Mechanism of arginine sensing by CASTOR1 upstream of mTORC1

by Knockenhauer, Kevin E., Schwartz, Thomas U., Saxton, Robert Andrew, Chantranupong, Lynne, Sabatini, David
Published 2018

Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2

by Ye, Lan, Varamini, Behzad, Baur, Joseph A., Sabatini, David, Lamming, Dudley W.
Published 2018

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

by Cervantes, Christopher L., Lim, Daniel Cham-Chin, Kang, Seong A., Pacold, Michael E., Lou, Hua Jane, Ottina, Kathleen, Gray, Nathanael S., Turk, Benjamin E., Yaffe, Michael B, Sabatini, David
Published 2014

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

by Grabiner, Brian C., Nardi, Valentina, Birsoy, Kivanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H., Sabatini, David
Published 2015

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

by Reiling, Jan H., Clish, Clary, Carette, Jan E., Varadarajan, Malini, Brummelkamp, Thijn R., Sabatini, David
Published 2012

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

by Birsoy, Kivanc, Wang, Tim, Possemato, Richard, Koch, Catherine E., Chen, Walter W., Hutchins, Amanda W., Gultekin, Yetis, Carette, Jan E., Brummelkamp, Thijn R., Clish, Clary, Yilmaz, Omer, Peterson, Timothy Richard, Sabatini, David
Published 2013

Rapamycin-Induced Insulin Resistance Is Mediated by mTORC2 Loss and Uncoupled from Longevity

by Lamming, Dudley W., Ye, Lan, Katajisto, Pekka, Goncalves, Marcus D., Saitoh, Maki, Stevens, Deanna M., Davis, James G., Salmon, Adam B., Richardson, Arlan, Ahima, Rexford S., Guertin, David A., Baur, Joseph A., Sabatini, David
Published 2014

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

by Robida-Stubbs, Stacey, Glover-Cutter, Kira, Lamming, Dudley W, Mizunuma, Masaki, Narasimhan, Sri Devi, Neumann-Haefelin, Elke, Sabatini, David M, Blackwell, T. Keith, Lamming, Dudley W., Sabatini, David
Published 2014

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

by Settembre, Carmine, Zoncu, Roberto, Medina, Diego L., Vetrini, Francesco, Erdin, Serkan, Erdin, SerpilUckac, Huynh, Tuong, Ferron, Mathieu, Karsenty, Gerard, Vellard, Michel C., Facchinetti, Valeria, Ballabio, Andrea, Ballabio, Andrea, Sabatini, David
Published 2015

PIK3CA mutant tumors depend on oxoglutarate dehydrogenase

by Ilic, Nina, Birsoy, Kıvanç, Aguirre, Andrew J., Singh, Shambhavi, Moody, Susan E., DeAngelo, Joseph D., Spardy, Nicole A., Freinkman, Elizaveta, Weir, Barbara A., Tsherniak, Aviad, Cowley, Glenn S., Root, David E., Asara, John M., Vazquez, Francisca, Widlund, Hans R., Hahn, William C., Kory, Nora, Sabatini, David, Pacold, Michael Edward
Published 2017

Asymmetric apportioning of aged mitochondria between daughter cells is required for stemness

by Chen, Walter W., Marjanovic, Nemanja, Zoncu, Roberto, Katajisto, Pekka, Dohla, Julia, Chaffer, Christine L., Pentinmikko, Nalle, Iqbal, Sharif, Weinberg, Robert A, Sabatini, David
Published 2015

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake

by Katajisto, Pekka, Lamming, Dudley W., Gultekin, Yetis, Bauer-Rowe, Khristian E., Sengupta, Shomit, Birsoy, Kivanc, Dursun, Abdulmetin, Yilmaz, V. Onur, Selig, Martin, Nielson, G. Petur, Mino-Kenudson, Mari, Zuckerberg, Lawrence, Bahn, Atul K., Deshpande, Vikram, Yilmaz, Omer, Sabatini, David
Published 2012

Young and old genetically heterogeneous HET3 mice on a rapamycin diet are glucose intolerant but insulin sensitive

by Lamming, Dudley W., Ye, Lan, Astle, Clinton M., Baur, Joseph A., Harrison, David E., Sabatini, David
Published 2015

Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes

by Fonslow, Bryan R., Kang, Seong A., Gestaut, Daniel R., Graczyk, Beth, Davis, Trisha N., Yates III, John R., Sabatini, David
Published 2012

MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma

by Wood, Kris C., Konieczkowski, David J., Johannessen, Cory M., Boehm, Jesse S., Tamayo, Pablo, Botvinnik, Olga B., Mesirov, Jill P., Hahn, William C., Root, David E., Garraway, Levi A., Sabatini, David
Published 2014

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

by Martz, C. A., Ottina, Kathleen, Singleton, K. R., Jasper, J. S., Wardell, S. E., Peraza-Penton, A., Anderson, G. R., Winter, P. S., Alley, H. M., Kwong, L. N., Cooper, Z. A., Tetzlaff, M., Chen, P.-L, Rathmell, J. C., Flaherty, K. T., Wargo, J. A., McDonnell, D. P., Wood, K. C., Wang, Tim, Sabatini, David
Published 2015

Rictor Phosphorylation on the THR-1135 Site Does Not Require Mammalian Target of Rapamycin Complex 2

by Boulbes, Delphine, Chen, Chien-Hung, Shaikenov, Tattym, Agarwal, Nitin K., Addona, Terri A., Keshishian, Hasmik, Carr, Steven A., Magnuson, Mark A., Sarbassov, Dos D., Sabatini, David, Peterson, Timothy Richard
Published 2012

Metabolic determinants of cancer cell sensitivity to glucose limitation and biguanides

by Possemato, Richard, Lorbeer, Franziska K., Bayraktar, Erol C., Thiru, Prathapan, Yucel, Burcu, Wang, Tim, Chen, Walter W., Clish, Clary, Wang, Tim, Birsoy, Kivanc, Sabatini, David
Published 2015

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

by Kang, Seong A., Cervantes, Christopher L., Lim, Daniel Cham-Chin, Ottina, Kathleen, Lou, Hua Jane, Gray, Nathanael S., Turk, Benjamin E., Pacold, Michael Edward, Yaffe, Michael B, Sabatini, David
Published 2014

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

by Rohde, Jason M., Brimacombe, Kyle R., Liu, Li, Pacold, Michael Edward, Yasgar, Adam, Cheff, Dorian M., Lee, Tobie D., Rai, Ganesha, Baljinnyam, Bolormaa, Li, Zhuyin, Simeonov, Anton, Hall, Matthew D., Shen, Min, Sabatini, David, Boxer, Matthew B.
Published 2020