Down Syndrome and COVID-19: A Perfect Storm?

by Joaquin M. Espinosa
Published 2020-05-01

Tumor Suppression by p53: Is Apoptosis Important or Not?

by Hestia Mellert, Joaquín M. Espinosa
Published 2013-05-01

A signature for success

by Joaquín M Espinosa, Kelly D Sullivan
Published 2015-06-01

Multi-omics analysis reveals contextual tumor suppressive and oncogenic gene modules within the acute hypoxic response

by Zdenek Andrysik, Heather Bender, Matthew D. Galbraith, Joaquin M. Espinosa
Published 2021-03-01

A Genetic Screen Identifies TCF3/E2A and TRIAP1 as Pathway-Specific Regulators of the Cellular Response to p53 Activation

by Zdenek Andrysik, Jihye Kim, Aik Choon Tan, Joaquín M. Espinosa
Published 2013-05-01

NPM and BRG1 Mediate Transcriptional Resistance to Retinoic Acid in Acute Promyelocytic Leukemia

by Jessica N. Nichol, Matthew D. Galbraith, Claudia L. Kleinman, Joaquín M. Espinosa, Wilson H. Miller Jr.
Published 2016-03-01

Autophagy Controls the Kinetics and Extent of Mitochondrial Apoptosis by Regulating PUMA Levels

by Jacqueline Thorburn, Zdenek Andrysik, Leah Staskiewicz, Jacob Gump, Paola Maycotte, Andrew Oberst, Douglas R. Green, Joaquín M. Espinosa, Andrew Thorburn
Published 2014-04-01

ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas

by Christopher G. Abraham, Michael P. Ludwig, Zdenek Andrysik, Ahwan Pandey, Molishree Joshi, Matthew D. Galbraith, Kelly D. Sullivan, Joaquin M. Espinosa
Published 2018-09-01

CDK8 Kinase Activity Promotes Glycolysis

by Matthew D. Galbraith, Zdenek Andrysik, Ahwan Pandey, Maria Hoh, Elizabeth A. Bonner, Amanda A. Hill, Kelly D. Sullivan, Joaquín M. Espinosa
Published 2017-11-01

The TIP60 Complex Is a Conserved Coactivator of HIF1A

by Joel I. Perez-Perri, Veronica L. Dengler, K. Audrey Audetat, Ahwan Pandey, Elizabeth A. Bonner, Marjeta Urh, Jacqui Mendez, Danette L. Daniels, Pablo Wappner, Matthew D. Galbraith, Joaquín M. Espinosa
Published 2016-06-01

Global analysis of p53-regulated transcription identifies its direct targets and unexpected regulatory mechanisms

by Mary Ann Allen, Zdenek Andrysik, Veronica L Dengler, Hestia S Mellert, Anna Guarnieri, Justin A Freeman, Kelly D Sullivan, Matthew D Galbraith, Xin Luo, W Lee Kraus, Robin D Dowell, Joaquin M Espinosa
Published 2014-05-01

Trisomy 21 consistently activates the interferon response

by Kelly D Sullivan, Hannah C Lewis, Amanda A Hill, Ahwan Pandey, Leisa P Jackson, Joseph M Cabral, Keith P Smith, L Alexander Liggett, Eliana B Gomez, Matthew D Galbraith, James DeGregori, Joaquín M Espinosa
Published 2016-07-01

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase

by Forest H. Andrews, Qiong Tong, Kelly D. Sullivan, Evan M. Cornett, Yi Zhang, Muzaffar Ali, JaeWoo Ahn, Ahway Pandey, Angela H. Guo, Brian D. Strahl, James C. Costello, Joaquin M. Espinosa, Scott B. Rothbart, Tatiana G. Kutateladze
Published 2016-09-01

JAK1 Inhibition Blocks Lethal Immune Hypersensitivity in a Mouse Model of Down Syndrome

by Kathryn D. Tuttle, Katherine A. Waugh, Paula Araya, Ross Minter, David J. Orlicky, Michael Ludwig, Zdenek Andrysik, Matthew A. Burchill, Beth A.J. Tamburini, Colin Sempeck, Keith Smith, Ross Granrath, Dayna Tracy, Jessica Baxter, Joaquin M. Espinosa, Kelly D. Sullivan
Published 2020-11-01

Multi-Omic Approaches Identify Metabolic and Autophagy Regulators Important in Ovarian Cancer Dissemination

by Lindsay J. Wheeler, Zachary L. Watson, Lubna Qamar, Tomomi M. Yamamoto, Brandon T. Sawyer, Kelly D. Sullivan, Santosh Khanal, Molishree Joshi, Veronique Ferchaud-Roucher, Harry Smith, Lauren A. Vanderlinden, Sky W. Brubaker, Cecilia M. Caino, Hyunmin Kim, Joaquin M. Espinosa, Jennifer K. Richer, Benjamin G. Bitler
Published 2019-09-01

Seroconversion stages COVID19 into distinct pathophysiological states

by Matthew D Galbraith, Kohl T Kinning, Kelly D Sullivan, Ryan Baxter, Paula Araya, Kimberly R Jordan, Seth Russell, Keith P Smith, Ross E Granrath, Jessica R Shaw, Monika Dzieciatkowska, Tusharkanti Ghosh, Andrew A Monte, Angelo D'Alessandro, Kirk C Hansen, Tellen D Benett, Elena WY Hsieh, Joaquín M Espinosa
Published 2021-03-01

Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors

by Rani K. Powers, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona-Iragui, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquin M. Espinosa
Published 2019-10-01

Mass Cytometry Reveals Global Immune Remodeling with Multi-lineage Hypersensitivity to Type I Interferon in Down Syndrome

by Katherine A. Waugh, Paula Araya, Ahwan Pandey, Kimberly R. Jordan, Keith P. Smith, Ross E. Granrath, Santosh Khanal, Eric T. Butcher, Belinda Enriquez Estrada, Angela L. Rachubinski, Jennifer A. McWilliams, Ross Minter, Tiana Dimasi, Kelley L. Colvin, Dmitry Baturin, Andrew T. Pham, Matthew D. Galbraith, Kyle W. Bartsch, Michael E. Yeager, Christopher C. Porter, Kelly D. Sullivan, Elena W. Hsieh, Joaquin M. Espinosa
Published 2019-11-01