Structural Basis of Microtubule Destabilization by Potent Auristatin Anti-Mitotics.

by Andrew B Waight, Katja Bargsten, Svetlana Doronina, Michel O Steinmetz, Django Sussman, Andrea E Prota
Published 2016-01-01

Tetrahydroisoquinoline Sulfamates as Potent Microtubule Disruptors: Synthesis, Antiproliferative and Antitubulin Activity of Dichlorobenzyl-Based Derivatives, and a Tubulin Cocryst...

by Wolfgang Dohle, Andrea E. Prota, Grégory Menchon, Ernest Hamel, Michel O. Steinmetz, Barry V. L. Potter
Published 2019-01-01

Abstract OR-8: High-Resolution Structures of Microtubule-Drug Complexes Revealed by Cryo-EM

by Kushal Sejwal, Thorsten B. Blum, Joseph Atherton, Ashwani Sharma, Natacha Olieric, Andrea E. Prota, Carolyn A. Moores, Michel O. Steinmetz
Published 2019-06-01

Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces

by Xiansha Xiao, Joost Willemse, Patrick Voskamp, Xinmeng Li, Andrea E. Prota, Meindert Lamers, Navraj Pannu, Jan Pieter Abrahams, Gilles P. van Wezel
Published 2021-02-01

A fluorescence anisotropy assay to discover and characterize ligands targeting the maytansine site of tubulin

by Grégory Menchon, Andrea E. Prota, Daniel Lucena-Agell, Pascal Bucher, Rolf Jansen, Herbert Irschik, Rolf Müller, Ian Paterson, J. Fernando Díaz, Karl-Heinz Altmann, Michel O. Steinmetz
Published 2018-05-01

Structural Determinants of the Dictyostatin Chemotype for Tubulin Binding Affinity and Antitumor Activity Against Taxane- and Epothilone-Resistant Cancer Cells

by Chiara Trigili, Isabel Barasoain, Pedro A. Sánchez-Murcia, Katja Bargsten, Mariano Redondo-Horcajo, Aurora Nogales, Nicola M. Gardner, Arndt Meyer, Guy J. Naylor, Elena Gómez-Rubio, Federico Gago, Michel O. Steinmetz, Ian Paterson, Andrea E. Prota, J. Fernando Díaz
Published 2016-12-01

Sustainable Syntheses of (−)-Jerantinines A & E and Structural Characterisation of the Jerantinine-Tubulin Complex at the Colchicine Binding Site

by Christopher J. Smedley, Paul A. Stanley, Mohannad E. Qazzaz, Andrea E. Prota, Natacha Olieric, Hilary Collins, Harry Eastman, Andrew S. Barrow, Kuan-Hon Lim, Toh-Seok Kam, Brian J. Smith, Hendrika M. Duivenvoorden, Belinda S. Parker, Tracey D. Bradshaw, Michel O. Steinmetz, John E. Moses
Published 2018-07-01

Crystal Structure of the Cyclostreptin-Tubulin Adduct: Implications for Tubulin Activation by Taxane-Site Ligands

by Francisco de Asís Balaguer, Tobias Mühlethaler, Juan Estévez-Gallego, Enrique Calvo, Juan Francisco Giménez-Abián, April L. Risinger, Erik J. Sorensen, Christopher D. Vanderwal, Karl-Heinz Altmann, Susan L. Mooberry, Michel O. Steinmetz, María Ángela Oliva, Andrea E. Prota, J. Fernando Díaz
Published 2019-03-01

Structural model for differential cap maturation at growing microtubule ends

by Juan Estévez-Gallego, Fernando Josa-Prado, Siou Ku, Ruben M Buey, Francisco A Balaguer, Andrea E Prota, Daniel Lucena-Agell, Christina Kamma-Lorger, Toshiki Yagi, Hiroyuki Iwamoto, Laurence Duchesne, Isabel Barasoain, Michel O Steinmetz, Denis Chrétien, Shinji Kamimura, J Fernando Díaz, Maria A Oliva
Published 2020-03-01

Deconvolution of Buparlisib’s mechanism of action defines specific PI3K and tubulin inhibitors for therapeutic intervention

by Thomas Bohnacker, Andrea E. Prota, Florent Beaufils, John E. Burke, Anna Melone, Alison J. Inglis, Denise Rageot, Alexander M. Sele, Vladimir Cmiljanovic, Natasa Cmiljanovic, Katja Bargsten, Amol Aher, Anna Akhmanova, J. Fernando Díaz, Doriano Fabbro, Marketa Zvelebil, Roger L. Williams, Michel O. Steinmetz, Matthias P. Wymann
Published 2017-03-01

Serial millisecond crystallography for routine room-temperature structure determination at synchrotrons

by Tobias Weinert, Natacha Olieric, Robert Cheng, Steffen Brünle, Daniel James, Dmitry Ozerov, Dardan Gashi, Laura Vera, May Marsh, Kathrin Jaeger, Florian Dworkowski, Ezequiel Panepucci, Shibom Basu, Petr Skopintsev, Andrew S. Doré, Tian Geng, Robert M. Cooke, Mengning Liang, Andrea E. Prota, Valerie Panneels, Przemyslaw Nogly, Ulrich Ermler, Gebhard Schertler, Michael Hennig, Michel O. Steinmetz, Meitian Wang, Jörg Standfuss
Published 2017-09-01