Treating cancer with phosphatidylinositol-3-kinase inhibitors: increasing efficacy and overcoming resistance

by Marcia N. Paddock, Seth J. Field, Lewis C. Cantley
Published 2019-04-01

Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification

by Inah Hwang, Hiroki Uchida, Ziwei Dai, Fei Li, Teresa Sanchez, Jason W. Locasale, Lewis C. Cantley, Hongwu Zheng, Jihye Paik
Published 2021-01-01

Development of a CDK10/CycM in vitro Kinase Screening Assay and Identification of First Small-Molecule Inhibitors

by Thomas Robert, Thomas Robert, Jared L. Johnson, Roxane Guichaoua, Tomer M. Yaron, Stéphane Bach, Stéphane Bach, Lewis C. Cantley, Pierre Colas
Published 2020-02-01

Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε.

by Jessica E Hutti, Melissa A Porter, Adam W Cheely, Lewis C Cantley, Xiaodong Wang, Dmitri Kireev, Albert S Baldwin, William P Janzen
Published 2012-01-01

Rac-Mediated Macropinocytosis of Extracellular Protein Promotes Glucose Independence in Non-Small Cell Lung Cancer

by Cindy Hodakoski, Benjamin D. Hopkins, Guoan Zhang, Taojunfeng Su, Zhe Cheng, Roxanne Morris, Kyu Y. Rhee, Marcus D. Goncalves, Lewis C. Cantley
Published 2019-01-01

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

by Orion D Weiner, Maike C Rentel, Alex Ott, Glenn E Brown, Mark Jedrychowski, Michael B Yaffe, Steven P Gygi, Lewis C Cantley, Henry R Bourne, Marc W Kirschner
Published 2006-02-01

Results of an abbreviated phase II study of AKT inhibitor MK-2206 in the treatment of recurrent platinum-resistant high grade serous ovarian, fallopian tube, or primary peritoneal...

by Elizabeth K. Lee, Zhenying Tan-Wasielewski, Carol Aghajanian, Robert L. Coleman, Jennifer Curtis, Michelle S. Hirsch, Ursula A. Matulonis, Lewis C. Cantley, Gordon B. Mills, L. Austin Doyle, Joyce F. Liu
Published 2020-05-01

Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin

by Althea N. Waldhart, Holly Dykstra, Anderson S. Peck, Elissa A. Boguslawski, Zachary B. Madaj, Jennifer Wen, Kelsey Veldkamp, Matthew Hollowell, Bin Zheng, Lewis C. Cantley, Timothy E. McGraw, Ning Wu
Published 2017-06-01

The chromatin remodeler RSF1 controls centromeric histone modifications to coordinate chromosome segregation

by Ho-Soo Lee, Zhonghui Lin, Sunyoung Chae, Young-Suk Yoo, Byung-Gyu Kim, Youngsoo Lee, Jared L. Johnson, You-Sun Kim, Lewis C. Cantley, Chang-Woo Lee, Hongtao Yu, Hyeseong Cho
Published 2018-09-01

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

by Helen I. Woodroof, Joe H. Pogson, Mike Begley, Lewis C. Cantley, Maria Deak, David G. Campbell, Daan M. F. van Aalten, Alexander J. Whitworth, Dario R. Alessi, Miratul M. K. Muqit
Published 2011-01-01

A homogeneous, high-throughput assay for phosphatidylinositol 5-phosphate 4-kinase with a novel, rapid substrate preparation.

by Mindy I Davis, Atsuo T Sasaki, Min Shen, Brooke M Emerling, Natasha Thorne, Sam Michael, Rajan Pragani, Matthew Boxer, Kazutaka Sumita, Koh Takeuchi, Douglas S Auld, Zhuyin Li, Lewis C Cantley, Anton Simeonov
Published 2013-01-01

Quantitative In Vivo Proteomics of Metformin Response in Liver Reveals AMPK-Dependent and -Independent Signaling Networks

by Benjamin D. Stein, Diego Calzolari, Kristina Hellberg, Ying S. Hu, Lin He, Chien-Min Hung, Erin Q. Toyama, Debbie S. Ross, Björn F. Lillemeier, Lewis C. Cantley, John R. Yates, III, Reuben J. Shaw
Published 2019-12-01

Somatic mutations of PIK3R1 promote gliomagenesis.

by Steven N Quayle, Jennifer Y Lee, Lydia W T Cheung, Li Ding, Ruprecht Wiedemeyer, Robert W Dewan, Emmet Huang-Hobbs, Li Zhuang, Richard K Wilson, Keith L Ligon, Gordon B Mills, Lewis C Cantley, Lynda Chin
Published 2012-01-01

GLUT5 (SLC2A5) enables fructose-mediated proliferation independent of ketohexokinase

by Roger J. Liang, Samuel Taylor, Navid Nahiyaan, Junho Song, Charles J. Murphy, Ezequiel Dantas, Shuyuan Cheng, Ting-Wei Hsu, Shakti Ramsamooj, Rahul Grover, Seo-Kyoung Hwang, Bryan Ngo, Lewis C. Cantley, Kyu Y. Rhee, Marcus D. Goncalves
Published 2021-03-01

Proteomic and Metabolomic Characterization of a Mammalian Cellular Transition from Quiescence to Proliferation

by Ho-Joon Lee, Mark P. Jedrychowski, Arunachalam Vinayagam, Ning Wu, Ng Shyh-Chang, Yanhui Hu, Chua Min-Wen, Jodene K. Moore, John M. Asara, Costas A. Lyssiotis, Norbert Perrimon, Steven P. Gygi, Lewis C. Cantley, Marc W. Kirschner
Published 2017-07-01

PIP4Ks Suppress Insulin Signaling through a Catalytic-Independent Mechanism

by Diana G. Wang, Marcia N. Paddock, Mark R. Lundquist, Janet Y. Sun, Oksana Mashadova, Solomon Amadiume, Timothy W. Bumpus, Cindy Hodakoski, Benjamin D. Hopkins, Matthew Fine, Amanda Hill, T. Jonathan Yang, Jeremy M. Baskin, Lukas E. Dow, Lewis C. Cantley
Published 2019-05-01

Proline rich 11 (PRR11) overexpression amplifies PI3K signaling and promotes antiestrogen resistance in breast cancer

by Kyung-min Lee, Angel L. Guerrero-Zotano, Alberto Servetto, Dhivya R. Sudhan, Chang-Ching Lin, Luigi Formisano, Valerie M. Jansen, Paula González-Ericsson, Melinda E. Sanders, Thomas P. Stricker, Ganesh Raj, Kevin M. Dean, Reto Fiolka, Lewis C. Cantley, Ariella B. Hanker, Carlos L. Arteaga
Published 2020-10-01

Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

by Malcolm A Leissring, Enrico Malito, Sabrine Hedouin, Lael Reinstatler, Tomoko Sahara, Samer O Abdul-Hay, Shakeel Choudhry, Ghulam M Maharvi, Abdul H Fauq, Malwina Huzarska, Philip S May, Sungwoon Choi, Todd P Logan, Benjamin E Turk, Lewis C Cantley, Marika Manolopoulou, Wei-Jen Tang, Ross L Stein, Gregory D Cuny, Dennis J Selkoe
Published 2010-05-01

Phase 2 study of buparlisib (BKM120), a pan-class I PI3K inhibitor, in patients with metastatic triple-negative breast cancer

by Ana C. Garrido-Castro, Cristina Saura, Romualdo Barroso-Sousa, Hao Guo, Eva Ciruelos, Begoña Bermejo, Joaquin Gavilá, Violeta Serra, Aleix Prat, Laia Paré, Pamela Céliz, Patricia Villagrasa, Yisheng Li, Jennifer Savoie, Zhan Xu, Carlos L. Arteaga, Ian E. Krop, David B. Solit, Gordon B. Mills, Lewis C. Cantley, Eric P. Winer, Nancy U. Lin, Jordi Rodon
Published 2020-11-01

Tissue of origin dictates GOT1 dependence and confers synthetic lethality to radiotherapy

by Barbara S. Nelson, Lin Lin, Daniel M. Kremer, Cristovão M. Sousa, Cecilia Cotta-Ramusino, Amy Myers, Johanna Ramos, Tina Gao, Ilya Kovalenko, Kari Wilder-Romans, Joseph Dresser, Mary Davis, Ho-Joon Lee, Zeribe C. Nwosu, Scott Campit, Oksana Mashadova, Brandon N. Nicolay, Zachary P. Tolstyka, Christopher J. Halbrook, Sriram Chandrasekaran, John M. Asara, Howard C. Crawford, Lewis C. Cantley, Alec C. Kimmelman, Daniel R. Wahl, Costas A. Lyssiotis
Published 2020-01-01