Deleterious alleles in the human genome are on average younger than neutral alleles of the same frequency.

by Adam Kiezun, Sara L Pulit, Laurent C Francioli, Freerk van Dijk, Morris Swertz, Dorret I Boomsma, Cornelia M van Duijn, P Eline Slagboom, G J B van Ommen, Cisca Wijmenga, Genome of the Netherlands Consortium, Paul I W de Bakker, Shamil R Sunyaev
Published 2013-01-01

Genetic variation in the renin—angiotensin system, use of renin—angiotensin system inhibitors and the risk of myocardial infarction

by Anke-Hilse Maitland-van der Zee, Diane BMA van Wieren-de Wijer, Anthonius de Boer, Abraham A Kroon, Peter W de Leeuw, Paul Schiffers, Rob GJH Janssen, Bruce M Psaty, Cornelia M van Duijn, Bruno HCh Stricker, Olaf H Klungel
Published 2011-09-01

Exome Sequencing Analysis Identifies Rare Variants in ATM and RPL8 That Are Associated With Shorter Telomere Length

by Ashley van der Spek, Ashley van der Spek, Sophie C. Warner, Linda Broer, Christopher P. Nelson, Christopher P. Nelson, Dina Vojinovic, Shahzad Ahmad, Pascal P. Arp, Rutger W. W. Brouwer, Matthew Denniff, Mirjam C. G. N. van den Hout, Jeroen G. J. van Rooij, Jeroen G. J. van Rooij, Robert Kraaij, Wilfred F. J. van IJcken, Nilesh J. Samani, Nilesh J. Samani, M. Arfan Ikram, André G. Uitterlinden, André G. Uitterlinden, Veryan Codd, Veryan Codd, Najaf Amin, Najaf Amin, Cornelia M. van Duijn, Cornelia M. van Duijn
Published 2020-04-01

Association of metformin, sulfonylurea and insulin use with brain structure and function and risk of dementia and Alzheimer's disease: Pooled analysis from 5 cohorts.

by Galit Weinstein, Kendra L Davis-Plourde, Sarah Conner, Jayandra J Himali, Alexa S Beiser, Anne Lee, Andreea M Rawlings, Sanaz Sedaghat, Jie Ding, Erin Moshier, Cornelia M van Duijn, Michal S Beeri, Elizabeth Selvin, M Arfan Ikram, Lenore J Launer, Mary N Haan, Sudha Seshadri
Published 2019-01-01

Human prion diseases in the Netherlands (1998-2009): clinical, genetic and molecular aspects.

by Casper Jansen, Piero Parchi, Sabina Capellari, Carla A Ibrahim-Verbaas, Maaike Schuur, Rosaria Strammiello, Patrizia Corrado, Matthew T Bishop, Willem A van Gool, Marcel M Verbeek, Frank Baas, Wesley van Saane, Wim G M Spliet, Gerard H Jansen, Cornelia M van Duijn, Annemieke J M Rozemuller
Published 2012-01-01

Limited overlap in significant hits between genome-wide association studies on two airflow obstruction definitions in the same population

by Diana A. van der Plaat, Judith M. Vonk, Lies Lahousse, Kim de Jong, Alen Faiz, Ivana Nedeljkovic, Najaf Amin, Cleo C. van Diemen, Guy G. Brusselle, Yohan Bossé, Corry-Anke Brandsma, Ke Hao, Peter D. Paré, Cornelia M. van Duijn, Dirkje S. Postma, H. Marike Boezen
Published 2019-03-01

Insight in genome-wide association of metabolite quantitative traits by exome sequence analyses.

by Ayşe Demirkan, Peter Henneman, Aswin Verhoeven, Harish Dharuri, Najaf Amin, Jan Bert van Klinken, Lennart C Karssen, Boukje de Vries, Axel Meissner, Sibel Göraler, Arn M J M van den Maagdenberg, André M Deelder, Peter A C 't Hoen, Cornelia M van Duijn, Ko Willems van Dijk
Published 2015-01-01

Lipidomic profiling identifies signatures of metabolic risk

by Xiaoyan Yin, Christine M. Willinger, Joshua Keefe, Jun Liu, Antonio Fernández-Ortiz, Borja Ibáñez, José Peñalvo, Aram Adourian, George Chen, Dolores Corella, Reinald Pamplona, Manuel Portero-Otin, Mariona Jove, Paul Courchesne, Cornelia M. van Duijn, Valentín Fuster, José M. Ordovás, Ayşe Demirkan, Martin G. Larson, Daniel Levy
Published 2020-01-01

Blood‐based metabolic signatures in Alzheimer's disease

by Francisca A. deLeeuw, Carel F.W. Peeters, Maartje I. Kester, Amy C. Harms, Eduard A. Struys, Thomas Hankemeier, Herman W.T. vanVlijmen, Sven J. van derLee, Cornelia M. vanDuijn, Philip Scheltens, Ayşe Demirkan, Mark A. van deWiel, Wiesje M. van derFlier, Charlotte E. Teunissen
Published 2017-01-01

Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels.

by Wilmar Igl, Asa Johansson, James F Wilson, Sarah H Wild, Ozren Polasek, Caroline Hayward, Veronique Vitart, Nicholas Hastie, Pavao Rudan, Carsten Gnewuch, Gerd Schmitz, Thomas Meitinger, Peter P Pramstaller, Andrew A Hicks, Ben A Oostra, Cornelia M van Duijn, Igor Rudan, Alan Wright, Harry Campbell, Ulf Gyllensten, EUROSPAN Consortium
Published 2010-01-01

Fine-mapping the genetic association of the major histocompatibility complex in multiple sclerosis: HLA and non-HLA effects.

by Nikolaos A Patsopoulos, Lisa F Barcellos, Rogier Q Hintzen, Catherine Schaefer, Cornelia M van Duijn, Janelle A Noble, Towfique Raj, IMSGC, ANZgene, Pierre-Antoine Gourraud, Barbara E Stranger, Jorge Oksenberg, Tomas Olsson, Bruce V Taylor, Stephen Sawcer, David A Hafler, Mary Carrington, Philip L De Jager, Paul I W de Bakker
Published 2013-11-01

The ERCC6 gene and age-related macular degeneration.

by Dominique C Baas, Dominiek D Despriet, Theo G M F Gorgels, Julie Bergeron-Sawitzke, André G Uitterlinden, Albert Hofman, Cornelia M van Duijn, Joanna E Merriam, R Theodore Smith, Gaetano R Barile, Jacoline B ten Brink, Johannes R Vingerling, Caroline C W Klaver, Rando Allikmets, Michael Dean, Arthur A B Bergen
Published 2010-11-01

Heritability of the shape of subcortical brain structures in the general population

by Gennady V. Roshchupkin, Boris A. Gutman, Meike W. Vernooij, Neda Jahanshad, Nicholas G. Martin, Albert Hofman, Katie L. McMahon, Sven J. van der Lee, Cornelia M. van Duijn, Greig I. de Zubicaray, André G. Uitterlinden, Margaret J. Wright, Wiro J. Niessen, Paul M. Thompson, M. Arfan Ikram, Hieab H. H. Adams
Published 2016-12-01

A combined linkage, microarray and exome analysis suggests MAP3K11 as a candidate gene for left ventricular hypertrophy

by Claudia Tamar Silva, Irina V. Zorkoltseva, Maartje N. Niemeijer, Marten E. van den Berg, Najaf Amin, Ayşe Demirkan, Elisa van Leeuwen, Adriana I. Iglesias, Laura B. Piñeros-Hernández, Carlos M. Restrepo, Jan A. Kors, Anatoly V. Kirichenko, Rob Willemsen, Ben A. Oostra, Bruno H. Stricker, André G. Uitterlinden, Tatiana I. Axenovich, Cornelia M. van Duijn, Aaron Isaacs
Published 2018-03-01

Genome-wide association study for acute otitis media in children identifies FNDC1 as disease contributing gene

by Gijs van Ingen, Jin Li, André Goedegebure, Rahul Pandey, Yun Rose Li, Michael E. March, Vincent W. V. Jaddoe, Marina Bakay, Frank D. Mentch, Kelly Thomas, Zhi Wei, Xiao Chang, Heather S. Hain, André G. Uitterlinden, Henriette A. Moll, Cornelia M. van Duijn, Fernando Rivadeneira, Hein Raat, Robert J. Baatenburg de Jong, Patrick M. Sleiman, Marc P. van der Schroeff, Hakon Hakonarson
Published 2016-09-01

Genome-wide identification of directed gene networks using large-scale population genomics data

by René Luijk, Koen F. Dekkers, Maarten van Iterson, Wibowo Arindrarto, Annique Claringbould, Paul Hop, Dorret I. Boomsma, Cornelia M. van Duijn, Marleen M. J. van Greevenbroek, Jan H. Veldink, Cisca Wijmenga, Lude Franke, Peter A. C. ’t Hoen, Rick Jansen, Joyce van Meurs, Hailiang Mei, P. Eline Slagboom, Bastiaan T. Heijmans, Erik W. van Zwet, BIOS (Biobank-based Integrative Omics Study) Consortium
Published 2018-08-01

A genome-wide association study of optic disc parameters.

by Wishal D Ramdas, Leonieke M E van Koolwijk, M Kamran Ikram, Nomdo M Jansonius, Paulus T V M de Jong, Arthur A B Bergen, Aaron Isaacs, Najaf Amin, Yurii S Aulchenko, Roger C W Wolfs, Albert Hofman, Fernando Rivadeneira, Ben A Oostra, Andre G Uitterlinden, Pirro Hysi, Christopher J Hammond, Hans G Lemij, Johannes R Vingerling, Caroline C W Klaver, Cornelia M van Duijn
Published 2010-06-01

Author Correction: Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

by Fiona A. Hagenbeek, René Pool, Jenny van Dongen, H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Published 2020-03-01

A cross-omics integrative study of metabolic signatures of chronic obstructive pulmonary disease

by Ivana Prokić, Lies Lahousse, Maaike de Vries, Jun Liu, Marita Kalaoja, Judith M. Vonk, Diana A. van der Plaat, Cleo C. van Diemen, Ashley van der Spek, Alexandra Zhernakova, Jingyuan Fu, Mohsen Ghanbari, Mika Ala-Korpela, Johannes Kettunen, Aki S. Havulinna, Markus Perola, Veikko Salomaa, Lars Lind, Johan Ärnlöv, Bruno H. C. Stricker, Guy G. Brusselle, H. Marike Boezen, Cornelia M. van Duijn, Najaf Amin
Published 2020-07-01

Heritability estimates for 361 blood metabolites across 40 genome-wide association studies

by Fiona A. Hagenbeek, René Pool, Jenny van Dongen, Harmen H. M. Draisma, Jouke Jan Hottenga, Gonneke Willemsen, Abdel Abdellaoui, Iryna O. Fedko, Anouk den Braber, Pieter Jelle Visser, Eco J. C. N. de Geus, Ko Willems van Dijk, Aswin Verhoeven, H. Eka Suchiman, Marian Beekman, P. Eline Slagboom, Cornelia M. van Duijn, BBMRI Metabolomics Consortium, Amy C. Harms, Thomas Hankemeier, Meike Bartels, Michel G. Nivard, Dorret I. Boomsma
Published 2020-01-01