Paralog buffering contributes to the variable essentiality of genes in cancer cell lines.

by Barbara De Kegel, Colm J Ryan
Published 2019-10-01

Integrative analysis of large-scale loss-of-function screens identifies robust cancer-associated genetic interactions

by Christopher J Lord, Niall Quinn, Colm J Ryan
Published 2020-05-01

The yeast SR-like protein Npl3 links chromatin modification to mRNA processing.

by Erica A Moehle, Colm J Ryan, Nevan J Krogan, Tracy L Kress, Christine Guthrie
Published 2012-01-01

Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells.

by Andrey A Parkhitko, Arashdeep Singh, Sharon Hsieh, Yanhui Hu, Richard Binari, Christopher J Lord, Sridhar Hannenhalli, Colm J Ryan, Norbert Perrimon
Published 2021-02-01

Genetic interaction mapping reveals a role for the SWI/SNF nucleosome remodeler in spliceosome activation in fission yeast.

by Kristin L Patrick, Colm J Ryan, Jiewei Xu, Jesse J Lipp, Kelly E Nissen, Assen Roguev, Michael Shales, Nevan J Krogan, Christine Guthrie
Published 2015-03-01

Chemical Genetics of Rapamycin-Insensitive TORC2 in S. cerevisiae

by Joseph I. Kliegman, Dorothea Fiedler, Colm J. Ryan, Yi-Fan Xu, Xiao-yang Su, David Thomas, Max C. Caccese, Ada Cheng, Michael Shales, Joshua D. Rabinowitz, Nevan J. Krogan, Kevan M. Shokat
Published 2013-12-01

Accurate prediction of kinase-substrate networks using knowledge graphs.

by Vít Nováček, Gavin McGauran, David Matallanas, Adrián Vallejo Blanco, Piero Conca, Emir Muñoz, Luca Costabello, Kamalesh Kanakaraj, Zeeshan Nawaz, Brian Walsh, Sameh K Mohamed, Pierre-Yves Vandenbussche, Colm J Ryan, Walter Kolch, Dirk Fey
Published 2020-12-01

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

by Chris T. Williamson, Rowan Miller, Helen N. Pemberton, Samuel E. Jones, James Campbell, Asha Konde, Nicholas Badham, Rumana Rafiq, Rachel Brough, Aditi Gulati, Colm J. Ryan, Jeff Francis, Peter B. Vermulen, Andrew R. Reynolds, Philip M. Reaper, John R. Pollard, Alan Ashworth, Christopher J. Lord
Published 2016-12-01

Identification of a BET Family Bromodomain/Casein Kinase II/TAF-Containing Complex as a Regulator of Mitotic Condensin Function

by Hyun-Soo Kim, Rituparna Mukhopadhyay, Scott B. Rothbart, Andrea C. Silva, Vincent Vanoosthuyse, Ernest Radovani, Thomas Kislinger, Assen Roguev, Colm J. Ryan, Jiewei Xu, Harlizawati Jahari, Kevin G. Hardwick, Jack F. Greenblatt, Nevan J. Krogan, Jeffrey S. Fillingham, Brian D. Strahl, Eric E. Bouhassira, Winfried Edelmann, Michael-Christopher Keogh
Published 2014-03-01

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

by James Campbell, Colm J. Ryan, Rachel Brough, Ilirjana Bajrami, Helen N. Pemberton, Irene Y. Chong, Sara Costa-Cabral, Jessica Frankum, Aditi Gulati, Harriet Holme, Rowan Miller, Sophie Postel-Vinay, Rumana Rafiq, Wenbin Wei, Chris T. Williamson, David A. Quigley, Joe Tym, Bissan Al-Lazikani, Timothy Fenton, Rachael Natrajan, Sandra J. Strauss, Alan Ashworth, Christopher J. Lord
Published 2016-03-01

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D

by Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch
Published 2020-01-01