Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

Why does oxamniquine kill Schistosoma mansoni and not S. haematobium and S. japonicum?

Human schistosomiasis is a disease which globally affects over 229 million people. Three major species affecting humans are Schistosoma mansoni, S. haematobium and S. japonicum. Previous treatment of S. mansoni includes the use of oxamniquine (OXA), a prodrug that is enzymatically activated in S. ma...

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Bibliographic Details
Main Authors: Anastasia R. Rugel, Meghan A. Guzman, Alexander B. Taylor, Frédéric D. Chevalier, Reid S. Tarpley, Stanton F. McHardy, Xiaohang Cao, Stephen P. Holloway, Timothy J.C. Anderson, P. John Hart, Philip T. LoVerde
Format: Article
Language:English
Published: Elsevier 2020-08-01
Series:International Journal for Parasitology: Drugs and Drug Resistance
Subjects:
Schistosoma spp.
Drug binding
Oxamniquine
Sulfotransferase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211320720300063

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http://www.sciencedirect.com/science/article/pii/S2211320720300063

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