Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

The mTORC1 kinase promotes growth in response to growth factors, energy levels, and amino acids, and its activity is often deregulated in disease. The Rag GTPases interact with mTORC1 and are proposed to activate it in response to amino acids by promoting mTORC1 translocation to a membrane-bound com...

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Bibliographic Details
Main Authors: Sancak, Yasemin (Contributor), Bar-Peled, Liron (Contributor), Zoncu, Roberto (Contributor), Markhard, Andrew L. (Contributor), Nada, Shigeyuki (Author), Sabatini, David (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor), Sabatini, David M. (Contributor)
Format: Article
Language:English
Published: Elsevier, 2012-11-01T16:57:33Z.
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