Nef-Mediated CD3-TCR Downmodulation Dampens Acute Inflammation and Promotes SIV Immune Evasion

by Simone Joas, Ulrike Sauermann, Berit Roshani, Antonina Klippert, Maria Daskalaki, Kerstin Mätz-Rensing, Nicole Stolte-Leeb, Anke Heigele, Gregory K. Tharp, Prachi Mehrotra Gupta, Sydney Nelson, Steven Bosinger, Laura Parodi, Luis Giavedoni, Guido Silvestri, Daniel Sauter, Christiane Stahl-Hennig, Frank Kirchhoff
Published 2020-02-01

An optimized derivative of an endogenous CXCR4 antagonist prevents atopic dermatitis and airway inflammation

by Mirja Harms, Monica M.W. Habib, Simona Nemska, Antonella Nicolò, Andrea Gilg, Nico Preising, Pandian Sokkar, Sara Carmignani, Martina Raasholm, Gilbert Weidinger, Gönül Kizilsavas, Manfred Wagner, Ludger Ständker, Ashraf H. Abadi, Hassan Jumaa, Frank Kirchhoff, Nelly Frossard, Elsa Sanchez-Garcia, Jan Münch
Published 2021-09-01

Activity-dependent switch of GABAergic inhibition into glutamatergic excitation in astrocyte-neuron networks

by Gertrudis Perea, Ricardo Gómez, Sara Mederos, Ana Covelo, Jesús J Ballesteros, Laura Schlosser, Alicia Hernández-Vivanco, Mario Martín-Fernández, Ruth Quintana, Abdelrahman Rayan, Adolfo Díez, Marco Fuenzalida, Amit Agarwal, Dwight E Bergles, Bernhard Bettler, Denise Manahan-Vaughan, Eduardo D Martín, Frank Kirchhoff, Alfonso Araque
Published 2016-12-01

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

by Shuai Xia, Qiaoshuai Lan, Yun Zhu, Chao Wang, Wei Xu, Yutang Li, Lijue Wang, Fanke Jiao, Jie Zhou, Chen Hua, Qian Wang, Xia Cai, Yang Wu, Jie Gao, Huan Liu, Ge Sun, Jan Münch, Frank Kirchhoff, Zhenghong Yuan, Youhua Xie, Fei Sun, Shibo Jiang, Lu Lu
Published 2021-07-01

Upregulation of BST-2 by Type I Interferons Reduces the Capacity of Vpu To Protect HIV-1-Infected Cells from NK Cell Responses

by Jérémie Prévost, Suzanne Pickering, Mitchell J. Mumby, Halima Medjahed, Gabrielle Gendron-Lepage, Gloria G. Delgado, Brennan S. Dirk, Jimmy D. Dikeakos, Christina M. Stürzel, Daniel Sauter, Frank Kirchhoff, Frederic Bibollet-Ruche, Beatrice H. Hahn, Mathieu Dubé, Daniel E. Kaufmann, Stuart J. D. Neil, Andrés Finzi, Jonathan Richard
Published 2019-06-01

SIV-induced terminally differentiated adaptive NK cells in lymph nodes associated with enhanced MHC-E restricted activity

by Nicolas Huot, Philippe Rascle, Caroline Petitdemange, Vanessa Contreras, Christina M. Stürzel, Eduard Baquero, Justin L. Harper, Caroline Passaes, Rachel Legendre, Hugo Varet, Yoann Madec, Ulrike Sauermann, Christiane Stahl-Hennig, Jacob Nattermann, Asier Saez-Cirion, Roger Le Grand, R. Keith Reeves, Mirko Paiardini, Frank Kirchhoff, Beatrice Jacquelin, Michaela Müller-Trutwin
Published 2021-02-01

Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins

by Elisabeth Braun, Dominik Hotter, Lennart Koepke, Fabian Zech, Rüdiger Groß, Konstantin M.J. Sparrer, Janis A. Müller, Christian K. Pfaller, Elena Heusinger, Rebecka Wombacher, Kathrin Sutter, Ulf Dittmer, Michael Winkler, Graham Simmons, Martin R. Jakobsen, Karl-Klaus Conzelmann, Stefan Pöhlmann, Jan Münch, Oliver T. Fackler, Frank Kirchhoff, Daniel Sauter
Published 2019-05-01

Repeated semen exposure decreases cervicovaginal SIVmac251 infection in rhesus macaques

by Shaheed A. Abdulhaqq, Melween Martinez, Guobin Kang, Idia V. Rodriguez, Stephanie M. Nichols, David Beaumont, Jocelin Joseph, Livio Azzoni, Xiangfan Yin, Megan Wise, David Weiner, Qin Liu, Andrea Foulkes, Jan Münch, Frank Kirchhoff, Christos Coutifaris, Georgia D. Tomaras, Carlos Sariol, Preston A. Marx, Qingsheng Li, Edmundo N. Kraiselburd, Luis J. Montaner
Published 2019-08-01

Semen amyloids participate in spermatozoa selection and clearance

by Nadia R Roan, Nathallie Sandi-Monroy, Nargis Kohgadai, Shariq M Usmani, Katherine G Hamil, Jason Neidleman, Mauricio Montano, Ludger Ständker, Annika Röcker, Marielle Cavrois, Jared Rosen, Kara Marson, James F Smith, Christopher D Pilcher, Friedrich Gagsteiger, Olena Sakk, Michael O’Rand, Polina V Lishko, Frank Kirchhoff, Jan Münch, Warner C Greene
Published 2017-06-01

Limited HIV infection of central memory and stem cell memory CD4+ T cells is associated with lack of progression in viremic individuals.

by Nichole R Klatt, Steven E Bosinger, Melicent Peck, Laura E Richert-Spuhler, Anke Heigele, Jillian P Gile, Nirav Patel, Jessica Taaffe, Boris Julg, David Camerini, Carlo Torti, Jeffrey N Martin, Steven G Deeks, Elizabeth Sinclair, Frederick M Hecht, Michael M Lederman, Mirko Paiardini, Frank Kirchhoff, Jason M Brenchley, Peter W Hunt, Guido Silvestri
Published 2014-08-01

The HIV-1 Env gp120 Inner Domain Shapes the Phe43 Cavity and the CD4 Binding Site

by Jérémie Prévost, William D. Tolbert, Halima Medjahed, Rebekah T. Sherburn, Navid Madani, Daria Zoubchenok, Gabrielle Gendron-Lepage, Althea E. Gaffney, Melissa C. Grenier, Sharon Kirk, Natasha Vergara, Changze Han, Brendan T. Mann, Agnès L. Chénine, Adel Ahmed, Irwin Chaiken, Frank Kirchhoff, Beatrice H. Hahn, Hillel Haim, Cameron F. Abrams, Amos B. Smith, Joseph Sodroski, Marzena Pazgier, Andrés Finzi
Published 2020-05-01

Species-specific host factors rather than virus-intrinsic virulence determine primate lentiviral pathogenicity

by Simone Joas, Erica H. Parrish, Clement W. Gnanadurai, Edina Lump, Christina M. Stürzel, Nicholas F. Parrish, Gerald H. Learn, Ulrike Sauermann, Berit Neumann, Kerstin Mätz Rensing, Dietmar Fuchs, James M. Billingsley, Steven E. Bosinger, Guido Silvestri, Cristian Apetrei, Nicolas Huot, Thalia Garcia-Tellez, Michaela Müller-Trutwin, Dominik Hotter, Daniel Sauter, Christiane Stahl-Hennig, Beatrice H. Hahn, Frank Kirchhoff
Published 2018-04-01

Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities

by Manuel Hayn, Maximilian Hirschenberger, Lennart Koepke, Rayhane Nchioua, Jan Hendrik Straub, Susanne Klute, Victoria Hunszinger, Fabian Zech, Caterina Prelli Bozzo, Wasim Aftab, Maria Hønholt Christensen, Carina Conzelmann, Janis Alexander Müller, Smitha Srinivasachar Badarinarayan, Christina Martina Stürzel, Ignasi Forne, Steffen Stenger, Karl-Klaus Conzelmann, Jan Münch, Florian Ingo Schmidt, Daniel Sauter, Axel Imhof, Frank Kirchhoff, Konstantin Maria Johannes Sparrer
Published 2021-05-01

A Placenta Derived C-Terminal Fragment of β-Hemoglobin With Combined Antibacterial and Antiviral Activity

by Rüdiger Groß, Richard Bauer, Franziska Krüger, Elke Rücker-Braun, Lia-Raluca Olari, Ludger Ständker, Nico Preising, Armando A. Rodríguez, Armando A. Rodríguez, Carina Conzelmann, Fabian Gerbl, Daniel Sauter, Frank Kirchhoff, Benjamin Hagemann, Jasmina Gačanin, Jasmina Gačanin, Tanja Weil, Tanja Weil, Yasser B. Ruiz-Blanco, Elsa Sanchez-Garcia, Wolf-Georg Forssmann, Annette Mankertz, Sabine Santibanez, Steffen Stenger, Paul Walther, Sebastian Wiese, Barbara Spellerberg, Jan Münch, Jan Münch
Published 2020-04-01

IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro

by Caterina Prelli Bozzo, Rayhane Nchioua, Meta Volcic, Lennart Koepke, Jana Krüger, Desiree Schütz, Sandra Heller, Christina M. Stürzel, Dorota Kmiec, Carina Conzelmann, Janis Müller, Fabian Zech, Elisabeth Braun, Rüdiger Groß, Lukas Wettstein, Tatjana Weil, Johanna Weiß, Federica Diofano, Armando A. Rodríguez Alfonso, Sebastian Wiese, Daniel Sauter, Jan Münch, Christine Goffinet, Alberto Catanese, Michael Schön, Tobias M. Boeckers, Steffen Stenger, Kei Sato, Steffen Just, Alexander Kleger, Konstantin M. J. Sparrer, Frank Kirchhoff
Published 2021-07-01

A molecular tweezer antagonizes seminal amyloids and HIV infection

by Edina Lump, Laura M Castellano, Christoph Meier, Janine Seeliger, Nelli Erwin, Benjamin Sperlich, Christina M Stürzel, Shariq Usmani, Rebecca M Hammond, Jens von Einem, Gisa Gerold, Florian Kreppel, Kenny Bravo-Rodriguez, Thomas Pietschmann, Veronica M Holmes, David Palesch, Onofrio Zirafi, Drew Weissman, Andrea Sowislok, Burkhard Wettig, Christian Heid, Frank Kirchhoff, Tanja Weil, Frank-Gerrit Klärner, Thomas Schrader, Gal Bitan, Elsa Sanchez-Garcia, Roland Winter, James Shorter, Jan Münch
Published 2015-08-01

Alpha-1 antitrypsin inhibits TMPRSS2 protease activity and SARS-CoV-2 infection

by Lukas Wettstein, Tatjana Weil, Carina Conzelmann, Janis A. Müller, Rüdiger Groß, Maximilian Hirschenberger, Alina Seidel, Susanne Klute, Fabian Zech, Caterina Prelli Bozzo, Nico Preising, Giorgio Fois, Robin Lochbaum, Philip Maximilian Knaff, Volker Mailänder, Ludger Ständker, Dietmar Rudolf Thal, Christian Schumann, Steffen Stenger, Alexander Kleger, Günter Lochnit, Benjamin Mayer, Yasser B. Ruiz-Blanco, Markus Hoffmann, Konstantin M. J. Sparrer, Stefan Pöhlmann, Elsa Sanchez-Garcia, Frank Kirchhoff, Manfred Frick, Jan Münch
Published 2021-03-01

Discovery and Characterization of an Endogenous CXCR4 Antagonist

by Onofrio Zirafi, Kyeong-Ae Kim, Ludger Ständker, Katharina B. Mohr, Daniel Sauter, Anke Heigele, Silvia F. Kluge, Eliza Wiercinska, Doreen Chudziak, Rudolf Richter, Barbara Moepps, Peter Gierschik, Virag Vas, Hartmut Geiger, Markus Lamla, Tanja Weil, Timo Burster, Andreas Zgraja, Francois Daubeuf, Nelly Frossard, Muriel Hachet-Haas, Fabian Heunisch, Christoph Reichetzeder, Jean-Luc Galzi, Javier Pérez-Castells, Angeles Canales-Mayordomo, Jesus Jiménez-Barbero, Guillermo Giménez-Gallego, Marion Schneider, James Shorter, Amalio Telenti, Berthold Hocher, Wolf-Georg Forssmann, Halvard Bonig, Frank Kirchhoff, Jan Münch
Published 2015-05-01