Room-Temperature, Copper-Free Sonogashira Reactions Facilitated by Air-Stable, Monoligated Precatalyst [DTBNpP] Pd(crotyl)Cl

by Katherine Pohida, David J. Maloney, Bryan T. Mott, Ganesha Rai
Published 2018-10-01

High-throughput 1,536-well fluorescence polarization assays for α(1)-acid glycoprotein and human serum albumin binding.

by Adam Yasgar, Silviya D Furdas, David J Maloney, Ajit Jadhav, Manfred Jung, Anton Simeonov
Published 2012-01-01

Diverse small molecule inhibitors of human apurinic/apyrimidinic endonuclease APE1 identified from a screen of a large public collection.

by Dorjbal Dorjsuren, Daemyung Kim, Vaddadi N Vyjayanti, David J Maloney, Ajit Jadhav, David M Wilson, Anton Simeonov
Published 2012-01-01

A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ.

by Kinrin Yamanaka, Dorjbal Dorjsuren, Robert L Eoff, Martin Egli, David J Maloney, Ajit Jadhav, Anton Simeonov, R Stephen Lloyd
Published 2012-01-01

A high throughput screen identifies potent and selective inhibitors to human epithelial 15-lipoxygenase-2.

by J Brian Jameson, Auric Kantz, Lena Schultz, Chakrapani Kalyanaraman, Matthew P Jacobson, David J Maloney, Ajit Jadhav, Anton Simeonov, Theodore R Holman
Published 2014-01-01

A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

by Adam Yasgar, Steven A Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J Maloney, Anton Simeonov, Natalia J Martinez
Published 2017-01-01

Correction: A High-Content Assay Enables the Automated Screening and Identification of Small Molecules with Specific ALDH1A1-Inhibitory Activity.

by Adam Yasgar, Steven A Titus, Yuhong Wang, Carina Danchik, Shyh-Ming Yang, Vasilis Vasiliou, Ajit Jadhav, David J Maloney, Anton Simeonov, Natalia J Martinez
Published 2018-01-01

A high-throughput screen to identify novel small molecule inhibitors of the Werner Syndrome Helicase-Nuclease (WRN).

by Joshua A Sommers, Tomasz Kulikowicz, Deborah L Croteau, Thomas Dexheimer, Dorjbal Dorjsuren, Ajit Jadhav, David J Maloney, Anton Simeonov, Vilhelm A Bohr, Robert M Brosh
Published 2019-01-01

High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships.

by Frank H Niesen, Lena Schultz, Ajit Jadhav, Chitra Bhatia, Kunde Guo, David J Maloney, Ewa S Pilka, Minghua Wang, Udo Oppermann, Tom D Heightman, Anton Simeonov
Published 2010-11-01

Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol

by Kelly A Manthei, Shyh-Ming Yang, Bolormaa Baljinnyam, Louise Chang, Alisa Glukhova, Wenmin Yuan, Lita A Freeman, David J Maloney, Anna Schwendeman, Alan T Remaley, Ajit Jadhav, John JG Tesmer
Published 2018-11-01

Discovery of a novel dual fungal CYP51/human 5-lipoxygenase inhibitor: implications for anti-fungal therapy.

by Eric K Hoobler, Ganesha Rai, Andrew G S Warrilow, Steven C Perry, Christopher J Smyrniotis, Ajit Jadhav, Anton Simeonov, Josie E Parker, Diane E Kelly, David J Maloney, S L Kelly, Theodore R Holman
Published 2013-01-01

Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.

by Oliver N F King, Xuan Shirley Li, Masaaki Sakurai, Akane Kawamura, Nathan R Rose, Stanley S Ng, Amy M Quinn, Ganesha Rai, Bryan T Mott, Paul Beswick, Robert J Klose, Udo Oppermann, Ajit Jadhav, Tom D Heightman, David J Maloney, Christopher J Schofield, Anton Simeonov
Published 2010-11-01

Correction: A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Mode...

by Natalia J Martinez, Ganesha Rai, Adam Yasgar, Wendy A Lea, Hongmao Sun, Yuhong Wang, Diane K Luci, Shyh-Ming Yang, Kana Nishihara, Shunichi Takeda, Mohiuddin, Irina Earnshaw, Tetsuya Okada, Kazutoshi Mori, Kelli Wilson, Gregory J Riggins, Menghang Xia, Maurizio Grimaldi, Ajit Jadhav, David J Maloney, Anton Simeonov
Published 2016-01-01

A High-Throughput Screen Identifies 2,9-Diazaspiro[5.5]Undecanes as Inducers of the Endoplasmic Reticulum Stress Response with Cytotoxic Activity in 3D Glioma Cell Models.

by Natalia J Martinez, Ganesha Rai, Adam Yasgar, Wendy A Lea, Hongmao Sun, Yuhong Wang, Diane K Luci, Shyh-Ming Yang, Kana Nishihara, Shunichi Takeda, Mohiuddin Sagor, Irina Earnshaw, Tetsuya Okada, Kazutoshi Mori, Kelli Wilson, Gregory J Riggins, Menghang Xia, Maurizio Grimaldi, Ajit Jadhav, David J Maloney, Anton Simeonov
Published 2016-01-01

KDM5 histone demethylases repress immune response via suppression of STING.

by Lizhen Wu, Jian Cao, Wesley L Cai, Sabine M Lang, John R Horton, Daniel J Jansen, Zongzhi Z Liu, Jocelyn F Chen, Meiling Zhang, Bryan T Mott, Katherine Pohida, Ganesha Rai, Stephen C Kales, Mark J Henderson, Xin Hu, Ajit Jadhav, David J Maloney, Anton Simeonov, Shu Zhu, Akiko Iwasaki, Matthew D Hall, Xiaodong Cheng, Gerald S Shadel, Qin Yan
Published 2018-08-01

Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites

by Dorjbal Dorjsuren, Richard T. Eastman, Kathryn J. Wicht, Daniel Jansen, Daniel C. Talley, Benjamin A. Sigmon, Alexey V. Zakharov, Norma Roncal, Andrew T. Girvin, Yevgeniya Antonova-Koch, Paul M. Will, Pranav Shah, Hongmao Sun, Carleen Klumpp-Thomas, Sachel Mok, Tomas Yeo, Stephan Meister, Juan Jose Marugan, Leila S. Ross, Xin Xu, David J. Maloney, Ajit Jadhav, Bryan T. Mott, Richard J. Sciotti, Elizabeth A. Winzeler, Norman C. Waters, Robert F. Campbell, Wenwei Huang, Anton Simeonov, David A. Fidock
Published 2021-01-01

Dynamic Imaging of LDH Inhibition in Tumors Reveals Rapid In Vivo Metabolic Rewiring and Vulnerability to Combination Therapy

by Nobu Oshima, Ryo Ishida, Shun Kishimoto, Kristin Beebe, Jeffrey R. Brender, Kazutoshi Yamamoto, Daniel Urban, Ganesha Rai, Michelle S. Johnson, Gloria Benavides, Giuseppe L. Squadrito, Dan Crooks, Joseph Jackson, Abhinav Joshi, Bryan T. Mott, Jonathan H. Shrimp, Michael A. Moses, Min-Jung Lee, Akira Yuno, Tobie D. Lee, Xin Hu, Tamara Anderson, Donna Kusewitt, Helen H. Hathaway, Ajit Jadhav, Didier Picard, Jane B. Trepel, James B. Mitchell, Gordon M. Stott, William Moore, Anton Simeonov, Larry A. Sklar, Jeffrey P. Norenberg, W. Marston Linehan, David J. Maloney, Chi V. Dang, Alex G. Waterson, Matthew Hall, Victor M. Darley-Usmar, Murali C. Krishna, Leonard M. Neckers
Published 2020-02-01