A Viral Polymerase Inhibitor Reduces Zika Virus Replication in the Reproductive Organs of Male Mice

by Sofie Jacobs, Leen Delang, Eric Verbeken, Johan Neyts, Suzanne J.F. Kaptein
Published 2019-04-01

Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals.

by Tine Tricot, Nicky Helsen, Suzanne J F Kaptein, Johan Neyts, Catherine M Verfaillie
Published 2018-01-01

The Viral Polymerase Inhibitor 7-Deaza-2'-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Mode...

by Joanna Zmurko, Rafael E Marques, Dominique Schols, Erik Verbeken, Suzanne J F Kaptein, Johan Neyts
Published 2016-05-01

Broad antiviral activity of carbohydrate-binding agents against the four serotypes of dengue virus in monocyte-derived dendritic cells.

by Marijke M F Alen, Tine De Burghgraeve, Suzanne J F Kaptein, Jan Balzarini, Johan Neyts, Dominique Schols
Published 2011-01-01

Comparing infectivity and virulence of emerging SARS-CoV-2 variants in Syrian hamsters

by Rana Abdelnabi, Robbert Boudewijns, Caroline S. Foo, Laura Seldeslachts, Lorena Sanchez-Felipe, Xin Zhang, Leen Delang, Piet Maes, Suzanne J.F. Kaptein, Birgit Weynand, Greetje Vande Velde, Johan Neyts, Kai Dallmeier
Published 2021-06-01

An analogue of the antibiotic teicoplanin prevents flavivirus entry in vitro.

by Tine De Burghgraeve, Suzanne J F Kaptein, Nilda V Ayala-Nunez, Juan A Mondotte, Boris Pastorino, Svetlana S Printsevskaya, Xavier de Lamballerie, Michael Jacobs, Maria Preobrazhenskaya, Andrea V Gamarnik, Jolanda M Smit, Johan Neyts
Published 2012-01-01

The combined treatment of Molnupiravir and Favipiravir results in a potentiation of antiviral efficacy in a SARS-CoV-2 hamster infection model

by Rana Abdelnabi, Caroline S. Foo, Suzanne J.F. Kaptein, Xin Zhang, Thuc Nguyen Dan Do, Lana Langendries, Laura Vangeel, Judith Breuer, Juanita Pang, Rachel Williams, Valentijn Vergote, Elisabeth Heylen, Pieter Leyssen, Kai Dallmeier, Lotte Coelmont, Arnab K. Chatterjee, Raf Mols, Patrick Augustijns, Steven De Jonghe, Dirk Jochmans, Birgit Weynand, Johan Neyts
Published 2021-10-01

Reverse engineering synthetic antiviral amyloids

by Emiel Michiels, Kenny Roose, Rodrigo Gallardo, Ladan Khodaparast, Laleh Khodaparast, Rob van der Kant, Maxime Siemons, Bert Houben, Meine Ramakers, Hannah Wilkinson, Patricia Guerreiro, Nikolaos Louros, Suzanne J. F. Kaptein, Lorena Itatí Ibañez, Anouk Smet, Pieter Baatsen, Shu Liu, Ina Vorberg, Guy Bormans, Johan Neyts, Xavier Saelens, Frederic Rousseau, Joost Schymkowitz
Published 2020-06-01

Recent African strains of Zika virus display higher transmissibility and fetal pathogenicity than Asian strains

by Fabien Aubry, Sofie Jacobs, Maïlis Darmuzey, Sebastian Lequime, Leen Delang, Albin Fontaine, Natapong Jupatanakul, Elliott F. Miot, Stéphanie Dabo, Caroline Manet, Xavier Montagutelli, Artem Baidaliuk, Fabiana Gámbaro, Etienne Simon-Lorière, Maxime Gilsoul, Claudia M. Romero-Vivas, Van-Mai Cao-Lormeau, Richard G. Jarman, Cheikh T. Diagne, Oumar Faye, Ousmane Faye, Amadou A. Sall, Johan Neyts, Laurent Nguyen, Suzanne J. F. Kaptein, Louis Lambrechts
Published 2021-02-01

Corrigendum to “itraconazole for COVID-19: Preclinical studies and a proof-of-concept randomized clinical trial Laurens”

by Laurens Liesenborghs, Isabel Spriet, Dirk Jochmans, Ann Belmans, Iwein Gyselinck, Laure-Anne Teuwen, Sebastiaan ter Horst, Erwin Dreesen, Tatjana Geukens, Matthias M. Engelen, Ewout Landeloos, Vincent Geldhof, Helga Ceunen, Barbara Debaveye, Bert Vandenberk, Lorenz Van der Linden, Sofie Jacobs, Lana Langendries, Robbert Boudewijns, Thuc Nguyen Dan Do, Winston Chiu, Xinyu Wang, Xin Zhang, Birgit Weynand, Thomas Vanassche, Timothy Devos, Geert Meyfroidt, Wim Janssens, Robin Vos, Pieter Vermeersch, Joost Wauters, Geert Verbeke, Paul De Munter, Suzanne J.F. Kaptein, Joana Rocha-Pereira, Leen Delang, Eric Van Wijngaerden, Johan Neyts, Peter Verhamme
Published 2021-07-01

STAT2 signaling restricts viral dissemination but drives severe pneumonia in SARS-CoV-2 infected hamsters

by Robbert Boudewijns, Hendrik Jan Thibaut, Suzanne J. F. Kaptein, Rong Li, Valentijn Vergote, Laura Seldeslachts, Johan Van Weyenbergh, Carolien De Keyzer, Lindsey Bervoets, Sapna Sharma, Laurens Liesenborghs, Ji Ma, Sander Jansen, Dominique Van Looveren, Thomas Vercruysse, Xinyu Wang, Dirk Jochmans, Erik Martens, Kenny Roose, Dorien De Vlieger, Bert Schepens, Tina Van Buyten, Sofie Jacobs, Yanan Liu, Joan Martí-Carreras, Bert Vanmechelen, Tony Wawina-Bokalanga, Leen Delang, Joana Rocha-Pereira, Lotte Coelmont, Winston Chiu, Pieter Leyssen, Elisabeth Heylen, Dominique Schols, Lanjiao Wang, Lila Close, Jelle Matthijnssens, Marc Van Ranst, Veerle Compernolle, Georg Schramm, Koen Van Laere, Xavier Saelens, Nico Callewaert, Ghislain Opdenakker, Piet Maes, Birgit Weynand, Christopher Cawthorne, Greetje Vande Velde, Zhongde Wang, Johan Neyts, Kai Dallmeier
Published 2020-11-01

Itraconazole for COVID-19: preclinical studies and a proof-of-concept randomized clinical trial

by Laurens Liesenborghs, M.D., Isabel Spriet, Pharm.D., Dirk Jochmans, Ph.D., Ann Belmans, Ph.D., Iwein Gyselinck, M.D., Laure-Anne Teuwen, M.D., Sebastiaan ter Horst, Msc., Erwin Dreesen, Ph.D., Tatjana Geukens, M.D., Matthias M. Engelen, M.D., Ewout Landeloos, M.D., Vincent Geldhof, M.D., Helga Ceunen, Barbara Debaveye, Bert Vandenberk, M.D., Lorenz Van der Linden, Pharm.D., Sofie Jacobs, MSc., Lana Langendries, Msc., Robbert Boudewijns, Msc., Thuc Nguyen Dan Do, Msc., Winston Chiu, Msc., Xinyu Wang, Msc., Xin Zhang, Msc., Birgit Weynand, M.D., Thomas Vanassche, M.D., Timothy Devos, M.D., Geert Meyfroidt, M.D., Wim Janssens, M.D., Robin Vos, M.D., Pieter Vermeersch, M.D., Joost Wauters, M.D., Geert Verbeke, Ph.D., Paul De Munter, M.D., Suzanne J.F. Kaptein, Ph.D, Joana Rocha-Pereira, Ph.D., Leen Delang, Ph.D., Eric Van Wijngaerden, M.D., Johan Neyts, Ph.D., Peter Verhamme, M.D.
Published 2021-04-01