Rag GTPase-mediated regulation of mTORC1 by nutrients is necessary for neonatal autophagy and survival

by Efeyan, Alejo, Zoncu, Roberto, Chang, Steven, Gumper, Iwona, Snitkin, Harriet, Kirak, Oktay, Sabatini, David D., Wolfson, Rachel Laura, Sabatini, David
Published 2015

Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates

by Wyant, Gregory A, Abu-Remaileh, Monther, Sabatini, David M.
Published 2020

Squalene accumulation in cholesterol auxotrophic lymphomas prevents oxidative cell death

by Freinkman, Elizaveta, Chan, Sze Ham, Lewis, Caroline, Sabatini, David M.
Published 2020

The apo-structure of the leucine sensor Sestrin2 is still elusive

by Saxton, Robert Andrew, Knockenhauer, Kevin Edward, Schwartz, Thomas, Sabatini, David
Published 2017

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

by Wang, Tim, Wei, Jenny J., Sabatini, David, Lander, Eric Steven
Published 2015

Absolute Quantification of Matrix Metabolites Reveals the Dynamics of Mitochondrial Metabolism

by Freinkman, Elizaveta, Birsoy, Kıvanç, Chen, Walter W., Wang, Tim, Sabatini, David
Published 2018

Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1

by Comb, William C, Schweitzer, Lawrence David, Bar-Peled, Liron, Sabatini, David
Published 2017

Structure of the human mTOR Complex I and its implications for rapamycin inhibition

by Yip, Calvin K., Murata, Kazuyoshi, Walz, Thomas, Kang, Seong A., Sabatini, David
Published 2012

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening

by Strohecker, A M, Joshi, S, Abraham, R T, White, E, Possemato, Richard, Sabatini, David
Published 2017

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

by Ye, Lan, Varamini, Behzad, Baur, Joseph A., Sabatini, David, Lamming, Dudley W.
Published 2018

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

by Robida-Stubbs, Stacey, Glover-Cutter, Kira, Lamming, Dudley W, Mizunuma, Masaki, Narasimhan, Sri Devi, Neumann-Haefelin, Elke, Sabatini, David M, Blackwell, T. Keith, Lamming, Dudley W., Sabatini, David
Published 2014

Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

by Knockenhauer, Kevin E., Schwartz, Thomas U., Saxton, Robert Andrew, Chantranupong, Lynne, Sabatini, David
Published 2018

Identification of an oncogenic RAB protein

by Wheeler, D. B., Zoncu, R., Root, D. E., Sawyers, C. L., Sabatini, David
Published 2017

Postprandial Hepatic Lipid Metabolism Requires Signaling through Akt2 Independent of the Transcription Factors FoxA2, FoxO1, and SREBP1c

by Wan, Min, Leavens, Karla F, Saleh, Danish, Easton, Rachael M, Guertin, David A., Peterson, Timothy R, Kaestner, Klaus H., Sabatini, David M, Birnbaum, Morris J, Sabatini, David, Peterson, Timothy Richard
Published 2014

A unifying model for mTORC1-mediated regulation of mRNA translation

by Thoreen, Carson C., Chantranupong, Lynne, Wang, Tim, Gray, Nathanael S., Keys, Heather Rochelle, Sabatini, David
Published 2014

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

by Sancak, Yasemin, Bar-Peled, Liron, Zoncu, Roberto, Markhard, Andrew L., Nada, Shigeyuki, Sabatini, David
Published 2012

An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis

by Freinkman, Elizaveta, Wang, Tim, Chen, Walter W., Abu-Remaileh, Monther, Sabatini, David, Birsoy, Kivanc
Published 2017

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

by Chantranupong, Lynne, Orozco, Jose M, Scaria, Sonia M, Bar-Peled, Liron, Spooner, Eric, Isasa, Marta, Gygi, Steven P., Sabatini, David M, Wolfson, Rachel Laura, Saxton, Robert Andrew, Scaria, Sonia M., Sabatini, David
Published 2015

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

by Reiling, Jan H., Clish, Clary, Carette, Jan E., Varadarajan, Malini, Brummelkamp, Thijn R., Sabatini, David
Published 2012

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

by Lamming, Dudley W., Ye, Lan, Astle, Clinton M., Baur, Joseph A., Harrison, David E., Sabatini, David
Published 2015