Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression

PD-L1 and PD-L2 are ligands for the PD-1 immune inhibiting checkpoint that can be induced in tumors by interferon exposure, leading to immune evasion. This process is important for immunotherapy based on PD-1 blockade. We examined the specific molecules involved in interferon-induced signaling that...

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Bibliographic Details
Main Authors: Angel Garcia-Diaz, Daniel Sanghoon Shin, Blanca Homet Moreno, Justin Saco, Helena Escuin-Ordinas, Gabriel Abril Rodriguez, Jesse M. Zaretsky, Lu Sun, Willy Hugo, Xiaoyan Wang, Giulia Parisi, Cristina Puig Saus, Davis Y. Torrejon, Thomas G. Graeber, Begonya Comin-Anduix, Siwen Hu-Lieskovan, Robert Damoiseaux, Roger S. Lo, Antoni Ribas
Format: Article
Language:English
Published: Elsevier 2017-05-01
Series:Cell Reports
Subjects:
PD-1
PD-L1
PD-L2
interferon receptor signaling pathways
JAK-STATs
IRF1
immunotherapy
melanoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717305259

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http://www.sciencedirect.com/science/article/pii/S2211124717305259

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