The Role of Sulfhydryl Reactivity of Small Molecules for the Activation of the KEAP1/NRF2 Pathway and the Heat Shock Response

by Albena T. Dinkova-Kostova
Published 2012-01-01

KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease

by Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova
Published 2020-06-01

Editorial: Lignans: Insights Into Their Biosynthesis, Metabolic Engineering, Analytical Methods and Health Benefits

by Christophe F. Hano, Christophe F. Hano, Albena T. Dinkova-Kostova, Albena T. Dinkova-Kostova, Albena T. Dinkova-Kostova, Laurence B. Davin, John R. Cort, John R. Cort, Norman G. Lewis
Published 2021-01-01

NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis

by Holly Robertson, Albena T. Dinkova-Kostova, John D. Hayes
Published 2020-12-01

Broccoli or Sulforaphane: Is It the Source or Dose That Matters?

by Yoko Yagishita, Jed W. Fahey, Albena T. Dinkova-Kostova, Thomas W. Kensler
Published 2019-10-01

NRF2 as an Emerging Therapeutic Target

by Ian M. Copple, Albena T. Dinkova-Kostova, Thomas W. Kensler, Karen T. Liby, W. Christian Wigley
Published 2017-01-01

Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy—Mitochondria, Calcium Dynamics and Reactive Oxygen Species

by Stjepana Kovac, Albena T. Dinkova Kostova, Alexander M. Herrmann, Nico Melzer, Sven G. Meuth, Ali Gorji
Published 2017-09-01

The Cell-Permeable Derivative of the Immunoregulatory Metabolite Itaconate, 4-Octyl Itaconate, Is Anti-Fibrotic in Systemic Sclerosis

by John Henderson, Sharadha Dayalan Naidu, Albena T. Dinkova-Kostova, Stefan Przyborski, Richard Stratton, Steven O′Reilly
Published 2021-08-01

Studies on the mechanism of anti-inflammatory action of swietenine, a tetranortriterpenoid isolated from Swietenia macrophylla seeds

by Kit-Kay Mak, Zhang Shiming, Madhu Katyayani Balijepalli, Albena T. Dinkova-Kostova, Ola Epemolu, Zulkefeli Mohd, Mallikarjuna Rao Pichika
Published 2021-02-01

Clinically relevant aberrant Filip1l DNA methylation detected in a murine model of cutaneous squamous cell carcinoma

by Kevin Roth, Louis Coussement, Elena V. Knatko, Maureen Higgins, Sandra Steyaert, Charlotte M. Proby, Tim de Meyer, Albena T. Dinkova-Kostova
Published 2021-05-01

Nrf2 activation does not affect adenoma development in a mouse model of colorectal cancer

by Elena V. Knatko, Cecilia Castro, Maureen Higgins, Ying Zhang, Tadashi Honda, Colin J. Henderson, C. Roland Wolf, Julian L. Griffin, Albena T. Dinkova-Kostova
Published 2021-09-01

Investigation into the use of histone deacetylase inhibitor MS-275 as a topical agent for the prevention and treatment of cutaneous squamous cell carcinoma in an SKH-1 hairless mou...

by Jay H Kalin, Abdulkerim Eroglu, Hua Liu, W David Holtzclaw, Irene Leigh, Charlotte M Proby, Jed W Fahey, Philip A Cole, Albena T Dinkova-Kostova
Published 2019-01-01

Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration

by Kira M. Holmström, Liam Baird, Ying Zhang, Iain Hargreaves, Annapurna Chalasani, John M. Land, Lee Stanyer, Masayuki Yamamoto, Albena T. Dinkova-Kostova, Andrey Y. Abramov
Published 2013-06-01

Isomeric O-methyl cannabidiolquinones with dual BACH1/NRF2 activity

by Laura Casares, Juan Diego Unciti-Broceta, Maria Eugenia Prados, Diego Caprioglio, Daiana Mattoteia, Maureen Higgins, Giovanni Apendino, Albena T. Dinkova-Kostova, Eduardo Muñoz, Laureano de la Vega
Published 2020-10-01

Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism

by Yuta Horie, Takafumi Suzuki, Jin Inoue, Tatsuro Iso, Geoffrey Wells, Terry W. Moore, Tsunehiro Mizushima, Albena T. Dinkova-Kostova, Takuma Kasai, Takashi Kamei, Seizo Koshiba, Masayuki Yamamoto
Published 2021-05-01

Pathogenic p62/SQSTM1 mutations impair energy metabolism through limitation of mitochondrial substrates

by Fernando Bartolome, Noemi Esteras, Angeles Martin-Requero, Claire Boutoleau-Bretonniere, Martine Vercelletto, Audrey Gabelle, Isabelle Le Ber, Tadashi Honda, Albena T. Dinkova-Kostova, John Hardy, Eva Carro, Andrey Y. Abramov
Published 2017-05-01

Downregulation of Keap1 Confers Features of a Fasted Metabolic State

by Elena V. Knatko, Michael H. Tatham, Ying Zhang, Cecilia Castro, Maureen Higgins, Sharadha Dayalan Naidu, Chiara Leonardi, Laureano de la Vega, Tadashi Honda, Julian L. Griffin, Ronald T. Hay, Albena T. Dinkova-Kostova
Published 2020-10-01

High NRF2 Levels Correlate with Poor Prognosis in Colorectal Cancer Patients and with Sensitivity to the Kinase Inhibitor AT9283 In Vitro

by Laura Torrente, Gunjit Maan, Asma Oumkaltoum Rezig, Jean Quinn, Angus Jackson, Andrea Grilli, Laura Casares, Ying Zhang, Evgeny Kulesskiy, Jani Saarela, Silvio Bicciato, Joanne Edwards, Albena T. Dinkova-Kostova, Laureano de la Vega
Published 2020-09-01

Experimental Nonalcoholic Steatohepatitis and Liver Fibrosis Are Ameliorated by Pharmacologic Activation of Nrf2 (NF-E2 p45-Related Factor 2)

by Ritu S. Sharma, David J. Harrison, Dorothy Kisielewski, Diane M. Cassidy, Alison D. McNeilly, Jennifer R. Gallagher, Shaun V. Walsh, Tadashi Honda, Rory J. McCrimmon, Albena T. Dinkova-Kostova, Michael L.J. Ashford, John F. Dillon, John D. Hayes
Published 2018-01-01

A Defective Pentose Phosphate Pathway Reduces Inflammatory Macrophage Responses during Hypercholesterolemia

by Jeroen Baardman, Sanne G.S. Verberk, Koen H.M. Prange, Michel van Weeghel, Saskia van der Velden, Dylan G. Ryan, Rob C.I. Wüst, Annette E. Neele, Dave Speijer, Simone W. Denis, Maarten E. Witte, Riekelt H. Houtkooper, Luke A. O’neill, Elena V. Knatko, Albena T. Dinkova-Kostova, Esther Lutgens, Menno P.J. de Winther, Jan Van den Bossche
Published 2018-11-01