Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

Manipulating the Selection Forces during Affinity Maturation to Generate Cross-Reactive HIV Antibodies

Generation of potent antibodies by a mutation-selection process called affinity maturation is a key component of effective immune responses. Antibodies that protect against highly mutable pathogens must neutralize diverse strains. Developing effective immunization strategies to drive their evolution...

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Main Authors: Wang, Shenshen (Contributor), Mata-Fink, Jordi (Contributor), Kriegsman, Barry (Contributor), Irvine, Darrell J (Author), Eisen, Herman N (Author), Burton, Dennis R (Author), Kardar, Mehran (Contributor), Chakraborty, Arup K (Author), Wittrup, Karl Dane (Contributor), Eisen, Herman N. (Contributor), Hanson, Melissa Catherine (Author), Irvine, Darrell J (Author), Chakraborty, Arup K (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Chemical Engineering (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Ragon Institute of MGH, MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Hanson, Melissa (Contributor), Irvine, Darrell J. (Contributor), Chakraborty, Arup K. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2016-03-24T14:57:45Z.
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