Identification of Functional and Druggable Sites in <i>Aspergillus fumigatus</i> Essential Phosphatases by Virtual Screening

by Benjamin P. Thornton, Anna Johns, Reem Al-Shidhani, Sandra Álvarez-Carretero, Isabelle S. R. Storer, Michael J. Bromley, Lydia Tabernero
Published 2019-09-01

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of <i>Aspergillus fumigatus</i>

by Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E.M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver
Published 2020-04-01

The Aspergillus fumigatus dihydroxyacid dehydratase Ilv3A/IlvC is required for full virulence.

by Jason D Oliver, Sarah J Kaye, Danny Tuckwell, Anna E Johns, Darel A Macdonald, Joanne Livermore, Peter A Warn, Mike Birch, Michael J Bromley
Published 2012-01-01

Aspergillus Fumigatus ZnfA, a Novel Zinc Finger Transcription Factor Involved in Calcium Metabolism and Caspofungin Tolerance

by Clara Valero, Ana Cristina Colabardini, Patrícia Alves de Castro, Lilian Pereira Silva, Laure Nicolas Annick Ries, Lakhansing Pardeshi, Lakhansing Pardeshi, Fang Wang, Fang Wang, Marina Campos Rocha, Iran Malavazi, Roberto Nascimento Silva, Celso Martins, Patrícia Domingos, Cristina Pereira-Silva, Michael J. Bromley, Michael J. Bromley, Koon Ho Wong, Koon Ho Wong, Gustavo H. Goldman
Published 2021-08-01

Correction: Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

by Fabio Gsaller, Peter Hortschansky, Takanori Furukawa, Paul D Carr, Bharat Rash, Javier Capilla, Christoph Müller, Franz Bracher, Paul Bowyer, Hubertus Haas, Axel A Brakhage, Michael J Bromley
Published 2016-12-01

Sterol Biosynthesis and Azole Tolerance Is Governed by the Opposing Actions of SrbA and the CCAAT Binding Complex.

by Fabio Gsaller, Peter Hortschansky, Takanori Furukawa, Paul D Carr, Bharat Rash, Javier Capilla, Christoph Müller, Franz Bracher, Paul Bowyer, Hubertus Haas, Axel A Brakhage, Michael J Bromley
Published 2016-07-01

Determining Aspergillus fumigatus transcription factor expression and function during invasion of the mammalian lung.

by Hong Liu, Wenjie Xu, Vincent M Bruno, Quynh T Phan, Norma V Solis, Carol A Woolford, Rachel L Ehrlich, Amol C Shetty, Carrie McCraken, Jianfeng Lin, Michael J Bromley, Aaron P Mitchell, Scott G Filler
Published 2021-03-01

Filamentous fungal carbon catabolite repression supports metabolic plasticity and stress responses essential for disease progression.

by Sarah R Beattie, Kenneth M K Mark, Arsa Thammahong, Laure Nicolas Annick Ries, Sourabh Dhingra, Alayna K Caffrey-Carr, Chao Cheng, Candice C Black, Paul Bowyer, Michael J Bromley, Joshua J Obar, Gustavo H Goldman, Robert A Cramer
Published 2017-04-01

A Nonredundant Phosphopantetheinyl Transferase, PptA, Is a Novel Antifungal Target That Directs Secondary Metabolite, Siderophore, and Lysine Biosynthesis in Aspergillus fumigatus...

by Anna Johns, Daniel H. Scharf, Fabio Gsaller, Hella Schmidt, Thorsten Heinekamp, Maria Straßburger, Jason D. Oliver, Mike Birch, Nicola Beckmann, Katharine S. Dobb, Jane Gilsenan, Bharatkumar Rash, Elaine Bignell, Axel A. Brakhage, Michael J. Bromley, Jeffrey P. Henderson, Scott J. Hultgren
Published 2017-07-01

The negative cofactor 2 complex is a key regulator of drug resistance in Aspergillus fumigatus

by Takanori Furukawa, Norman van Rhijn, Marcin Fraczek, Fabio Gsaller, Emma Davies, Paul Carr, Sara Gago, Rachael Fortune-Grant, Sayema Rahman, Jane Mabey Gilsenan, Emma Houlder, Caitlin H. Kowalski, Shriya Raj, Sanjoy Paul, Peter Cook, Josie E. Parker, Steve Kelly, Robert A. Cramer, Jean-Paul Latgé, Scott Moye-Rowley, Elaine Bignell, Paul Bowyer, Michael J. Bromley
Published 2020-01-01