cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages

by Peifa Yu, Zhijiang Miao, Yang Li, Ruchi Bansal, Maikel P. Peppelenbosch, Qiuwei Pan
Published 2021-01-01

Distinct gut microbial compositional and functional changes associated with impaired inhibitory control in patients with cirrhosis

by Jasmohan S Bajaj, Amirhossein Shamsaddini, Andrew Fagan, Sara McGeorge, Edith Gavis, Masoumeh Sikaroodi, Lisa A. Brenner, James B Wade, Patrick M Gillevet
Published 2021-01-01

Chronic opioid use modulates human enteric microbiota and intestinal barrier integrity

by Angélica Cruz-Lebrón, Ramona Johnson, Claire Mazahery, Zach Troyer, Samira Joussef-Piña, Miguel E. Quiñones-Mateu, Christopher M Strauch, Stanley L. Hazen, Alan D. Levine
Published 2021-01-01

Gut microbiota shape the inflammatory response in mice with an epithelial defect

by Ran Wang, Md Moniruzzaman, Kuan Yau Wong, Percival Wiid, Alexa Harding, Rabina Giri, Wendy (Hui) Tong, Jackie Creagh, Jakob Begun, Michael A. McGuckin, Sumaira Z. Hasnain
Published 2021-01-01

Microbiome distinctions between the CRC carcinogenic pathways

by Lauren DeDecker, Bretton Coppedge, Julio Avelar-Barragan, William Karnes, Katrine Whiteson
Published 2021-01-01

A bovine lactoferricin-lactoferrampin-encoding Lactobacillus reuteri CO21 regulates the intestinal mucosal immunity and enhances the protection of piglets against enterotoxigenic E...

by Weichun Xie, Liying Song, Xueying Wang, Yigang Xu, Zengsu Liu, Dongfang Zhao, Shubo Wang, Xiaolong Fan, Zhaorui Wang, Chong Gao, Xiaona Wang, Li Wang, Xinyuan Qiao, Han Zhou, Wen Cui, Yanping Jiang, Yijing Li, Lijie Tang
Published 2021-01-01

A double-blind, 377-subject randomized study identifies Ruminococcus, Coprococcus, Christensenella, and Collinsella as long-term potential key players in the modulation of the gut...

by M. A. Azcarate-Peril, J. Roach, A. Marsh, William D. Chey, William J. Sandborn, Andrew J. Ritter, Dennis A. Savaiano, T. R. Klaenhammer
Published 2021-01-01

Statins significantly repress rotavirus replication through downregulation of cholesterol synthesis

by Shihao Ding, Bingting Yu, Anneke J. van Vuuren
Published 2021-01-01

Decrease in acetyl-CoA pathway utilizing butyrate-producing bacteria is a key pathogenic feature of alcohol-induced functional gut microbial dysbiosis and development of liver dise...

by Richa Singhal, Hridgandh Donde, Smita Ghare, Kendall Stocke, Jingwein Zhang, Manicka Vadhanam, Sreelatha Reddy, Leila Gobejishvili, Paula Chilton, Swati Joshi-Barve, Wenke Feng, Craig McClain, Kristi Hoffman, Joseph Petrosino, Marius Vital, Shirish Barve
Published 2021-01-01

Lacticaseibacillus paracasei DG enhances the lactoferrin anti-SARS-CoV-2 response in Caco-2 cells

by Claudio Salaris, Melania Scarpa, Marina Elli, Alice Bertolini, Simone Guglielmetti, Fabrizio Pregliasco, Paola Brun, Ignazio Castagliuolo
Published 2021-01-01

Dysbiotic microbiota interactions in Crohn’s disease

by Esther Caparrós, Reiner Wiest, Michael Scharl, Gerhard Rogler, Ana Gutiérrez Casbas, Bahtiyar Yilmaz, Marcin Wawrzyniak, Rubén Francés
Published 2021-01-01

A combination of fecal calprotectin and human beta-defensin 2 facilitates diagnosis and monitoring of inflammatory bowel disease

by R. Gacesa, A. Vich Vila, V. Collij, Z. Mujagic, A. Kurilshikov, M.D. Voskuil, E.A.M. Festen, C. Wijmenga, D.M.A.E. Jonkers, G. Dijkstra, J. Fu, A. Zhernakova, F. Imhann, R.K. Weersma
Published 2021-01-01

Investigating causality with fecal microbiota transplantation in rodents: applications, recommendations and pitfalls

by Cassandra E. Gheorghe, Nathaniel L. Ritz, Jason A. Martin, Hannah R. Wardill, John F. Cryan, Gerard Clarke
Published 2021-01-01

Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance

by S. Raj J. Trikha, Dustin M. Lee, Kayl E. Ecton, Scott D. Wrigley, Allegra R. Vazquez, Nicole S. Litwin, Keely N. Thomas, Yuren Wei, Micah L. Battson, Sarah A. Johnson, Kristine A. Kuhn, Sean P. Colgan, Christopher L. Gentile, Tiffany L. Weir
Published 2021-01-01

Roux-en-Y gastric bypass surgery in Zucker rats induces bacterial and systemic metabolic changes independent of caloric restriction-induced weight loss

by Florian Seyfried, Jutarop Phetcharaburanin, Maria Glymenaki, Arno Nordbeck, Mohammed Hankir, Jeremy K Nicholson, Elaine Holmes, Julian R. Marchesi, Jia V. Li
Published 2021-01-01

Cohousing-mediated microbiota transfer from milk bioactive components-dosed mice ameliorate colitis by remodeling colonic mucus barrier and lamina propria macrophages

by Cong Liu, Shimeng Huang, Zhenhua Wu, Tiantian Li, Na Li, Bing Zhang, Dandan Han, Shilan Wang, Jiangchao Zhao, Junjun Wang
Published 2021-01-01

The prognostic value of toxin B and binary toxin in Clostridioides difficile infection

by Salvador López-Cárdenas, Eva Torres-Martos, Juan Mora-Delgado, Juan Manuel Sánchez-Calvo, Marta Santos-Peña, Ángel Zapata López, María Dolores López-Prieto, Salvador Pérez-Cortés, Juan Carlos Alados
Published 2021-01-01

Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin−ferroportin axis

by Qifeng Deng, Sidi Yang, Lanqing Sun, Kedi Dong, Yuanyuan Li, Shuyan Wu, Rui Huang
Published 2021-01-01

Intestinal and systemic inflammation induced by symptomatic and asymptomatic enterotoxigenic E. coli infection and impact on intestinal colonization and ETEC specific immune respon...

by Jessica Brubaker, Xueyan Zhang, A. Louis Bourgeois, Clayton Harro, David A Sack, Subhra Chakraborty
Published 2021-01-01

The gut virome in Irritable Bowel Syndrome differs from that of controls

by S. Coughlan, A. Das, E. O’Herlihy, F. Shanahan, P.W. O’Toole, I.B. Jeffery
Published 2021-01-01