Deconvolution of bulk blood eQTL effects into immune cell subpopulations

Deconvolution of bulk blood eQTL effects into immune cell subpopulations

Abstract Background Expression quantitative trait loci (eQTL) studies are used to interpret the function of disease-associated genetic risk factors. To date, most eQTL analyses have been conducted in bulk tissues, such as whole blood and tissue biopsies, which are likely to mask the cell type-contex...

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Main Authors: Raúl Aguirre-Gamboa, Niek de Klein, Jennifer di Tommaso, Annique Claringbould, Monique GP van der Wijst, Dylan de Vries, Harm Brugge, Roy Oelen, Urmo Võsa, Maria M. Zorro, Xiaojin Chu, Olivier B. Bakker, Zuzanna Borek, Isis Ricaño-Ponce, Patrick Deelen, Cheng-Jiang Xu, Morris Swertz, Iris Jonkers, Sebo Withoff, Irma Joosten, Serena Sanna, Vinod Kumar, Hans J. P. M. Koenen, Leo A. B. Joosten, Mihai G. Netea, Cisca Wijmenga, BIOS Consortium, Lude Franke, Yang Li
Format: Article
Language:English
Published: BMC 2020-06-01
Series:BMC Bioinformatics
Subjects:
eQTL
Deconvolution
Cell types
Immune cells
Online Access:http://link.springer.com/article/10.1186/s12859-020-03576-5

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http://link.springer.com/article/10.1186/s12859-020-03576-5

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