DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance

DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance

Abstract Background Hypoxia is pervasive in cancer and other diseases. Cells sense and adapt to hypoxia by activating hypoxia-inducible transcription factors (HIFs), but it is still an outstanding question why cell types differ in their transcriptional response to hypoxia. Results We report that HIF...

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Bibliographic Details
Main Authors: Flora D’Anna, Laurien Van Dyck, Jieyi Xiong, Hui Zhao, Rebecca V. Berrens, Junbin Qian, Pawel Bieniasz-Krzywiec, Vikas Chandra, Luc Schoonjans, Jason Matthews, Julie De Smedt, Liesbeth Minnoye, Ricardo Amorim, Sepideh Khorasanizadeh, Qian Yu, Liyun Zhao, Marie De Borre, Savvas N. Savvides, M. Celeste Simon, Peter Carmeliet, Wolf Reik, Fraydoon Rastinejad, Massimiliano Mazzone, Bernard Thienpont, Diether Lambrechts
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Genome Biology
Subjects:
DNA methylation
Hypoxia
HIF
Cryptic transcripts
Immunotherapy
Cancer
Online Access:http://link.springer.com/article/10.1186/s13059-020-02087-z

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http://link.springer.com/article/10.1186/s13059-020-02087-z

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