IL-37 inhibits inflammasome activation and disease severity in murine aspergillosis.

by Silvia Moretti, Silvia Bozza, Vasilis Oikonomou, Giorgia Renga, Andrea Casagrande, Rossana G Iannitti, Matteo Puccetti, Cecilia Garlanda, Soohyun Kim, Suzhao Li, Frank L van de Veerdonk, Charles A Dinarello, Luigina Romani
Published 2014-11-01

The Absence of NOD1 Enhances Killing of Aspergillus fumigatus Through Modulation of Dectin-1 Expression

by Mark S. Gresnigt, Mark S. Gresnigt, Martin Jaeger, R. K. Subbarao Malireddi, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Willem J. G. Melchers, Thirumala-Devi Kanneganti, Agostinho Carvalho, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdonk
Published 2017-12-01

Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model

by Laura Seldeslachts, Lore Vanderbeke, Astrid Fremau, Agustin Reséndiz-Sharpe, Cato Jacobs, Bo Laeveren, Tessa Ostyn, Lieve Naesens, Matthias Brock, Frank L. Van De Veerdonk, Stephanie Humblet-Baron, Erik Verbeken, Katrien Lagrou, Joost Wauters, Greetje Vande Velde
Published 2021-01-01

Comparative host transcriptome in response to pathogenic fungi identifies common and species-specific transcriptional antifungal host response pathways

by Mariolina Bruno, Intan M.W. Dewi, Vicky Matzaraki, Rob ter Horst, Marina Pekmezovic, Berenice Rösler, Laszlo Groh, Rutger J. Röring, Vinod Kumar, Yang Li, Agostinho Carvalho, Mihai G. Netea, Jean-Paul Latgé, Mark S. Gresnigt, Frank L. van de Veerdonk
Published 2021-01-01

Rewiring monocyte glucose metabolism via C-type lectin signaling protects against disseminated candidiasis.

by Jorge Domínguez-Andrés, Rob J W Arts, Rob Ter Horst, Mark S Gresnigt, Sanne P Smeekens, Jacqueline M Ratter, Ekta Lachmandas, Lily Boutens, Frank L van de Veerdonk, Leo A B Joosten, Richard A Notebaart, Carlos Ardavín, Mihai G Netea
Published 2017-09-01

Anakinra treatment in critically ill COVID-19 patients: a prospective cohort study

by Emma J. Kooistra, Nicole J. B. Waalders, Inge Grondman, Nico A. F. Janssen, Aline H. de Nooijer, Mihai G. Netea, Frank L. van de Veerdonk, Esther Ewalds, Johannes G. van der Hoeven, Matthijs Kox, Peter Pickkers, the RCI-COVID-19 Study Group
Published 2020-12-01

STAT1 hyperphosphorylation and defective IL12R/IL23R signaling underlie defective immunity in autosomal dominant chronic mucocutaneous candidiasis.

by Sanne P Smeekens, Theo S Plantinga, Frank L van de Veerdonk, Bas Heinhuis, Alexander Hoischen, Leo A B Joosten, Peter D Arkwright, Andrew Gennery, Bart Jan Kullberg, Joris A Veltman, Desa Lilic, Jos W M van der Meer, Mihai G Netea
Published 2011-01-01

Anakinra Activates Superoxide Dismutase 2 to Mitigate Inflammasome Activity

by Marilena Pariano, Stefania Pieroni, Antonella De Luca, Rossana G. Iannitti, Monica Borghi, Matteo Puccetti, Stefano Giovagnoli, Giorgia Renga, Fiorella D’Onofrio, Marina M. Bellet, Claudia Stincardini, Maria Agnese Della-Fazia, Giuseppe Servillo, Frank L. van de Veerdonk, Claudio Costantini, Luigina Romani
Published 2021-06-01

Impact of rare and common genetic variation in the interleukin-1 pathway on human cytokine responses

by Rosanne C. van Deuren, Peer Arts, Giulio Cavalli, Martin Jaeger, Marloes Steehouwer, Maartje van de Vorst, Christian Gilissen, Leo A. B. Joosten, Charles A. Dinarello, Musa M. Mhlanga, Vinod Kumar, Mihai G. Netea, Frank L. van de Veerdonk, Alexander Hoischen
Published 2021-05-01

A polysaccharide virulence factor from Aspergillus fumigatus elicits anti-inflammatory effects through induction of Interleukin-1 receptor antagonist.

by Mark S Gresnigt, Silvia Bozza, Katharina L Becker, Leo A B Joosten, Shahla Abdollahi-Roodsaz, Wim B van der Berg, Charles A Dinarello, Mihai G Netea, Thierry Fontaine, Antonella De Luca, Silvia Moretti, Luigina Romani, Jean-Paul Latge, Frank L van de Veerdonk
Published 2014-03-01

Genetic Screening for TLR7 Variants in Young and Previously Healthy Men With Severe COVID-19

by Xavier Solanich, Gardenia Vargas-Parra, Gardenia Vargas-Parra, Caspar I. van der Made, Caspar I. van der Made, Caspar I. van der Made, Annet Simons, Janneke Schuurs-Hoeijmakers, Arnau Antolí, Jesús del Valle, Jesús del Valle, Gemma Rocamora-Blanch, Fernando Setién, Manel Esteller, Manel Esteller, Manel Esteller, Manel Esteller, Simon V. van Reijmersdal, Antoni Riera-Mestre, Antoni Riera-Mestre, Joan Sabater-Riera, Gabriel Capellá, Gabriel Capellá, Frank L. van de Veerdonk, Frank L. van de Veerdonk, Ben van der Hoven, Xavier Corbella, Xavier Corbella, Alexander Hoischen, Alexander Hoischen, Alexander Hoischen, Conxi Lázaro, Conxi Lázaro
Published 2021-07-01

An integrative genomics approach identifies novel pathways that influence candidaemia susceptibility.

by Vasiliki Matzaraki, Mark S Gresnigt, Martin Jaeger, Isis Ricaño-Ponce, Melissa D Johnson, Marije Oosting, Lude Franke, Sebo Withoff, John R Perfect, Leo A B Joosten, Bart Jan Kullberg, Frank L van de Veerdonk, Iris Jonkers, Yang Li, Cisca Wijmenga, Mihai G Netea, Vinod Kumar
Published 2017-01-01

Lysine methyltransferase G9a is an important modulator of trained immunity

by Vera P Mourits, Jelmer H vanPuffelen, Boris Novakovic, Mariolina Bruno, Anaísa V Ferreira, Rob JW Arts, Laszlo Groh, Tania O Crișan, Jelle Zwaag, Elisa Jentho, Matthijs Kox, Peter Pickkers, Frank L van deVeerdonk, Sebastian Weis, Egbert Oosterwijk, Sita H Vermeulen, Mihai G Netea, Leo AB Joosten
Published 2021-01-01

Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

by Mark S. Gresnigt, Cristina Cunha, Martin Jaeger, Samuel M. Gonçalves, R. K. Subbarao Malireddi, Anne Ammerdorffer, Rosalie Lubbers, Marije Oosting, Orhan Rasid, Grégory Jouvion, Catherine Fitting, Dirk J. de Jong, João F. Lacerda, António Campos, Willem J. G. Melchers, Katrien Lagrou, Johan Maertens, Thirumala-Devi Kanneganti, Agostinho Carvalho, Oumaima Ibrahim-Granet, Frank L. van de Veerdonk
Published 2018-07-01

A Multidisciplinary Approach to Fungal Infections: One-Year Experiences of a Center of Expertise in Mycology

by Nico A. F. Janssen, Roger J. M. Brüggemann, Monique H. Reijers, Stefanie S. V. Henriet, Jaap ten Oever, Quirijn de Mast, Yvonne Berk, Elizabeth A. de Kort, Bart Jan Kullberg, Mihai G. Netea, Jochem B. Buil, Janette C. Rahamat-Langendoen, Didi Bury, Eline W. Muilwijk, Jacques F. Meis, Paul E. Verweij, Frank L. van de Veerdonk
Published 2020-11-01

Autophagy controls BCG-induced trained immunity and the response to intravesical BCG therapy for bladder cancer.

by Kathrin Buffen, Marije Oosting, Jessica Quintin, Aylwin Ng, Johanneke Kleinnijenhuis, Vinod Kumar, Esther van de Vosse, Cisca Wijmenga, Reinout van Crevel, Egbert Oosterwijk, Anne J Grotenhuis, Sita H Vermeulen, Lambertus A Kiemeney, Frank L van de Veerdonk, Georgios Chamilos, Ramnik J Xavier, Jos W M van der Meer, Mihai G Netea, Leo A B Joosten
Published 2014-10-01

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis

by Rossana G. Iannitti, Valerio Napolioni, Vasilis Oikonomou, Antonella De Luca, Claudia Galosi, Marilena Pariano, Cristina Massi-Benedetti, Monica Borghi, Matteo Puccetti, Vincenzina Lucidi, Carla Colombo, Ersilia Fiscarelli, Cornelia Lass-Flörl, Fabio Majo, Lisa Cariani, Maria Russo, Luigi Porcaro, Gabriella Ricciotti, Helmut Ellemunter, Luigi Ratclif, Fernando Maria De Benedictis, Vincenzo Nicola Talesa, Charles A. Dinarello, Frank L. van de Veerdonk, Luigina Romani
Published 2016-03-01

Increased Plasma Heparanase Activity in COVID-19 Patients

by Baranca Buijsers, Cansu Yanginlar, Aline de Nooijer, Inge Grondman, Marissa L. Maciej-Hulme, Inge Jonkman, Nico A. F. Janssen, Nils Rother, Mark de Graaf, Peter Pickkers, Peter Pickkers, Matthijs Kox, Matthijs Kox, Leo A. B. Joosten, Tom Nijenhuis, Mihai G. Netea, Mihai G. Netea, Luuk Hilbrands, Frank L. van de Veerdonk, Raphaël Duivenvoorden, Raphaël Duivenvoorden, Quirijn de Mast, Johan van der Vlag
Published 2020-10-01

Neuraminidase and SIGLEC15 modulate the host defense against pulmonary aspergillosis

by Intan M.W. Dewi, Cristina Cunha, Martin Jaeger, Mark S. Gresnigt, Marina E. Gkountzinopoulou, Fadel M. Garishah, Cláudio Duarte-Oliveira, Cláudia F. Campos, Lore Vanderbeke, Agustin Resendiz Sharpe, Roger J. Brüggemann, Paul E. Verweij, Katrien Lagrou, Greetje Vande Velde, Quirijn de Mast, Leo A.B. Joosten, Mihai G. Netea, Andre J.A.M. van der Ven, Joost Wauters, Agostinho Carvalho, Frank L. van de Veerdonk
Published 2021-05-01

Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity

by Samuel M. Gonçalves, Cláudio Duarte-Oliveira, Cláudia F. Campos, Vishukumar Aimanianda, Rob ter Horst, Luis Leite, Toine Mercier, Paulo Pereira, Miguel Fernández-García, Daniela Antunes, Cláudia S. Rodrigues, Catarina Barbosa-Matos, Joana Gaifem, Inês Mesquita, António Marques, Nuno S. Osório, Egídio Torrado, Fernando Rodrigues, Sandra Costa, Leo AB. Joosten, Katrien Lagrou, Johan Maertens, João F. Lacerda, António Campos, Gordon D. Brown, Axel A. Brakhage, Coral Barbas, Ricardo Silvestre, Frank L. van de Veerdonk, Georgios Chamilos, Mihai G. Netea, Jean-Paul Latgé, Cristina Cunha, Agostinho Carvalho
Published 2020-05-01