mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice

mRNA Encoding a Bispecific Single Domain Antibody Construct Protects against Influenza A Virus Infection in Mice

To date, mRNA-based biologics have mainly been developed for prophylactic and therapeutic vaccination to combat infectious diseases or cancer. In the past years, optimization of the characteristics of in vitro transcribed mRNA has led to significant reduction of the inflammatory responses. Thanks to...

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Bibliographic Details
Main Authors: Lien Van Hoecke, Rein Verbeke, Dorien De Vlieger, Heleen Dewitte, Kenny Roose, Sharon Van Nevel, Olga Krysko, Claus Bachert, Bert Schepens, Ine Lentacker, Xavier Saelens
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
mRNA
mRNA therapeutics
Influeanza A
passive immunization
matrix protein 2
nanoparticles
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120301232

Internet

http://www.sciencedirect.com/science/article/pii/S2162253120301232

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