Rapamycin inhibits mTORC1, but not completely

by Thoreen, Carson C, Sabatini, David
Published 2012

A unifying model for mTORC1-mediated regulation of mRNA translation

by Thoreen, Carson C., Chantranupong, Lynne, Wang, Tim, Gray, Nathanael S., Keys, Heather Rochelle, Sabatini, David
Published 2014

Discovery of 9-(6-aminopyridin-3-yl)-1-(3- (trifluoromethyl)phenyl)benzo[h][1,6]naphthyridin-2(1H)-one (Torin2) as a potent, selective and orally available mTOR inhibitor for treat...

by Liu, Qingsong, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Hur, Wooyoung, Ahmed, Tausif, Gray, Nathanael S., Sabatini, David
Published 2012

DEPTOR Is an mTOR Inhibitor Frequently Overexpressed in Multiple Myeloma Cells and Required for Their Survival

by Peterson, Timothy R., Laplante, Mathieu, Thoreen, Carson C., Sancak, Yasemin, Kang, Seong A., Kuehl, W. Michael, Gray, Nathanael S., Sabatini, David M.
Published 2015

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

by Muranen, Taru, Selfors, Laura M., Hwang, Julie, Gallegos, Lisa L., Coloff, Jonathan L., Mills, Gordon B., Brugge, Joan S., Thoreen, Carson C, Kang, Seong-Cheol, Sabatini, David
Published 2018

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapa...

by Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew L., Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Gray, Nathanael S., Sabatini, David
Published 2014

Cooperative nutrient accumulation sustains growth of mammalian cells

by Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Weng, Yaochung, Wood, Kris, Vander Heiden, Matthew G., Hosios, Aaron Marc, Schweitzer, Lawrence David, Thoreen, Carson C, Sabatini, David, Manalis, Scott R
Published 2016

Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling

by Lindquist, Robert A., Ottina, Kathleen, Wheeler, Douglas B., Hsu, Peggy P., Thoreen, Carson C., Guertin, David A., Ali, Siraj M., Sengupta, Shomit, Shaul, Yoav D., Lamprecht, Michael R., Madden, Katherine L., Papallo, Adam R., Jones, Thouis R., Sabatini, David M., Carpenter, Anne E.
Published 2012

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

by Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Gray, Nathanael S., Sabatini, David, Liu, Yan
Published 2015