

by Pargol Hashemi, Kris Barreto, Wendy Bernhard, Adam Lomness, Nicolette Honson, Tom A Pfeifer, P Richard Harrigan, Ivan Sadowski
Published 2018-02-01

Combination of a Latency-Reversing Agent With a Smac Mimetic Minimizes Secondary HIV-1 Infection in vitro

by Shin-ichiro Hattori, Kouki Matsuda, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Shinichi Oka, Kazuhisa Yoshimura, Hiroaki Mitsuya, Hiroaki Mitsuya, Kenji Maeda
Published 2018-09-01

Lnc(ing)RNAs to the “shock and kill” strategy for HIV-1 cure

by Saikat Boliar, David G. Russell
Published 2021-03-01

In vivo Effects of Romidepsin on T-Cell Activation, Apoptosis and Function in the BCN02 HIV-1 Kick&Kill Clinical Trial

by Miriam Rosás-Umbert, Miriam Rosás-Umbert, Marta Ruiz-Riol, Marco A. Fernández, Marta Marszalek, Pep Coll, Christian Manzardo, Samandhy Cedeño, José M. Miró, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, Bonaventura Clotet, Tomáš Hanke, Tomáš Hanke, José Moltó, José Moltó, Beatriz Mothe, Beatriz Mothe, Beatriz Mothe, Christian Brander, Christian Brander, Christian Brander, the BCN02 study group, Susana Benet, Christian Brander, Samandhy Cedeño, Bonaventura Clotet, Pep Coll, Anuksa Llano, Javier Martinez-Picado, Marta Marszalek, Sara Morón-López, Beatriz Mothe, Roger Paredes, Maria C. Puertas, Miriam Rosás-Umbert, Marta Ruiz-Riol, Roser Escrig, Silvia Gel, Miriam López, Cristina Miranda, José Moltó, Jose Muñoz, Nuria Perez-Alvarez, Jordi Puig, Boris Revollo, Jessica Toro, Ana Maria Barriocanal, Magi Farré, Cristina Perez-Reche, Marta Valle, Christian Manzardo, Juan Ambrosioni, Irene Ruiz, Cristina Rovira, Carmen Ligero, Jose M. Miro, Antonio Carrillo, Michael Meulbroek, Ferran Pujol, Jorge Saz, Nicola Borthwick, Alison Crook, Edmund G. Wee, Tomáš Hanke
Published 2020-03-01

The Effect of JAK1/2 Inhibitors on HIV Reservoir Using Primary Lymphoid Cell Model of HIV Latency

by Lesley R. de Armas, Christina Gavegnano, Christina Gavegnano, Christina Gavegnano, Suresh Pallikkuth, Stefano Rinaldi, Li Pan, Emilie Battivelli, Emilie Battivelli, Emilie Battivelli, Eric Verdin, Eric Verdin, Eric Verdin, Ramzi T. Younis, Rajendra Pahwa, Siôn L. Williams, Raymond F. Schinazi, Savita Pahwa
Published 2021-08-01

Benzotriazoles Reactivate Latent HIV-1 through Inactivation of STAT5 SUMOylation

by Alberto Bosque, Kyle A. Nilson, Amanda B. Macedo, Adam M. Spivak, Nancie M. Archin, Ryan M. Van Wagoner, Laura J. Martins, Camille L. Novis, Matthew A. Szaniawski, Chris M. Ireland, David M. Margolis, David H. Price, Vicente Planelles
Published 2017-01-01

Are BET Inhibitors yet Promising Latency-Reversing Agents for HIV-1 Reactivation in AIDS Therapy?

by Thanarat Salahong, Christian Schwartz, Rungroch Sungthong
Published 2021-05-01

CPI-637 as a Potential Bifunctional Latency-Reversing Agent That Targets Both the BRD4 and TIP60 Proteins

by Tengyi Zheng, Pei Chen, Yifan Huang, Jiayin Qiu, Chenliang Zhou, Ziyao Wu, Lin Li
Published 2021-07-01

Polyanionic carbosilane dendrimers as a new adjuvant in combination with latency reversal agents for HIV treatment

by Ignacio Relaño-Rodríguez, Raquel Juárez-Sánchez, Carolina Pavicic, Eduardo Muñoz, Maria Ángeles Muñoz-Fernández
Published 2019-05-01

Thalidomide is Associated With Increased T Cell Activation and Inflammation in Antiretroviral-naive HIV-infected Individuals in a Randomised Clinical Trial of Efficacy and Safety

by Tânia R.C. Vergara, Sadia Samer, Joanna R. Santos-Oliveira, Leila B. Giron, Muhammad Shoaib Arif, Maria Luciana Silva-Freitas, Lia A. Cherman, Mauro S. Treitsman, Alberto Chebabo, Maria Cecilia A. Sucupira, Alda M. Da-Cruz, Ricardo Sobhie Diaz
Published 2017-09-01

Experimental Systems for Measuring HIV Latency and Reactivation

by Koh Fujinaga, Daniele C. Cary
Published 2020-11-01

Small Molecule Inhibitors of BAF; A Promising Family of Compounds in HIV-1 Latency Reversal

by Mateusz Stoszko, Elisa De Crignis, Casper Rokx, Mir Mubashir Khalid, Cynthia Lungu, Robert-Jan Palstra, Tsung Wai Kan, Charles Boucher, Annelies Verbon, Emily C. Dykhuizen, Tokameh Mahmoudi
Published 2016-01-01

Current Status of Latency Reversing Agents Facing the Heterogeneity of HIV-1 Cellular and Tissue Reservoirs

by Amina Ait-Ammar, Anna Kula, Gilles Darcis, Roxane Verdikt, Stephane De Wit, Virginie Gautier, Patrick W. G. Mallon, Alessandro Marcello, Olivier Rohr, Carine Van Lint
Published 2020-01-01

HIV LTR-Driven Antisense RNA by Itself Has Regulatory Function and May Curtail Virus Reactivation From Latency

by Mie Kobayashi-Ishihara, Mie Kobayashi-Ishihara, Kazutaka Terahara, Javier P. Martinez, Makoto Yamagishi, Ryutaro Iwabuchi, Ryutaro Iwabuchi, Christian Brander, Christian Brander, Christian Brander, Manabu Ato, Manabu Ato, Toshiki Watanabe, Andreas Meyerhans, Andreas Meyerhans, Yasuko Tsunetsugu-Yokota, Yasuko Tsunetsugu-Yokota, Yasuko Tsunetsugu-Yokota
Published 2018-05-01

Targeting Cellular and Tissue HIV Reservoirs With Toll-Like Receptor Agonists

by Amanda B. Macedo, Camille L. Novis, Alberto Bosque
Published 2019-10-01

New Latency Reversing Agents for HIV-1 Cure: Insights from Nonhuman Primate Models

by Katherine M. Bricker, Ann Chahroudi, Maud Mavigner
Published 2021-08-01

Activation of the Anti-Oxidative Stress Response Reactivates Latent HIV-1 Through the Mitochondrial Antiviral Signaling Protein Isoform MiniMAVS

by Indra Sarabia, Camille L. Novis, Amanda B. Macedo, Hiroshi Takata, Racheal Nell, Juyeon C. Kakazu, Robert L. Furler, Binita Shakya, Heidi L. Schubert, Christopher P. Hill, Ana Beatriz DePaula-Silva, Adam M. Spivak, Lydie Trautmann, Vicente Planelles, Alberto Bosque
Published 2021-06-01

Coloring hidden viruses

by Marina Lusic
Published 2018-05-01