Intranasal immunization with peptide-based immunogenic complex enhances BCG vaccine efficacy in a murine model of tuberculosis

by Santosh Kumar, Ashima Bhaskar, Gautam Patnaik, Chetan Sharma, Dhiraj Kumar Singh, Sandeep Rai Kaushik, Shivam Chaturvedi, Gobardhan Das, Ved Prakash Dwivedi
Published 2021-02-01

B cells modulate mouse allergen-specific T cells in nonallergic laboratory animal-care workers

by Esther Dawen Yu, Luise Westernberg, Alba Grifoni, April Frazier, Aaron Sutherland, Eric Wang, Bjoern Peters, Ricardo da Silva Antunes, Alessandro Sette
Published 2021-02-01

Immunopathogenic CSF TCR repertoire signatures in virus-associated neurologic disease

by Satoshi Nozuma, Yoshimi Enose-Akahata, Kory R. Johnson, Maria Chiara Monaco, Nyater Ngouth, Abdel Elkahloun, Joan Ohayon, Jun Zhu, Steven Jacobson
Published 2021-02-01

Vagal gut-brain signaling mediates amygdaloid plasticity, affect, and pain in a functional dyspepsia model

by Zachary A. Cordner, Qian Li, Liansheng Liu, Kellie L. Tamashiro, Aditi Bhargava, Timothy H. Moran, Pankaj Jay Pasricha
Published 2021-03-01

Distinct antibody repertoires against endemic human coronaviruses in children and adults

by Taushif Khan, Mahbuba Rahman, Fatima Al Ali, Susie S. Y. Huang, Manar Ata, Qian Zhang, Paul Bastard, Zhiyong Liu, Emmanuelle Jouanguy, Vivien Béziat, Aurélie Cobat, Gheyath K. Nasrallah, Hadi M. Yassine, Maria K. Smatti, Amira Saeed, Isabelle Vandernoot, Jean-Christophe Goffard, Guillaume Smits, Isabelle Migeotte, Filomeen Haerynck, Isabelle Meyts, Laurent Abel, Jean-Laurent Casanova, Mohammad R. Hasan, Nico Marr
Published 2021-02-01

Inhibition of astrocyte hemichannel improves recovery from spinal cord injury

by Chao Zhang, Zhao Yan, Asif Maknojia, Manuel A. Riquelme, Sumin Gu, Grant Booher, David J. Wallace, Viktor Bartanusz, Akshay Goswami, Wei Xiong, Ningyan Zhang, Michael J. Mader, Zhiqiang An, Naomi L. Sayre, Jean X. Jiang
Published 2021-03-01

Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury

by Temesgen E. Andargie, Naoko Tsuji, Fayaz Seifuddin, Moon Kyoo Jang, Peter S.T. Yuen, Hyesik Kong, Ilker Tunc, Komudi Singh, Ananth Charya, Kenneth Wilkins, Steven Nathan, Andrea Cox, Mehdi Pirooznia, Robert A. Star, Sean Agbor-Enoh
Published 2021-04-01

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice

by Haixia Zhang, Alex Hanson, Tobias Scherf de Almeida, Christopher Emfinger, Conor McClenaghan, Theresa Harter, Zihan Yan, Paige E. Cooper, G. Schuyler Brown, Eric C. Arakel, Robert P. Mecham, Atilla Kovacs, Carmen M. Halabi, Blanche Schwappach, Maria S. Remedi, Colin G. Nichols
Published 2021-03-01

Differential role of MLKL in alcohol-associated and non–alcohol-associated fatty liver diseases in mice and humans

by Tatsunori Miyata, Xiaoqin Wu, Xiude Fan, Emily Huang, Carlos Sanz-Garcia, Christina K. Cajigas-Du Ross, Sanjoy Roychowdhury, Annette Bellar, Megan R. McMullen, Jaividhya Dasarathy, Daniela S. Allende, Joan Caballeria, Pau Sancho-Bru, Craig J. McClain, Mack Mitchell, Arthur J. McCullough, Svetlana Radaeva, Bruce Barton, Gyongyi Szabo, Srinivasan Dasarathy, Laura E. Nagy
Published 2021-02-01

Neural stem cell–specific ITPA deficiency causes neural depolarization and epilepsy

by Yuichiro Koga, Daisuke Tsuchimoto, Yoshinori Hayashi, Nona Abolhassani, Yasuto Yoneshima, Kunihiko Sakumi, Hiroshi Nakanishi, Shinya Toyokuni, Yusaku Nakabeppu
Published 2020-11-01

Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat

by Anna D. Manis, Oleg Palygin, Elena Isaeva, Vladislav Levchenko, Peter S. LaViolette, Tengis S. Pavlov, Matthew R. Hodges, Alexander Staruschenko
Published 2021-01-01

Pseudo-obstruction–inducing ACTG2R257C alters actin organization and function

by Sohaib Khalid Hashmi, Vasia Barka, Changsong Yang, Sabine Schneider, Tatyana M. Svitkina, Robert O. Heuckeroth
Published 2020-08-01

Early disruption of nerve mitochondrial and myelin lipid homeostasis in obesity-induced diabetes

by Juan P. Palavicini, Juan Chen, Chunyan Wang, Jianing Wang, Chao Qin, Eric Baeuerle, Xinming Wang, Jung A. Woo, David E. Kang, Nicolas Musi, Jeffrey L. Dupree, Xianlin Han
Published 2020-11-01

Matrin 3 in neuromuscular disease: physiology and pathophysiology

by Ahmed M. Malik, Sami J. Barmada
Published 2021-01-01

LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation

by Muchaala Yeboah, Charys Papagregoriou, Des C. Jones, H.T. Claude Chan, Guangan Hu, Justine S. McPartlan, Torbjörn Schiött, Ulrika Mattson, C. Ian Mockridge, Ulla-Carin Tornberg, Björn Hambe, Anne Ljungars, Mikael Mattsson, Ivo Tews, Martin J. Glennie, Stephen M. Thirdborough, John Trowsdale, Björn Frendeus, Jianzhu Chen, Mark S. Cragg, Ali Roghanian
Published 2020-09-01

Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin

by Yanyun Jiang, Lam C. Tsoi, Allison C. Billi, Nicole L. Ward, Paul W. Harms, Chang Zeng, Emanual Maverakis, J. Michelle Kahlenberg, Johann E. Gudjonsson
Published 2020-10-01

Germline biallelic Mcm8 variants are associated with early-onset Lynch-like syndrome

by Mariano Golubicki, Laia Bonjoch, José G. Acuña-Ochoa, Marcos Díaz-Gay, Jenifer Muñoz, Miriam Cuatrecasas, Teresa Ocaña, Soledad Iseas, Guillermo Mendez, Daniel Cisterna, Stephanie A. Schubert, Maartje Nielsen, Tom van Wezel, Yael Goldberg, Eli Pikarsky, Juan Robbio, Enrique Roca, Antoni Castells, Francesc Balaguer, Marina Antelo, Sergi Castellví-Bel
Published 2020-09-01

KrasP34R and KrasT58I mutations induce distinct RASopathy phenotypes in mice

by Jasmine C. Wong, Pedro A. Perez-Mancera, Tannie Q. Huang, Jangkyung Kim, Joaquim Grego-Bessa, Maria del pilar Alzamora, Scott C. Kogan, Amnon Sharir, Susan H. Keefe, Carolina E. Morales, Denny Schanze, Pau Castel, Kentaro Hirose, Guo N. Huang, Martin Zenker, Dean Sheppard, Ophir D. Klein, David A. Tuveson, Benjamin S. Braun, Kevin Shannon
Published 2020-11-01

Ovarian granulosa cell tumor characterization identifies FOXL2 as an immunotherapeutic target

by Stefano Pierini, Janos L. Tanyi, Fiona Simpkins, Erin George, Mireia Uribe-Herranz, Ronny Drapkin, Robert Burger, Mark A. Morgan, Andrea Facciabene
Published 2020-08-01

Chamber-specific transcriptional responses in atrial fibrillation

by Catherine E. Lipovsky, Jesus Jimenez, Qiusha Guo, Gang Li, Tiankai Yin, Stephanie C. Hicks, Somya Bhatnagar, Kentaro Takahashi, David M. Zhang, Brittany D. Brumback, Uri Goldsztejn, Rangarajan D. Nadadur, Carlos Perez-Cervantez, Ivan P. Moskowitz, Shaopeng Liu, Bo Zhang, Stacey L. Rentschler
Published 2020-09-01