Intrinsic Resistance to Immune Checkpoint Blockade in a Mismatch Repair-Deficient Colorectal Cancer

by Liu, David, Regev, Aviv
Published 2020

Aneuploid Cell Survival Relies upon Sphingolipid Homeostasis

by Tang, Yun-Chi, Yuwen, Hui, Wang, Kaiying, Bruno, Peter M., Bullock, Kevin, Deik, Amy, Zhong, Na, Huang, Tao, Wang, Lan, Clish, Clary B., Hemann, Michael T., Santaguida, Stefano, Trakala, Marianna, Pfau, Sarah Jeanne, Amon, Angelika B
Published 2018

Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer

by Emmons, Tiffany R, Giridharan, Thejaswini, Singel, Kelly L, Khan, ANM Nazmul H, Ricciuti, Jason, Howard, Kaitlyn, Silva-Del Toro, Stephanie L, Debreceni, Ivy L, Aarts, Cathelijn EM, Brouwer, Mieke C, Suzuki, Sora, Kuijpers, Taco W, Jongerius, Ilse, Allen, Lee-Ann H, Ferreira, Viviana P, Schubart, Anna, Sellner, Holger, Eder, Jörg, Holland, Steven M, Ram, Sanjay, Lederer, James A, Eng, Kevin H, Moysich, Kirsten B, Odunsi, Kunle, Yaffe, Michael B, Zsiros, Emese, Segal, Brahm H
Published 2021

High-density, targeted monitoring of tyrosine phosphorylation reveals activated signaling networks in human tumors

by Stopfer, Lauren E, Flower, Cameron T, Gajadhar, Aaron S, Patel, Bhavin, Gallien, Sebastien, Lopez-Ferrer, Daniel, White, Forest M
Published 2021

Tissue-Specific Oncogenic Activity of KRASA146T

by Poulin, Emily J., Bera, Asim K., Lu, Jia, Lin, Yi-Jang, Strasser, Samantha Dale, Paulo, Joao A., Huang, Tannie Q., Morales, Carolina, Yan, Wei, Cook, Joshua, Nowak, Jonathan A., Brubaker, Douglas K., Joughin, Brian Alan, Johnson, Christian W., DeStefanis, Rebecca A., Ghazi, Phaedra C., Gondi, Sudershan, Wales, Thomas E., Iacob, Roxana E., Bogdanova, Lana, Gierut, Jessica J., Li, Yina, Engen, John R., Perez-Mancera, Pedro A., Braun, Benjamin S., Gygi, Steven P., Lauffenburger, Douglas A, Westover, Kenneth D., Haigis, Kevin M.
Published 2020

A Combination RNAi-Chemotherapy Layer-by-Layer Nanoparticle for Systemic Targeting of KRAS/P53 with Cisplatin to Treat Non-Small Cell Lung Cancer

by Gu, Li, Deng, Zhou J., Roy, Sweta, Hammond, Paula T
Published 2021

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP

by Muranen, Taru, Selfors, Laura M., Hwang, Julie, Gallegos, Lisa L., Coloff, Jonathan L., Mills, Gordon B., Brugge, Joan S., Thoreen, Carson C, Kang, Seong-Cheol, Sabatini, David
Published 2018

Postdiagnosis Loss of Skeletal Muscle, but Not Adipose Tissue, Is Associated with Shorter Survival of Patients with Advanced Pancreatic Cancer

by Babic, Ana, Rosenthal, Michael H., Bamlet, William R., Takahashi, Naoki, Sugimoto, Motokazu, Danai, Laura V., Morales-Oyarvide, Vicente, Khalaf, Natalia, Dunne, Richard F., Brais, Lauren K., Welch, Marisa W., Zellers, Caitlin L., Dennis, Courtney, Rifai, Nader, Prado, Carla M., Caan, Bette, Sundaresan, Tilak K., Meyerhardt, Jeffrey A., Kulke, Matthew H., Clish, Clary B., Ng, Kimmie, Vander Heiden, Matthew G., Petersen, Gloria M., Wolpin, Brian M.
Published 2020

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

by Shibue, Tsukasa, Brooks, Mary W., Inan, M. Fatih, Reinhardt, Ferenc, Weinberg, Robert A
Published 2018

Roles for Innate Immunity in Combination Immunotherapies

by Moynihan, Kelly Dare, Irvine, Darrell J
Published 2018

Characterization of in vivo resistance to osimertinib and JNJ-61186372, an EGFR/Met bi-specific antibody, reveals unique and consensus mechanisms of resistance

by Moores, Sheri L., Laquerre, Sylvie, Emdal, Kristina Bennet, Dittmann, Antje, Reddy, Raven J., Lescarbeau, Rebecca S., White, Forest M.
Published 2018

Cancer Cell-Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

by Tian, Chenxi, Öhlund, Daniel, Rickelt, Steffen, Lidström, Tommy, Huang, Ying, Hao, Liangliang, Zhao, Renee T, Franklin, Oskar, Bhatia, Sangeeta N, Tuveson, David A., Hynes, Richard O
Published 2020

iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer

by Lo, Justin H., Hao, Liangliang, Muzumdar, Mandar, Raghavan, Srivatsan, Kwon, Ester, Pulver, Emilia M, Hsu, Felicia, Aguirre, Andrew J., Wolpin, Brian M., Fuchs, Charles S., Hahn, William C., Jacks, Tyler E, Bhatia, Sangeeta N
Published 2020

A Novel Small Molecule Activator of Nuclear Receptor SHP Inhibits HCC Cell Migration via Suppressing Ccl2

by Yang, Zhihong, Koehler, Angela Nicole, Wang, Li
Published 2020

DNA repair capacity in multiple pathways predicts chemoresistance in glioblastoma multiforme

by Kitange, Gaspar J., Gupta, Shiv K., Sarkaria, Jann N., Nagel, Zachary D., Joughin, Brian Alan, Chaim, Isaac Alexander, Mazzucato, Patrizia, Lauffenburger, Douglas A, Samson, Leona D
Published 2016

Gene Expression Pathways in Prostate Tissue Associated with Vigorous Physical Activity in Prostate Cancer

by Pernar, Claire H, Parmigiani, Giovanni, Giovannucci, Edward L, Rimm, Eric B, Tyekucheva, Svitlana, Loda, Massimo, Finn, Stephen P, Heiden, Matthew G Vander, Fiorentino, Michelangelo, Ebot, Ericka M, Mucci, Lorelei A
Published 2021

A Human Ribonuclease Variant and ERK-Pathway Inhibitors Exhibit Highly Synergistic Toxicity for Cancer Cells

by Hoang, Trish T., Tanrikulu, Ismet Caglar, Vatland, Quinn A., Hoang, Trieu M., Raines, Ronald T
Published 2020

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

by Jaeger, Alex M., Stopfer, Lauren Elizabeth, Lee, Sunmin, Gaglia, Giorgio, Sandel, Demi, Santagata, Sandro, Lin, Nancy U., Trepel, Jane B., White, Forest M., Jacks, Tyler E, Lindquist, Susan, Whitesell, Luke
Published 2020

Apoptotic Bodies Elicit Gas6-Mediated Migration of AXL-Expressing Tumor Cells

by French, Cory B., Zweemer, Jacomina M., Mesfin, Joshua, Gordonov, Simon, Meyer, Aaron Samuel, Lauffenburger, Douglas A
Published 2018

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation

by Tech, Katherine, Tikunov, Andrey P., Farooq, Hamza, Morrissy, A. Sorana, Meidinger, Jessica, Fish, Taylor, Green, Sarah C., Liu, Hedi, Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M, Marra, Marco A., Vander Heiden, Matthew G., Taylor, Michael D., Macdonald, Jeffrey M., Gershon, Timothy R.
Published 2018