Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation.

by Dominik Hotter, Teresa Krabbe, Elisabeth Reith, Ali Gawanbacht, Nadia Rahm, Ahidjo Ayouba, Benoît Van Driessche, Carine Van Lint, Martine Peeters, Frank Kirchhoff, Daniel Sauter
Published 2017-08-01

Split-cre complementation indicates coincident activity of different genes in vivo.

by Johannes Hirrlinger, Anja Scheller, Petra G Hirrlinger, Beate Kellert, Wannan Tang, Michael C Wehr, Sandra Goebbels, Andreas Reichenbach, Rolf Sprengel, Moritz J Rossner, Frank Kirchhoff
Published 2009-01-01

Influence of methylene blue on microglia-induced inflammation and motor neuron degeneration in the SOD1(G93A) model for ALS.

by Payam Dibaj, Jana Zschüntzsch, Heinz Steffens, Jörg Scheffel, Bettina Göricke, Jochen H Weishaupt, Karim Le Meur, Frank Kirchhoff, Uwe-Karsten Hanisch, Eike D Schomburg, Clemens Neusch
Published 2012-01-01

Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2

by Kristina Hopfensperger, Jonathan Richard, Christina M. Stürzel, Frederic Bibollet-Ruche, Richard Apps, Marie Leoz, Jean-Christophe Plantier, Beatrice H. Hahn, Andrés Finzi, Frank Kirchhoff, Daniel Sauter
Published 2020-07-01

Endogenous TRIM5α Function Is Regulated by SUMOylation and Nuclear Sequestration for Efficient Innate Sensing in Dendritic Cells

by Débora M. Portilho, Juliette Fernandez, Mathieu Ringeard, Anthony K. Machado, Aude Boulay, Martha Mayer, Michaela Müller-Trutwin, Anne-Sophie Beignon, Frank Kirchhoff, Sébastien Nisole, Nathalie J. Arhel
Published 2016-01-01

An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins

by Matteo Bosso, Christina M. Stürzel, Dorota Kmiec, Smitha Srinivasachar Badarinarayan, Elisabeth Braun, Jumpei Ito, Kei Sato, Beatrice H. Hahn, Konstantin M.J. Sparrer, Daniel Sauter, Frank Kirchhoff
Published 2021-09-01

Angiotensin-Receptor-Associated Protein Modulates Ca2+ Signals in Photoreceptor and Mossy Fiber cells

by Rene Barro-Soria, Alejandro Caicedo, Herbert Jägle, Laura Merkel, Na Zhao, Gabriel Knop, Kaspar Gierke, Andrea Dannullis, Hayo Castrop, Johann Helmut Brandstätter, Frank Kirchhoff, Andreas Feigenspan, Olaf Strauß
Published 2019-12-01

Modest attenuation of HIV-1 Vpu alleles derived from elite controller plasma.

by Jingyan Chen, Nadine Tibroni, Daniel Sauter, Johanna Galaski, Toshiyuki Miura, Galit Alter, Birthe Mueller, Claudia Haller, Bruce D Walker, Frank Kirchhoff, Zabrina L Brumme, Takamasa Ueno, Oliver T Fackler
Published 2015-01-01

HIV Triggers a cGAS-Dependent, Vpu- and Vpr-Regulated Type I Interferon Response in CD4+ T Cells

by Jolien Vermeire, Ferdinand Roesch, Daniel Sauter, Réjane Rua, Dominik Hotter, Anouk Van Nuffel, Hanne Vanderstraeten, Evelien Naessens, Veronica Iannucci, Alessia Landi, Wojciech Witkowski, Ann Baeyens, Frank Kirchhoff, Bruno Verhasselt
Published 2016-10-01

Computational modeling and experimental validation of the EPI-X4/CXCR4 complex allows rational design of small peptide antagonists

by Pandian Sokkar, Mirja Harms, Christina Stürzel, Andrea Gilg, Gönül Kizilsavas, Martina Raasholm, Nico Preising, Manfred Wagner, Frank Kirchhoff, Ludger Ständker, Gilbert Weidinger, Benjamin Mayer, Jan Münch, Elsa Sanchez-Garcia
Published 2021-09-01

Influenza A virus does not encode a tetherin antagonist with Vpu-like activity and induces IFN-dependent tetherin expression in infected cells.

by Michael Winkler, Stephanie Bertram, Kerstin Gnirß, Inga Nehlmeier, Ali Gawanbacht, Frank Kirchhoff, Christina Ehrhardt, Stephan Ludwig, Miriam Kiene, Anna-Sophie Moldenhauer, Ulrike Goedecke, Christina B Karsten, Annika Kühl, Stefan Pöhlmann
Published 2012-01-01

CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein

by Dorota Kmiec, Rayhane Nchioua, Scott Sherrill-Mix, Christina M. Stürzel, Elena Heusinger, Elisabeth Braun, Marcos V. P. Gondim, Dominik Hotter, Konstantin M. J. Sparrer, Beatrice H. Hahn, Daniel Sauter, Frank Kirchhoff
Published 2020-01-01

A trip down memory lane with Retrovirology

by Monsef Benkirane, Ben Berkhout, Persephone Borrow, Ariberto Fassati, Masahiro Fujii, J. Victor Garcia-Martinez, D. Margolis, Monique Nijhuis, Leslie Parent, Klaus Strebel, François Venter, Frank Kirchhoff, Andrew Lever, Susan Ross, Johnson Mak
Published 2019-08-01

Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication.

by Carsten Frühbeis, Dominik Fröhlich, Wen Ping Kuo, Jesa Amphornrat, Sebastian Thilemann, Aiman S Saab, Frank Kirchhoff, Wiebke Möbius, Sandra Goebbels, Klaus-Armin Nave, Anja Schneider, Mikael Simons, Matthias Klugmann, Jacqueline Trotter, Eva-Maria Krämer-Albers
Published 2013-07-01

Differential Regulation of NF-κB-Mediated Proviral and Antiviral Host Gene Expression by Primate Lentiviral Nef and Vpu Proteins

by Daniel Sauter, Dominik Hotter, Benoît Van Driessche, Christina M. Stürzel, Silvia F. Kluge, Steffen Wildum, Hangxing Yu, Bernd Baumann, Thomas Wirth, Jean-Christophe Plantier, Marie Leoz, Beatrice H. Hahn, Carine Van Lint, Frank Kirchhoff
Published 2015-02-01

HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses

by Simon Langer, Christian Hammer, Kristina Hopfensperger, Lukas Klein, Dominik Hotter, Paul D De Jesus, Kristina M Herbert, Lars Pache, Nikaïa Smith, Johannes A van der Merwe, Sumit K Chanda, Jacques Fellay, Frank Kirchhoff, Daniel Sauter
Published 2019-02-01

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue.

by Dorota Kmiec, Bengisu Akbil, Swetha Ananth, Dominik Hotter, Konstantin M J Sparrer, Christina M Stürzel, Birthe Trautz, Ahidjo Ayouba, Martine Peeters, Zhong Yao, Igor Stagljar, Vânia Passos, Thomas Zillinger, Christine Goffinet, Daniel Sauter, Oliver T Fackler, Frank Kirchhoff
Published 2018-08-01

Human tetherin exerts strong selection pressure on the HIV-1 group N Vpu protein.

by Daniel Sauter, Daniel Unterweger, Michael Vogl, Shariq M Usmani, Anke Heigele, Silvia F Kluge, Elisabeth Hermkes, Markus Moll, Edward Barker, Martine Peeters, Gerald H Learn, Frederic Bibollet-Ruche, Joëlle V Fritz, Oliver T Fackler, Beatrice H Hahn, Frank Kirchhoff
Published 2012-12-01

Uninfected Bystander Cells Impact the Measurement of HIV-Specific Antibody-Dependent Cellular Cytotoxicity Responses

by Jonathan Richard, Jéréémie Prééévost, Amy E. Baxter, Benjamin von Bredow, Shilei Ding, Halima Medjahed, Gloria G. Delgado, Nathalie Brassard, Christina M. Sturzel, Frank Kirchhoff, Beatrice H. Hahn, Matthew S. Parsons, Daniel E. Kaufmann, David T. Evans, Andréééés Finzi, Stephen P. Goff
Published 2018-03-01

Nuclear PYHIN proteins target the host transcription factor Sp1 thereby restricting HIV-1 in human macrophages and CD4+ T cells.

by Matteo Bosso, Caterina Prelli Bozzo, Dominik Hotter, Meta Volcic, Christina M Stürzel, Annika Rammelt, Yi Ni, Stephan Urban, Miriam Becker, Mario Schelhaas, Sabine Wittmann, Maria H Christensen, Florian I Schmidt, Thomas Gramberg, Konstantin M J Sparrer, Daniel Sauter, Frank Kirchhoff
Published 2020-08-01