Cooperative nutrient accumulation sustains growth of mammalian cells

by Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Weng, Yaochung, Wood, Kris, Vander Heiden, Matthew G., Hosios, Aaron Marc, Schweitzer, Lawrence David, Thoreen, Carson C, Sabatini, David, Manalis, Scott R
Published 2016

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

by Freinkman, Elizaveta, Comb, William C, Cantor, Jason R, Tam, Wai Leong, Thiru, Prathapan, Kanarek, Naama, Bierie, Brian, Shaul, Yoav, Kim, Dohoon, Chen, Walter W., Possemato, Richard, Reinhardt, Ferenc, Weinberg, Robert A, Yaffe, Michael B, Sabatini, David, Pacold, Michael Edward
Published 2017

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

by Freinkman, Elizaveta, Birsoy, Kıvanç, Chen, Walter W., Wang, Tim, Sabatini, David
Published 2018

Growth signaling at the nexus of stem cell life and death

by Wood, Kris C., Sabatini, David
Published 2009

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

by Saadatpour, Assieh, Hong, Sue-Jean, Pinello, Luca, Katz, Yarden, Lamming, Dudley W., Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Beyaz, Semir, Mana, Miyeko, Roper, Jatin, Kedrin, Dmitriy, Bauer-Rowe, Khristian E., Xifaras, Michael, Akkad, Adam, Arias, Erika, Shinagare, Shweta, Abu-Remaileh, Monther, Dogum, Rizkullah, Sabatini, David, Yilmaz, Omer, Mihaylova, Maria M.
Published 2017

Sestrin2 is a leucine sensor for the mTORC1 pathway

by Shen, K., Cantor, J. R., Wolfson, Rachel Laura, Chantranupong, Lynne, Saxton, Robert Andrew, Scaria, Sonia M., Sabatini, David
Published 2017

Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability

by Shen, Kuang, Choe, Abigail D., Sabatini, David
Published 2018

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

by Wang, Tim, Wei, Jenny J., Sabatini, David, Lander, Eric Steven
Published 2015

A genome-wide CRISPR screen identifies a restricted set of HIV host dependency factors

by Park, Ryan J, Koundakjian, Dylan, Hultquist, Judd F, Lamothe-Molina, Pedro, Monel, Blandine, Schumann, Kathrin, Yu, Haiyan, Krupzcak, Kevin M, Garcia-Beltran, Wilfredo, Piechocka-Trocha, Alicja, Krogan, Nevan J, Marson, Alexander, Hacohen, Nir, Walker, Bruce D, Wang, Tim, Sabatini, David, Lander, Eric Steven
Published 2018

A Radical Role for TOR in Longevity

by Lamming, Dudley W, Sabatini, David M, Sabatini, David
Published 2014

SAMTOR is an S-adenosylmethionine sensor for the mTORC1 pathway

by Harper, J. Wade, Gygi, Steven P., Gu, Xin, Orozco Segrera, Jose, Saxton, Robert Andrew, Condon, Kendall Janine, Liu, Grace Yun, Krawczyk, Patrycja A., Scaria, Sonia M., Sabatini, David
Published 2019

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

by Chantranupong, Lynne, Orozco, Jose M, Scaria, Sonia M, Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M, Wolfson, Rachel Laura, Saxton, Robert Andrew, Scaria, Sonia M., Sabatini, David
Published 2015

mTOR and cancer: many loops in one pathway

by Efeyan, Alejo, Sabatini, David
Published 2012

A Central Role for mTOR in Lipid Homeostasis

by Lamming, Dudley W, Sabatini, David M, Lamming, Dudley W., Sabatini, David
Published 2016

Nutrient-Sensing Mechanisms across Evolution

by Chantranupong, Lynne, Wolfson, Rachel Laura, Sabatini, David
Published 2016

Viral Packaging and Cell Culture for CRISPR-Based Screens

by Wang, Tim, Lander, Eric Steven, Sabatini, David
Published 2016

mTOR Signaling in Growth, Metabolism, and Disease

by Saxton, Robert Andrew, Sabatini, David
Published 2018

Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1

by Plovanich, M. E., Straub, C., Sabatini, B. L., Tsun, Zhi-Yang, Wang, Shuyu, Wolfson, Rachel Laura, Shen, Kuang, Wyant, Gregory Andrew, Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William C., Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Kim, Choah, Park, Jiwon, Sabatini, David
Published 2015

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

by Kami, Kenjiro, Shelton, Laura M., Ramkissoon, Shakti H., Ligon, Keith L., Snuderl, Matija, Kim, Dohoon, Fiske, Brian Prescott, Birsoy, Kivanc, Freinkman, Elizaveta, Possemato, Richard, Chudnovsky, Yakov, Chen, Walter W., Cantor, Jason R., Gui, Dan Yi, Kwon, ManJae, Kang, Seong Woo, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Published 2017

Rag proteins regulate amino-acid-induced mTORC1 signalling

by Sancak, Yasemin, Sabatini, David
Published 2011