Targeting heat shock protein 90 for the treatment of malignant pheochromocytoma.

by Alessio Giubellino, Carole Sourbier, Min-Jung Lee, Brad Scroggins, Petra Bullova, Michael Landau, Weiwen Ying, Len Neckers, Jane B Trepel, Karel Pacak
Published 2013-01-01

Proteomic analysis of proteome and histone post-translational modifications in heat shock protein 90 inhibition-mediated bladder cancer therapeutics

by Qingdi Quentin Li, Jian-Jiang Hao, Zheng Zhang, L. Spencer Krane, Kai H. Hammerich, Thomas Sanford, Jane B. Trepel, Len Neckers, Piyush K. Agarwal
Published 2017-03-01

Client Proteins and Small Molecule Inhibitors Display Distinct Binding Preferences for Constitutive and Stress-Induced HSP90 Isoforms and Their Conformationally Restricted Mutants.

by Thomas L Prince, Toshiki Kijima, Manabu Tatokoro, Sunmin Lee, Shinji Tsutsumi, Kendrick Yim, Candy Rivas, Sylvia Alarcon, Harvey Schwartz, Kofi Khamit-Kush, Bradley T Scroggins, Kristin Beebe, Jane B Trepel, Len Neckers
Published 2015-01-01

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation

by Toshiki Kijima, Thomas L. Prince, Megan L. Tigue, Kendrick H. Yim, Harvey Schwartz, Kristin Beebe, Sunmin Lee, Marek A. Budzynski, Heinric Williams, Jane B. Trepel, Lea Sistonen, Stuart Calderwood, Len Neckers
Published 2018-05-01

Hsp90 middle domain phosphorylation initiates a complex conformational program to recruit the ATPase-stimulating cochaperone Aha1

by Wanping Xu, Kristin Beebe, Juan D. Chavez, Marta Boysen, YinYing Lu, Abbey D. Zuehlke, Dimitra Keramisanou, Jane B. Trepel, Christosomos Prodromou, Matthias P. Mayer, James E. Bruce, Ioannis Gelis, Len Neckers
Published 2019-06-01

An Hsp90 co-chaperone protein in yeast is functionally replaced by site-specific posttranslational modification in humans

by Abbey D. Zuehlke, Michael Reidy, Coney Lin, Paul LaPointe, Sarah Alsomairy, D. Joshua Lee, Genesis M. Rivera-Marquez, Kristin Beebe, Thomas Prince, Sunmin Lee, Jane B. Trepel, Wanping Xu, Jill Johnson, Daniel Masison, Len Neckers
Published 2017-05-01

A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient After Priming with RRx-001

by Bryan Oronsky, Scott Caroen, Karen Zeman, Mary Quinn, Christina Brzezniak, Jan Scicinski, Pedro Cabrales, Tony R. Reid, Jane B. Trepel, Nacer D. Abrouk, Christopher Larson, Arnold Oronsky, Harry E. Lybeck, Regina M. Day, Corey A. Carter
Published 2016-11-01

A Partial Response to Reintroduced Chemotherapy in a Resistant Small Cell Lung Cancer Patient after Priming with RRx-001

by Bryan Oronsky, Scott Caroen, Karen Zeman, Mary Quinn, Christina Brzezniak, Jan Scicinski, Pedro Cabrales, Tony R. Reid, Jane B. Trepel, Nacer D. Abrouk, Christopher Larson, Arnold Oronsky, Harry E. Lybeck, Regina M. Day, Corey A. Carter
Published 2016-01-01

Metabolomic and BH3 profiling of esophageal cancers: novel assessment methods for precision therapy

by R. Taylor Ripley, Deborah R. Surman, Laurence P. Diggs, Jane B. Trepel, Min-Jung Lee, Jeremy Ryan, Jeremy L. Davis, Seth M. Steinberg, Jonathan M. Hernandez, Choung Hoang, Cara M. Kenney, Colleen D. Bond, Tricia F. Kunst, Anthony Letai, David S. Schrump
Published 2018-06-01

A phase I study of the PD-L1 inhibitor, durvalumab, in combination with a PARP inhibitor, olaparib, and a VEGFR1–3 inhibitor, cediranib, in recurrent women’s cancers with biomarker...

by Alexandra S. Zimmer, Erin Nichols, Ashley Cimino-Mathews, Cody Peer, Liang Cao, Min-Jung Lee, Elise C. Kohn, Christina M. Annunziata, Stanley Lipkowitz, Jane B. Trepel, Rajni Sharma, Lekha Mikkilineni, Margaret Gatti-Mays, William D. Figg, Nicole D. Houston, Jung-Min Lee
Published 2019-07-01

Notch signaling and efficacy of PD-1/PD-L1 blockade in relapsed small cell lung cancer

by Nitin Roper, Moises J. Velez, Alberto Chiappori, Yoo Sun Kim, Jun S. Wei, Sivasish Sindiri, Nobuyuki Takahashi, Deborah Mulford, Suresh Kumar, Kris Ylaya, Christopher Trindade, Irena Manukyan, Anna-Leigh Brown, Jane B. Trepel, Jung-Min Lee, Stephen Hewitt, Javed Khan, Anish Thomas
Published 2021-06-01

CECs and IL-8 have prognostic and predictive utility in patients with recurrent platinum-sensitive ovarian cancer: biomarker correlates from the randomized phase 2 trial of olapari...

by Jung-Min eLee, Jane B. Trepel, Peter eChoyke, Liang eCao, Tristan M Sissung, Nicole eHouston, Minshu eYu, William D Figg, Ismail eTurkbey, Seth M. Steinberg, Min-Jung eLee, Percy eIvy, Joyce eLiu, Ursula eMatulonis, Elise eKohn
Published 2015-06-01

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors

by Mark R. Woodford, Andrew W. Truman, Diana M. Dunn, Sandra M. Jensen, Richard Cotran, Renee Bullard, Mourad Abouelleil, Kristin Beebe, Donald Wolfgeher, Sara Wierzbicki, Dawn E. Post, Tiffany Caza, Shinji Tsutsumi, Barry Panaretou, Stephen J. Kron, Jane B. Trepel, Steve Landas, Chrisostomos Prodromou, Oleg Shapiro, William G. Stetler-Stevenson, Dimitra Bourboulia, Len Neckers, Gennady Bratslavsky, Mehdi Mollapour
Published 2016-02-01

Activity of durvalumab plus olaparib in metastatic castration-resistant prostate cancer in men with and without DNA damage repair mutations

by Fatima Karzai, David VanderWeele, Ravi A. Madan, Helen Owens, Lisa M. Cordes, Amy Hankin, Anna Couvillon, Erin Nichols, Marijo Bilusic, Michael L. Beshiri, Kathleen Kelly, Venkatesh Krishnasamy, Sunmin Lee, Min-Jung Lee, Akira Yuno, Jane B. Trepel, Maria J. Merino, Ryan Dittamore, Jennifer Marté, Renee N. Donahue, Jeffrey Schlom, Keith J. Killian, Paul S. Meltzer, Seth M. Steinberg, James L. Gulley, Jung-Min Lee, William L. Dahut
Published 2018-12-01

c-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells

by Diana M. Dunn, Mark R. Woodford, Andrew W. Truman, Sandra M. Jensen, Jacqualyn Schulman, Tiffany Caza, Taylor C. Remillard, David Loiselle, Donald Wolfgeher, Brian S.J. Blagg, Lucas Franco, Timothy A. Haystead, Soumya Daturpalli, Matthias P. Mayer, Jane B. Trepel, Rhodri M.L. Morgan, Chrisostomos Prodromou, Stephen J. Kron, Barry Panaretou, William G. Stetler-Stevenson, Steve K. Landas, Len Neckers, Gennady Bratslavsky, Dimitra Bourboulia, Mehdi Mollapour
Published 2015-08-01

High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer

by Aizea Morales-Kastresana, Thomas A. Musich, Joshua A. Welsh, William Telford, Thorsten Demberg, James C. S. Wood, Marty Bigos, Carley D. Ross, Aliaksander Kachynski, Alan Dean, Edward J. Felton, Jonathan Van Dyke, John Tigges, Vasilis Toxavidis, David R. Parks, W. Roy Overton, Aparna H. Kesarwala, Gordon J. Freeman, Ariel Rosner, Stephen P. Perfetto, Lise Pasquet, Masaki Terabe, Katherine McKinnon, Veena Kapoor, Jane B. Trepel, Anu Puri, Hisataka Kobayashi, Bryant Yung, Xiaoyuan Chen, Peter Guion, Peter Choyke, Susan J. Knox, Ionita Ghiran, Marjorie Robert-Guroff, Jay A. Berzofsky, Jennifer C. Jones
Published 2019-12-01

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

by Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers
Published 2020-02-01