Advances in de Novo Drug Design: From Conventional to Machine Learning Methods

by Varnavas D. Mouchlis, Antreas Afantitis, Angela Serra, Michele Fratello, Anastasios G. Papadiamantis, Vassilis Aidinis, Iseult Lynch, Dario Greco, Georgia Melagraki
Published 2021-02-01

Manually curated transcriptomics data collection for toxicogenomic assessment of engineered nanomaterials

by Laura Aliisa Saarimäki, Antonio Federico, Iseult Lynch, Anastasios G. Papadiamantis, Andreas Tsoumanis, Georgia Melagraki, Antreas Afantitis, Angela Serra, Dario Greco
Published 2021-02-01

Aging bone marrow mesenchymal stromal cells have altered membrane glycerophospholipid composition and functionality[S]

by Lotta Kilpinen, Feven Tigistu-Sahle, Sofia Oja, Dario Greco, Amarjit Parmar, Päivi Saavalainen, Janne Nikkilä, Matti Korhonen, Petri Lehenkari, Reijo Käkelä, Saara Laitinen
Published 2013-03-01

MiR-34a expression has an effect for lower risk of metastasis and associates with expression patterns predicting clinical outcome in breast cancer.

by Hanna Peurala, Dario Greco, Tuomas Heikkinen, Sippy Kaur, Jirina Bartkova, Maral Jamshidi, Kristiina Aittomäki, Päivi Heikkilä, Jiri Bartek, Carl Blomqvist, Ralf Bützow, Heli Nevanlinna
Published 2011-01-01

Expression of DAI by an oncolytic vaccinia virus boosts the immunogenicity of the virus and enhances antitumor immunity

by Mari Hirvinen, Cristian Capasso, Kilian Guse, Mariangela Garofalo, Andrea Vitale, Marko Ahonen, Lukasz Kuryk, Markus Vähä-Koskela, Akseli Hemminki, Vittorio Fortino, Dario Greco, Vincenzo Cerullo
Published 2016-01-01

Toxicogenomic Profiling of 28 Nanomaterials in Mouse Airways

by Pia A. S. Kinaret, Joseph Ndika, Marit Ilves, Henrik Wolff, Gerard Vales, Hannu Norppa, Kai Savolainen, Tiina Skoog, Juha Kere, Sergio Moya, Richard D. Handy, Piia Karisola, Bengt Fadeel, Dario Greco, Harri Alenius
Published 2021-05-01

Phosphorylation of NFATC1 at PIM1 target sites is essential for its ability to promote prostate cancer cell migration and invasion

by Sini K. Eerola, Niina M. Santio, Sanni Rinne, Petri Kouvonen, Garry L. Corthals, Mauro Scaravilli, Giovanni Scala, Angela Serra, Dario Greco, Pekka Ruusuvuori, Leena Latonen, Eeva-Marja Rainio, Tapio Visakorpi, Päivi J. Koskinen
Published 2019-11-01

DNA Methylation Levels in Mononuclear Leukocytes from the Mother and Her Child Are Associated with IgE Sensitization to Allergens in Early Life

by Nathalie Acevedo, Giovanni Scala, Simon Kebede Merid, Paolo Frumento, Sören Bruhn, Anna Andersson, Christoph Ogris, Matteo Bottai, Göran Pershagen, Gerard H. Koppelman, Erik Melén, Erik Sonnhammer, Johan Alm, Cilla Söderhäll, Juha Kere, Dario Greco, Annika Scheynius
Published 2021-01-01

Surface PEGylation suppresses pulmonary effects of CuO in allergen-induced lung inflammation

by Marit Ilves, Pia Anneli Sofia Kinaret, Joseph Ndika, Piia Karisola, Veer Marwah, Vittorio Fortino, Yuri Fedutik, Manuel Correia, Nicky Ehrlich, Katrin Loeschner, Alexandros Besinis, Joanne Vassallo, Richard D. Handy, Henrik Wolff, Kai Savolainen, Dario Greco, Harri Alenius
Published 2019-07-01

Transcriptomics in Toxicogenomics, Part I: Experimental Design, Technologies, Publicly Available Data, and Regulatory Aspects

by Pia Anneli Sofia Kinaret, Angela Serra, Antonio Federico, Pekka Kohonen, Penny Nymark, Irene Liampa, My Kieu Ha, Jang-Sik Choi, Karolina Jagiello, Natasha Sanabria, Georgia Melagraki, Luca Cattelani, Michele Fratello, Haralambos Sarimveis, Antreas Afantitis, Tae-Hyun Yoon, Mary Gulumian, Roland Grafström, Tomasz Puzyn, Dario Greco
Published 2020-04-01

IL-17/Th17 pathway is activated in acne lesions.

by Hanna-Leena Kelhälä, Riitta Palatsi, Nanna Fyhrquist, Sari Lehtimäki, Juha P Väyrynen, Matti Kallioinen, Minna E Kubin, Dario Greco, Kaisa Tasanen, Harri Alenius, Beatrice Bertino, Isabelle Carlavan, Bruno Mehul, Sophie Déret, Pascale Reiniche, Philippe Martel, Carine Marty, Ulrike Blume-Peytavi, Johannes J Voegel, Antti Lauerma
Published 2014-01-01

Transcriptomics in Toxicogenomics, Part II: Preprocessing and Differential Expression Analysis for High Quality Data

by Antonio Federico, Angela Serra, My Kieu Ha, Pekka Kohonen, Jang-Sik Choi, Irene Liampa, Penny Nymark, Natasha Sanabria, Luca Cattelani, Michele Fratello, Pia Anneli Sofia Kinaret, Karolina Jagiello, Tomasz Puzyn, Georgia Melagraki, Mary Gulumian, Antreas Afantitis, Haralambos Sarimveis, Tae-Hyun Yoon, Roland Grafström, Dario Greco
Published 2020-05-01

Transcriptomics in Toxicogenomics, Part III: Data Modelling for Risk Assessment

by Angela Serra, Michele Fratello, Luca Cattelani, Irene Liampa, Georgia Melagraki, Pekka Kohonen, Penny Nymark, Antonio Federico, Pia Anneli Sofia Kinaret, Karolina Jagiello, My Kieu Ha, Jang-Sik Choi, Natasha Sanabria, Mary Gulumian, Tomasz Puzyn, Tae-Hyun Yoon, Haralambos Sarimveis, Roland Grafström, Antreas Afantitis, Dario Greco
Published 2020-04-01

Multiparametric Profiling of Engineered Nanomaterials: Unmasking the Surface Coating Effect

by Audrey Gallud, Mathilde Delaval, Pia Kinaret, Veer Singh Marwah, Vittorio Fortino, Jimmy Ytterberg, Roman Zubarev, Tiina Skoog, Juha Kere, Manuel Correia, Katrin Loeschner, Zahraa Al‐Ahmady, Kostas Kostarelos, Jaime Ruiz, Didier Astruc, Marco Monopoli, Richard Handy, Sergio Moya, Kai Savolainen, Harri Alenius, Dario Greco, Bengt Fadeel
Published 2020-11-01

miR-34b/c Regulates Wnt1 and Enhances Mesencephalic Dopaminergic Neuron Differentiation

by Roberto De Gregorio, Salvatore Pulcrano, Claudia De Sanctis, Floriana Volpicelli, Ezia Guatteo, Lars von Oerthel, Emanuele Claudio Latagliata, Roberta Esposito, Rosa Maria Piscitelli, Carla Perrone-Capano, Valerio Costa, Dario Greco, Stefano Puglisi-Allegra, Marten P. Smidt, Umberto di Porzio, Massimiliano Caiazzo, Nicola Biagio Mercuri, Meng Li, Gian Carlo Bellenchi
Published 2018-04-01

Can an InChI for Nano Address the Need for a Simplified Representation of Complex Nanomaterials across Experimental and Nanoinformatics Studies?

by Iseult Lynch, Antreas Afantitis, Thomas Exner, Martin Himly, Vladimir Lobaskin, Philip Doganis, Dieter Maier, Natasha Sanabria, Anastasios G. Papadiamantis, Anna Rybinska-Fryca, Maciej Gromelski, Tomasz Puzyn, Egon Willighagen, Blair D. Johnston, Mary Gulumian, Marianne Matzke, Amaia Green Etxabe, Nathan Bossa, Angela Serra, Irene Liampa, Stacey Harper, Kaido Tämm, Alexander CØ Jensen, Pekka Kohonen, Luke Slater, Andreas Tsoumanis, Dario Greco, David A. Winkler, Haralambos Sarimveis, Georgia Melagraki
Published 2020-12-01

Microbe-host interplay in atopic dermatitis and psoriasis

by Nanna Fyhrquist, Gareth Muirhead, Stefanie Prast-Nielsen, Marine Jeanmougin, Peter Olah, Tiina Skoog, Gerome Jules-Clement, Micha Feld, Mauricio Barrientos-Somarribas, Hanna Sinkko, Ellen H. van den Bogaard, Patrick L.J.M. Zeeuwen, Gijs Rikken, Joost Schalkwijk, Hanna Niehues, Walter Däubener, Silvia Kathrin Eller, Helen Alexander, Davide Pennino, Sari Suomela, Ioannis Tessas, Emilia Lybeck, Anna M. Baran, Hamid Darban, Roopesh Singh Gangwar, Ulrich Gerstel, Katharina Jahn, Piia Karisola, Lee Yan, Britta Hansmann, Shintaro Katayama, Stephan Meller, Max Bylesjö, Philippe Hupé, Francesca Levi-Schaffer, Dario Greco, Annamari Ranki, Jens M. Schröder, Jonathan Barker, Juha Kere, Sophia Tsoka, Antti Lauerma, Vassili Soumelis, Frank O. Nestle, Bernhard Homey, Björn Andersson, Harri Alenius
Published 2019-10-01

NanoSolveIT Project: Driving nanoinformatics research to develop innovative and integrated tools for in silico nanosafety assessment

by Antreas Afantitis, Georgia Melagraki, Panagiotis Isigonis, Andreas Tsoumanis, Dimitra Danai Varsou, Eugenia Valsami-Jones, Anastasios Papadiamantis, Laura-Jayne A. Ellis, Haralambos Sarimveis, Philip Doganis, Pantelis Karatzas, Periklis Tsiros, Irene Liampa, Vladimir Lobaskin, Dario Greco, Angela Serra, Pia Anneli Sofia Kinaret, Laura Aliisa Saarimäki, Roland Grafström, Pekka Kohonen, Penny Nymark, Egon Willighagen, Tomasz Puzyn, Anna Rybinska-Fryca, Alexander Lyubartsev, Keld Alstrup Jensen, Jan Gerit Brandenburg, Stephen Lofts, Claus Svendsen, Samuel Harrison, Dieter Maier, Kaido Tamm, Jaak Jänes, Lauri Sikk, Maria Dusinska, Eleonora Longhin, Elise Rundén-Pran, Espen Mariussen, Naouale El Yamani, Wolfgang Unger, Jörg Radnik, Alexander Tropsha, Yoram Cohen, Jerzy Leszczynski, Christine Ogilvie Hendren, Mark Wiesner, David Winkler, Noriyuki Suzuki, Tae Hyun Yoon, Jang-Sik Choi, Natasha Sanabria, Mary Gulumian, Iseult Lynch
Published 2020-01-01

MicroRNA related polymorphisms and breast cancer risk.

by Sofia Khan, Dario Greco, Kyriaki Michailidou, Roger L Milne, Taru A Muranen, Tuomas Heikkinen, Kirsimari Aaltonen, Joe Dennis, Manjeet K Bolla, Jianjun Liu, Per Hall, Astrid Irwanto, Keith Humphreys, Jingmei Li, Kamila Czene, Jenny Chang-Claude, Rebecca Hein, Anja Rudolph, Petra Seibold, Dieter Flesch-Janys, Olivia Fletcher, Julian Peto, Isabel dos Santos Silva, Nichola Johnson, Lorna Gibson, Zoe Aitken, John L Hopper, Helen Tsimiklis, Minh Bui, Enes Makalic, Daniel F Schmidt, Melissa C Southey, Carmel Apicella, Jennifer Stone, Quinten Waisfisz, Hanne Meijers-Heijboer, Muriel A Adank, Rob B van der Luijt, Alfons Meindl, Rita K Schmutzler, Bertram Müller-Myhsok, Peter Lichtner, Clare Turnbull, Nazneen Rahman, Stephen J Chanock, David J Hunter, Angela Cox, Simon S Cross, Malcolm W R Reed, Marjanka K Schmidt, Annegien Broeks, Laura J Van't Veer, Frans B Hogervorst, Peter A Fasching, Michael G Schrauder, Arif B Ekici, Matthias W Beckmann, Stig E Bojesen, Børge G Nordestgaard, Sune F Nielsen, Henrik Flyger, Javier Benitez, Pilar M Zamora, Jose I A Perez, Christopher A Haiman, Brian E Henderson, Fredrick Schumacher, Loic Le Marchand, Paul D P Pharoah, Alison M Dunning, Mitul Shah, Robert Luben, Judith Brown, Fergus J Couch, Xianshu Wang, Celine Vachon, Janet E Olson, Diether Lambrechts, Matthieu Moisse, Robert Paridaens, Marie-Rose Christiaens, Pascal Guénel, Thérèse Truong, Pierre Laurent-Puig, Claire Mulot, Frederick Marme, Barbara Burwinkel, Andreas Schneeweiss, Christof Sohn, Elinor J Sawyer, Ian Tomlinson, Michael J Kerin, Nicola Miller, Irene L Andrulis, Julia A Knight, Sandrine Tchatchou, Anna Marie Mulligan, Thilo Dörk, Natalia V Bogdanova, Natalia N Antonenkova, Hoda Anton-Culver, Hatef Darabi, Mikael Eriksson, Montserrat Garcia-Closas, Jonine Figueroa, Jolanta Lissowska, Louise Brinton, Peter Devilee, Robert A E M Tollenaar, Caroline Seynaeve, Christi J van Asperen, Vessela N Kristensen, kConFab Investigators, Australian Ovarian Cancer Study Group, Susan Slager, Amanda E Toland, Christine B Ambrosone, Drakoulis Yannoukakos, Annika Lindblom, Sara Margolin, Paolo Radice, Paolo Peterlongo, Monica Barile, Paolo Mariani, Maartje J Hooning, John W M Martens, J Margriet Collée, Agnes Jager, Anna Jakubowska, Jan Lubinski, Katarzyna Jaworska-Bieniek, Katarzyna Durda, Graham G Giles, Catriona McLean, Hiltrud Brauch, Thomas Brüning, Yon-Dschun Ko, GENICA Network, Hermann Brenner, Aida Karina Dieffenbach, Volker Arndt, Christa Stegmaier, Anthony Swerdlow, Alan Ashworth, Nick Orr, Michael Jones, Jacques Simard, Mark S Goldberg, France Labrèche, Martine Dumont, Robert Winqvist, Katri Pylkäs, Arja Jukkola-Vuorinen, Mervi Grip, Vesa Kataja, Veli-Matti Kosma, Jaana M Hartikainen, Arto Mannermaa, Ute Hamann, Georgia Chenevix-Trench, Carl Blomqvist, Kristiina Aittomäki, Douglas F Easton, Heli Nevanlinna
Published 2014-01-01