A Dynamic molecular basis for malfunction in disease mutants of p97/VCP

by Anne K Schuetz, Lewis E Kay
Published 2016-11-01

Is buffer a good proxy for a crowded cell-like environment? A comparative NMR study of calmodulin side-chain dynamics in buffer and E. coli lysate.

by Michael P Latham, Lewis E Kay
Published 2012-01-01

An economical method for production of (2)H, (13)CH3-threonine for solution NMR studies of large protein complexes: application to the 670 kDa proteasome.

by Algirdas Velyvis, Amy M Ruschak, Lewis E Kay
Published 2012-01-01

Promiscuous binding by Hsp70 results in conformational heterogeneity and fuzzy chaperone-substrate ensembles

by Rina Rosenzweig, Ashok Sekhar, Jayashree Nagesh, Lewis E Kay
Published 2017-07-01

Studying Protein-Excited States by Nmr

by Tony Mittermaier, Frans Mulder, Rick Dahlquist, Lewis E. Kay
Published 2002-01-01

Atomic resolution mechanism of ligand binding to a solvent inaccessible cavity in T4 lysozyme.

by Jagannath Mondal, Navjeet Ahalawat, Subhendu Pandit, Lewis E Kay, Pramodh Vallurupalli
Published 2018-05-01

Structure of a AAA+ unfoldase in the process of unfolding substrate

by Zev A Ripstein, Rui Huang, Rafal Augustyniak, Lewis E Kay, John L Rubinstein
Published 2017-04-01

Conserved conformational selection mechanism of Hsp70 chaperone-substrate interactions

by Ashok Sekhar, Algirdas Velyvis, Guy Zoltsman, Rina Rosenzweig, Guillaume Bouvignies, Lewis E Kay
Published 2018-02-01

A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery

by Zev A Ripstein, Siavash Vahidi, Walid A Houry, John L Rubinstein, Lewis E Kay
Published 2020-01-01

Thermal fluctuations of immature SOD1 lead to separate folding and misfolding pathways

by Ashok Sekhar, Jessica AO Rumfeldt, Helen R Broom, Colleen M Doyle, Guillaume Bouvignies, Elizabeth M Meiering, Lewis E Kay
Published 2015-06-01

Global multi-method analysis of interaction parameters for reversibly self-associating macromolecules at high concentrations

by Arun Parupudi, Sumit K. Chaturvedi, Regina Adão, Robert W. Harkness, Sonia Dragulin-Otto, Lewis E. Kay, Reza Esfandiary, Huaying Zhao, Peter Schuck
Published 2021-03-01

Interplay of buried histidine protonation and protein stability in prion misfolding

by Anatoly Malevanets, P. Andrew Chong, D. Flemming Hansen, Paul Rizk, Yulong Sun, Hong Lin, Ranjith Muhandiram, Avi Chakrabartty, Lewis E. Kay, Julie D. Forman-Kay, Shoshana J. Wodak
Published 2017-04-01

The ZIP5 ectodomain co-localizes with PrP and may acquire a PrP-like fold that assembles into a dimer.

by Cosmin L Pocanschi, Sepehr Ehsani, Mohadeseh Mehrabian, Holger Wille, William Reginold, William S Trimble, Hansen Wang, Adelinda Yee, Cheryl H Arrowsmith, Zoltán Bozóky, Lewis E Kay, Julie D Forman-Kay, James M Rini, Gerold Schmitt-Ulms
Published 2013-01-01

The RNF168 paralog RNF169 defines a new class of ubiquitylated histone reader involved in the response to DNA damage

by Julianne Kitevski-LeBlanc, Amélie Fradet-Turcotte, Predrag Kukic, Marcus D Wilson, Guillem Portella, Tairan Yuwen, Stephanie Panier, Shili Duan, Marella D Canny, Hugo van Ingen, Cheryl H Arrowsmith, John L Rubinstein, Michele Vendruscolo, Daniel Durocher, Lewis E Kay
Published 2017-04-01