Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

by Klein, Isaac A., Sabari, Benjamin R., Dall'Agnese, Alessandra, Coffey, Eliot L., Zamudio, Alicia V., Manteiga, John C., Hannett, Nancy M., Abraham, Brian J., Afeyan, Lena K., Guo, Yang E., Schuijers, Jurian, Lee, Tong Ihn, Taatjes, Dylan J., Young, Richard A., Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology, Li, Charles H.
Published 2020

Single-cell RNA-seq reveals dynamic paracrine control of cellular variation

by Satija, Rahul, Shuga, Joe, Trombetta, John J., Gennert, David, Chen, Peilin, Gertner, Rona S., Gaublomme, Jellert T., Yosef, Nir, Schwartz, Schraga, Fowler, Brian, Weaver, Suzanne, Wang, Jing, Wang, Xiaohui, Ding, Ruihua, Raychowdhury, Raktima, Friedman, Nir, Hacohen, Nir, Park, Hongkun, May, Andrew P., Regev, Aviv, Shalek, Alex K., Lu, Diana, Ph. D. Massachusetts Institute of Technology
Published 2015

Bacterial infection remodels the DNA methylation landscape of human dendritic cells

by Pacis, Alain, Tailleux, Ludovic, Morin, Alexander M., Lambourne, John, MacIsaac, Julia L., Yotova, Vania, Dumaine, Anne, Danckaert, Anne, Luca, Francesca, Grenier, Jean-Christophe, Hansen, Kasper D., Gicquel, Brigitte, He, Chuan, Tung, Jenny, Pastinen, Tomi, Kobor, Michael S., Pique-Regi, Roger, Gilad, Yoav, Barreiro, Luis B., Pai, Athma A., Yu, Miao, Ph. D. Massachusetts Institute of Technology
Published 2016

Genetic engineering of human ES and iPS cells using TALE nucleases

by Hockemeyer, Dirk, Wang, Haoyi, Kiani, Samira, Lai, Christine S., Gao, Qing, Cassady, John P., Cost, Gregory J., Santiago, Yolanda, Miller, Jeffrey C., Zeitler, Bryan, Cherone, Jennifer Michelle, Meng, Xiangdong, Hinkley, Sarah J., Rebar, Edward J., Gregory, Philip D., Urnov, Fyodor D., Jaenisch, Rudolf, Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014
Published 2012

Generation of Isogenic Pluripotent Stem Cells Differing Exclusively at Two Early Onset Parkinson Point Mutations

by Soldner, Frank, Hockemeyer, Dirk, Gao, Qing, Alagappan, Raaji, Khurana, Vikram, Golbe, Lawrence I, Myers, Richard H., Lindquist, Susan, Guschin, Dmitry, Fong, Lauren K, Vu, B. Joseph, Meng, Xiangdong, Urnov, Fyodor D, Rebar, Edward J, Gregory, Philip D., Zhang, H. Steve, Jaenisch, Rudolf, Laganiere, Josee, Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014, Cheng, Albert Wu
Published 2014

A vector-free microfluidic platform for intracellular delivery

by Sharei, Armon Reza, Zoldan, Janeta, Sim, Woo Young, Cho, Nahyun, Jackson, Emily L., Mao, Shirley, Schneider, Sabine, Kim, Kwang-Soo, Han, Min-Joon, Lytton-Jean, Abigail K. R., Basto, Pamela Antonia, Jhunjhunwala, Siddharth, Heller, Daniel A., Kang, Jeon Woong, Hartoularos, George C., Anderson, Daniel Griffith, Langer, Robert, Jensen, Klavs F., Adamo, Andrea 1975-, Lee, Jungmin, Ph. D. Massachusetts Institute of Technology
Published 2013

Purine synthesis promotes maintenance of brain tumor initiating cells in glioma

by Wang, Xiuxing, Yang, Kailin, Xie, Qi, Wu, Qiulian, Mack, Stephen C, Kim, Leo J Y, Prager, Briana C, Flavahan, William A, Liu, Xiaojing, Singer, Meromit, Hubert, Christopher G, Miller, Tyler E, Zhou, Wenchao, Huang, Zhi, Fang, Xiaoguang, Suvà, Mario L, Hwang, Tae Hyun, Locasale, Jason W, Bao, Shideng, Rich, Jeremy N, Regev, Aviv, Shi, Yu, Ph. D. Massachusetts Institute of Technology
Published 2018

TET1 plays an essential oncogenic role in MLL-rearranged leukemia

by Jaenisch, Rudolf, Huang, Hao, Jiang, Xi, Li, Zejuan, Li, Yuanyuan, Song, Chun-Xiao, He, Chunjiang, Chen, Ping, Gurbuxani, Sandeep, Wang, Jiapeng, Hong, Gia-Ming, Elkahloun, Abdel G., Arnovitz, Stephen, Wang, Jinhua, Szulwach, Keith, Lin, Li, Street, Craig, Wunderlich, Mark, Dawlaty, Meelad M., Neilly, Mary Beth, Yang, Feng-Chun, Mulloy, James C., Jin, Peng, Liu, Paul P., Rowley, Janet D., Xu, Mingjiang, He, Chuan, Chen, Jianjun, Sun, Miao, M. Eng. Massachusetts Institute of Technology
Published 2014

Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis

by Sayin, Volkan I., Singh, Simranjit X., LeBoeuf, Sarah E., Karakousi, Triantafyllia R., Martinez, Britney, Bronson, Roderick T., Prigge, Justin R., Schmidt, Edward E., Thomas, Craig J., Goparaju, Chandra, Davies, Angela, Dolgalev, Igor, Heguy, Adriana, Allaj, Viola, Poirier, John T., Moreira, Andre L., Rudin, Charles M., Pass, Harvey I., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Ellis, Donald Christian, Bhutkar, Arjun, Sanchez-Rivera, Francisco Javier, Subbaraj, Lakshmipriya, Vander Heiden, Matthew G., Jacks, Tyler E., Romero, Rodrigo,Ph. D.Massachusetts Institute of Technology
Published 2018

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

by DeKelver, Russell C., Choi, Vivian M., Moehle, Erica A., Paschon, David E., Hockemeyer, Dirk, Meijsing, Sebastiaan H., Sancak, Yasemin, Cui, Xiaoxia, Steine, Eveline J., Miller, Jeffrey C., Tam, Phillip, Bartsevich, Victor V., Meng, Xiangdong, Rupniewski, Igor, Gopalan, Sunita M., Sun, Helena C., Pitz, Kathleen J., Rock, Jeremy M., Davis, Gregory D., Rebar, Edward J., Yamamoto, Keith R., Jaenisch, Rudolf, Gregory, Philip D., Urnov, Fyodor D., Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014, Cheeseman, Iain M, Sabatini, David
Published 2012

Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

by Jason, Flannick, Fuchsberger, Christian, Mahajan, Anubha, Teslovich, Tanya M., Agarwala, Vineeta, Gaulton, Kyle J., Caulkins, Lizz, Koesterer, Ryan, Ma, Clement, Moutsianas, Loukas, McCarthy, Davis J., Rivas, Manuel A., Perry, John R. B., Sim, Xueling, Blackwell, Thomas W., Robertson, Neil R., Rayner, N William, Cingolani, Pablo, Locke, Adam E., Tajes, Juan Fernandez, Highland, Heather M., Dupuis, Josee, Chines, Peter S., Lindgren, Cecilia M., Hartl, Christopher, Jackson, Anne U., Chen, Han, Huyghe, Jeroen R., van de Bunt, Martijn, Pearson, Richard D., Kumar, Ashish, Müller-Nurasyid, Martina, Grarup, Niels, Stringham, Heather M., Gamazon, Eric R., Chen, Yuhui, Scott, Robert A., Below, Jennifer E., Chen, Peng, Huang, Jinyan, Go, Min Jin, Stitzel, Michael L., Pasko, Dorota, Parker, Stephen C. J., Varga, Tibor V., Green, Todd, Beer, Nicola L., Day-Williams, Aaron G., Ferreira, Teresa, Fingerlin, Tasha, Horikoshi, Momoko, Hu, Cheng, Huh, Iksoo, Ikram, Mohammad Kamran, Kim, Bong-Jo, Kim, Yongkang, Kim, Young Jin, Kwon, Min-Seok, Lee, Juyoung, Lee, Selyeong, Lin, Keng-Han, Maxwell, Taylor J., Nagai, Yoshihiko, Wang, Xu, Welch, Ryan P., Yoon, Joon, Zhang, Weihua, Barzilai, Nir, Voight, Benjamin F., Han, Bok-Ghee, Jenkinson, Christopher P., Kuulasmaa, Teemu, Kuusisto, Johanna, Manning, Alisa, Ng, Maggie C. Y., Palmer, Nicholette D., Balkau, Beverley, Stančáková, Alena, Abboud, Hanna E., Boeing, Heiner, Giedraitis, Vilmantas, Prabhakaran, Dorairaj, Gottesman, Omri, Scott, James, Carey, Jason, Kwan, Phoenix, Grant, George, Smith, Joshua D., Neale, Benjamin M., Purcell, Shaun, Butterworth, Adam S., Howson, Joanna M. M., Lee, Heung Man, Lu, Yingchang, Kwak, Soo-Heon, Zhao, Wei, Danesh, John, Lam, Vincent K. L., Park, Kyong Soo, Saleheen, Danish, So, Wing Yee, Tam, Claudia H. T., Afzal, Uzma, Aguilar, David, Arya, Rector, Aung, Tin, Chan, Edmund, Navarro, Carmen, Cheng, Ching-Yu, Palli, Domenico, Correa, Adolfo, Curran, Joanne E., Rybin, Dennis, Farook, Vidya S., Fowler, Sharon P., Freedman, Barry I., Griswold, Michael, Hale, Daniel Esten, Hicks, Pamela J., Khor, Chiea-Chuen, Kumar, Satish, Lehne, Benjamin, Thuillier, Dorothée, Lim, Wei Yen, Liu, Jianjun, Loh, Marie, Musani, Solomon K., Puppala, Sobha, Scott, William R., Yengo, Loïc, Tan, Sian-Tsung, Taylor, Herman A., Thameem, Farook, Wilson, Gregory, Wong, Tien Yin, Njølstad, Pål Rasmus, Levy, Jonathan C., Mangino, Massimo, Bonnycastle, Lori L., Schwarzmayr, Thomas, Fadista, João, Surdulescu, Gabriela L., Herder, Christian, Groves, Christopher J., Wieland, Thomas, Bork-Jensen, Jette, Brandslund, Ivan, Christensen, Cramer, Koistinen, Heikki A., Doney, Alex S. F., Kinnunen, Leena, Esko, Tõnu, Farmer, Andrew J., Hakaste, Liisa, Hodgkiss, Dylan, Kravic, Jasmina, Lyssenko, Valeri, Hollensted, Mette, Jørgensen, Marit E., Jørgensen, Torben, Ladenvall, Claes, Justesen, Johanne Marie, Käräjämäki, Annemari, Kriebel, Jennifer, Rathmann, Wolfgang, Lannfelt, Lars, Lauritzen, Torsten, Narisu, Narisu, Linneberg, Allan, Melander, Olle, Milani, Lili, Neville, Matt, Orho-Melander, Marju, Qi, Lu, Qi, Qibin, Roden, Michael, Rolandsson, Olov, Altshuler, David, Lee, Jaehoon, Ph. D. Massachusetts Institute of Technology
Published 2018

Comprehensive Molecular Characterization of Pheochromocytoma and Paraganglioma

by Fishbein, Lauren, Walter, Vonn, Danilova, Ludmila, Robertson, A. Gordon, Johnson, Amy R., Lichtenberg, Tara M., Murray, Bradley A., Ghayee, Hans K., Else, Tobias, Ling, Shiyun, Jefferys, Stuart R., de Cubas, Aguirre A., Wenz, Brandon, Korpershoek, Esther, Amelio, Antonio L., Makowski, Liza, Rathmell, W. Kimryn, Gimenez-Roqueplo, Giordano, Thomas J., Asa, Sylvia L., Tischler, Arthur S., Pacak, Karel, Nathanson, Katherine L., Wilkerson, Matthew D., Akbani, Rehan, Ally, Adrian, Amar, Laurence, Amelio, Antonio L., Arachchi, Harindra, Asa, Sylvia L., Auchus, Richard J., Auman, J. Todd, Baertsch, Robert, Balasundaram, Miruna, Balu, Saianand, Bartsch, Detlef K., Baudin, Eric, Bauer, Thomas, Beaver, Allison, Benz, Christopher, Beroukhim, Rameen, Beuschlein, Felix, Bodenheimer, Tom, Boice, Lori, Bowlby, Reanne, Brooks, Denise, Carlsen, Rebecca, Carter, Suzie, Cassol, Clarissa A., Cherniack, Andrew D., Chin, Lynda, Cho, Juok, Chuah, Eric, Chudamani, Sudha, Cope, Leslie, Crain, Daniel, Curley, Erin, Danilova, Ludmila, de Cubas, Aguirre A., de Krijger, Ronald R., Demchok, John A., Deutschbein, Timo, Dhalla, Noreen, Dimmock, David, Dinjens, Winand N.M, Else, Tobias, Eng, Charis, Eschbacher, Jennifer, Fassnacht, Martin, Felau, Ina, Feldman, Michael, Ferguson, Martin L., Fiddes, Ian, Fishbein, Lauren, Frazer, Scott, Gabriel, Stacey B., Gardner, Johanna, Gastier-Foster, Julie M., Gehlenborg, Nils, Gerken, Mark, Getz, Gad, Geurts, Jennifer, Ghayee, Hans K., Gimenez-Roqueplo, Giordano, Thomas J., Goldman, Mary, Graim, Kiley, Gupta, Manaswi, Haan, David, Hahner, Stefanie, Hantel, Constanze, Haussler, David, Hayes, D. Neil, Heiman, David I., Hoadley, Katherine A., Holt, Robert A., Hoyle, Alan P., Huang, Mei, Hunt, Bryan, Hutter, Carolyn M., Jefferys, Stuart R., Johnson, Amy R., Jones, Steven J.M, Jones, Corbin D., Kasaian, Katayoon, Kebebew, Electron, Kim, Jaegil, Kimes, Patrick, Knijnenburg, Theo, Korpershoek, Esther, Lander, Eric, Lawrence, Michael S., Lechan, Ronald, Lee, Darlene, Leraas, Kristen M., Lerario, Antonio, Lichtenberg, Tara M., Lin, Pei, Ling, Shiyun, Liu, Jia, LiVolsi, Virginia A., Lolla, Laxmi, Lotan, Yair, Lu, Yiling, Ma, Yussanne, Maison, Nicole, Makowski, Liza, Mallery, David, Mannelli, Massimo, Marquard, Jessica, Marra, Marco A., Matthew, Thomas, Mayo, Michael, Méatchi, Tchao, Meng, Shaowu, Merino, Maria J., Mete, Ozgur, Meyerson, Matthew, Mieczkowski, Piotr A., Mills, Gordon B., Moore, Richard A., Morozova, Olena, Morris, Scott, Mose, Lisle E., Mungall, Andrew J., Murray, Bradley A., Naresh, Rashi, Nathanson, Katherine L., Newton, Yulia, Ng, Sam, Ni, Ying, Noble, Michael S., Nwariaku, Fiemu, Pacak, Karel, Parker, Joel S., Paul, Evan, Penny, Robert, Perou, Charles M., Perou, Amy H., Pihl, Todd, Powers, James, Rabaglia, Jennifer, Radenbaugh, Amie, Ramirez, Nilsa C., Rao, Arjun, Rathmell, W. Kimryn, Riester, Anna, Roach, Jeffrey, Robertson, A. Gordon, Sadeghi, Sara, Saksena, Gordon, Salama, Sofie, Saller, Charles, Sandusky, George, Sbiera, Silviu, Schein, Jacqueline E., Schumacher, Steven E., Shelton, Candace, Shelton, Troy, Sheth, Margi, Shi, Yan, Shih, Juliann, Shmulevich, Ilya, Simons, Janae V., Sipahimalani, Payal, Skelly, Tara, Sofia, Heidi J., Sokolov, Artem, Soloway, Matthew G., Sougnez, Carrie, Stuart, Josh, Sun, Charlie, Swatloski, Teresa, Tam, Angela, Tan, Donghui, Tarnuzzer, Roy, Tarvin, Katherine, Thiessen, Nina, Thorne, Leigh B., Timmers, Henri J., Tischler, Arthur S., Tse, Kane, Uzunangelov, Vlado, van Berkel, Anouk, Veluvolu, Umadevi, Vicha, Ales, Voet, Doug, Waldmann, Jens, Walter, Vonn, Wan, Yunhu, Wang, Zhining, Wang, Tracy S., Weaver, Joellen, Weinstein, John N., Weismann, Dirk, Wenz, Brandon, Wilkerson, Matthew D., Wise, Lisa, Wong, Tina, Wu, Ye, Yang, Liming, Zelinka, Tomas, Zenklusen, Jean C., Zhang, Jiashan (Julia), Zhang, Wei, Zhu, Jingchun, Zinzindohoué, Franck, Zmuda, Erik, Leshchiner, Ignaty, Lander, Eric Steven, Wong, Christopher, M. Eng. Massachusetts Institute of Technology
Published 2018

Genomically encoded analog memory with precise in vivo DNA writing in living cell populations

by Farzadfard, Fahim, Lu, Timothy K
Published 2016

A novel k-mer set memory (KSM) motif representation improves regulatory variant prediction

by Guo, Yuchun, Tian, Kevin J., Zeng, Haoyang, Guo, Xiaoyun, Gifford, David K
Published 2018

Image-guided neural activity manipulation with a paramagnetic drug

by Bricault, Sarah Jean, Barandov, Ali, Harvey, Peter, DeTienne, Elizabeth, Hai, Aviad, Jasanoff, Alan Pradip
Published 2020

The Design, Fabrication, and Performance of the East African Trial Leveraged Freedom Chair

by Pearlman, Jonathan L., Winter, Amos G., Bollini, Mario A, DeLatte, Danielle M, Judge, Benjamin M, O'Hanley, Harrison F, Scolnik, Natasha
Published 2017

Metagenomic mining of regulatory elements enables programmable species-selective gene expression

by Johns, Nathan I, Yim, Sung Sun, Blazejewski, Tomasz, Dias Gomes, Antonio, Yang, Anthony, Smillie, Chris S, Smith, Mark Burnham, Alm, Eric J, Kosuri, Sriram, Wang, Harris H
Published 2018

Bacteriophage-based synthetic biology for the study of infectious diseases

by Citorik, Robert James, Mimee, Mark Kyle, Lu, Timothy K
Published 2014

The Initial Response to the Boston Marathon Bombing

by Gates, Jonathan D., Arabian, Sandra, Biddinger, Paul, Blansfield, Joe, Burke, Peter, Chung, Sarita, Friedman, Franklin, Gervasini, Alice, Goralnick, Eric, Gupta, Alok, Larentzakis, Andreas, McMahon, Maria, Mella, Juan, Michaud, Yvonne, Rabinovici, Reuven, Sweet, Darlene, Ulrich, Andrew, Velmahos, George, Weber, Cheryl, Fischer, Jonathan D, Yaffe, Michael B
Published 2018

Evolving concepts of specificity in immune reactions

by Chakraborty, Arup K, Eisen, Herman N.
Published 2017