Framework for capacity based sustainable design & development: towards resilient communities

by Michaël Willem Maria Smits
Published 2019-12-01

Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer’s Disease

by Paola Vitale, Ana Rita Salgueiro-Pereira, Carmen Alina Lupascu, Michael Willem, Rosanna Migliore, Michele Migliore, Hélène Marie
Published 2021-06-01

Specific Inhibition of β-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

by Saoussen Ben Halima, Sabyashachi Mishra, K. Muruga Poopathi Raja, Michael Willem, Antonio Baici, Kai Simons, Oliver Brüstle, Philipp Koch, Christian Haass, Amedeo Caflisch, Lawrence Rajendran
Published 2016-03-01

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

by Paula A Pousinha, Xavier Mouska, Elisabeth F Raymond, Carole Gwizdek, Gihen Dhib, Gwenola Poupon, Laure-Emmanuelle Zaragosi, Camilla Giudici, Ingrid Bethus, Emilie Pacary, Michael Willem, Hélène Marie
Published 2017-07-01

Aη-α and Aη-β peptides impair LTP ex vivo within the low nanomolar range and impact neuronal activity in vivo

by Maria Mensch, Jade Dunot, Sandy M. Yishan, Samuel S. Harris, Aline Blistein, Alban Avdiu, Paula A. Pousinha, Camilla Giudici, Marc Aurel Busche, Peter Jedlicka, Michael Willem, Hélène Marie
Published 2021-07-01

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

by Laura Sebastian Monasor, Stephan A Müller, Alessio Vittorio Colombo, Gaye Tanrioever, Jasmin König, Stefan Roth, Arthur Liesz, Anna Berghofer, Anke Piechotta, Matthias Prestel, Takashi Saito, Takaomi C Saido, Jochen Herms, Michael Willem, Christian Haass, Stefan F Lichtenthaler, Sabina Tahirovic
Published 2020-06-01

Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in AppNL-G-F mice

by Gloria Biechele, Karin Wind, Tanja Blume, Christian Sacher, Leonie Beyer, Florian Eckenweber, Nicolai Franzmeier, Michael Ewers, Benedikt Zott, Simon Lindner, Franz-Josef Gildehaus, Barbara von Ungern-Sternberg, Sabina Tahirovic, Michael Willem, Peter Bartenstein, Paul Cumming, Axel Rominger, Jochen Herms, Matthias Brendel
Published 2021-04-01

Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region

by Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti‐Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun‐Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haass
Published 2020-04-01