mTORC1 Activates SREBP-1c and Uncouples Lipogenesis From Gluconeogenesis

by Laplante, Mathieu, Sabatini, David
Published 2011

Growth signaling at the nexus of stem cell life and death

by Wood, Kris C., Sabatini, David
Published 2009

Native capillary isoelectric focusing for the separation of protein complex isoforms and subcomplexes

by Fonslow, Bryan R., Kang, Seong A., Gestaut, Daniel R., Graczyk, Beth, Davis, Trisha N., Yates III, John R., Sabatini, David
Published 2012

MicroSCALE Screening Reveals Genetic Modifiers of Therapeutic Response in Melanoma

by Wood, Kris C., Konieczkowski, David J., Johannessen, Cory M., Boehm, Jesse S., Tamayo, Pablo, Botvinnik, Olga B., Mesirov, Jill P., Hahn, William C., Root, David E., Garraway, Levi A., Sabatini, David
Published 2014

Activating mTOR Mutations in a Patient with an Extraordinary Response on a Phase I Trial of Everolimus and Pazopanib

by Wagle, N., Grabiner, Brian C., Van Allen, E. M., Hodis, Eran, Jacobus, S., Supko, J. G., Stewart, M., Choueiri, T. K., Gandhi, L., Cleary, J. M., Elfiky, A. A., Taplin, M. E., Stack, E. C., Signoretti, S., Loda, Massimo, Shapiro, G. I., Gabriel, Stacey B., Kantoff, Philip W., Garraway, Levi A., Rosenberg, J. E., Sabatini, David, Lander, Eric Steven
Published 2015

Systematic identification of signaling pathways with potential to confer anticancer drug resistance

by Martz, C. A., Ottina, Kathleen, Singleton, K. R., Jasper, J. S., Wardell, S. E., Peraza-Penton, A., Anderson, G. R., Winter, P. S., Alley, H. M., Kwong, L. N., Cooper, Z. A., Tetzlaff, M., Chen, P.-L, Rathmell, J. C., Flaherty, K. T., Wargo, J. A., McDonnell, D. P., Wood, K. C., Wang, Tim, Sabatini, David
Published 2015

Rapamycin inhibits mTORC1, but not completely

by Thoreen, Carson C, Sabatini, David
Published 2012

mTOR: from growth signal integration to cancer, diabetes and ageing

by Zoncu, Roberto, Efeyan, Alejo, Sabatini, David
Published 2012

Structure of the human mTOR Complex I and its implications for rapamycin inhibition

by Yip, Calvin K., Murata, Kazuyoshi, Walz, Thomas, Kang, Seong A., Sabatini, David
Published 2012

A unifying model for mTORC1-mediated regulation of mRNA translation

by Thoreen, Carson C., Chantranupong, Lynne, Wang, Tim, Gray, Nathanael S., Keys, Heather Rochelle, Sabatini, David
Published 2014

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

by Liu, Qingsong, Xu, Chunxiao, Kirubakaran, Sivapriya, Zhang, Xin, Hur, Wooyoung, Kwiatkowski, Nicholas P., Wang, Jinhua, Westover, Kenneth D., Gao, Peng, Ercan, Dalia, Niepel, Mario, Thoreen, Carson C., Kang, Seong A., Patricelli, Matthew P., Wang, Yuchuan, Tupper, Tanya, Altabef, Abigail, Kawamura, Hidemasa, Held, Kathryn D., Chou, Danny M., Elledge, Stephen J., Janne, Pasi A., Wong, Kwok-Kin, Gray, Nathanael S., Sabatini, David, Liu, Yan
Published 2015

Selective ATP-Competitive Inhibitors of TOR Suppress Rapamycin-Insensitive Function of TORC2 in S. cerevisiae

by Liu, Qingsong, Ren, Tao, Fresques, Tara, Oppliger, Wolfgang, Niles, Brad J., Hur, Wooyoung, Hall, Michael N., Powers, Ted, Gray, Nathanael S., Sabatini, David
Published 2015

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

by Grabiner, Brian C., Nardi, Valentina, Birsoy, Kivanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H., Sabatini, David
Published 2015

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapa...

by Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew L., Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Gray, Nathanael S., Sabatini, David
Published 2014

Cancer Cell Metabolism: One Hallmark, Many Faces

by Cantor, Jason R., Sabatini, David
Published 2015

Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome

by DeKelver, Russell C., Choi, Vivian M., Moehle, Erica A., Paschon, David E., Hockemeyer, Dirk, Meijsing, Sebastiaan H., Sancak, Yasemin, Cui, Xiaoxia, Steine, Eveline J., Miller, Jeffrey C., Tam, Phillip, Bartsevich, Victor V., Meng, Xiangdong, Rupniewski, Igor, Gopalan, Sunita M., Sun, Helena C., Pitz, Kathleen J., Rock, Jeremy M., Davis, Gregory D., Rebar, Edward J., Yamamoto, Keith R., Jaenisch, Rudolf, Gregory, Philip D., Urnov, Fyodor D., Zhang, Lei, Ph. D Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, fl. 2014, Cheeseman, Iain M, Sabatini, David
Published 2012

MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors

by Birsoy, Kivanc, Wang, Tim, Possemato, Richard, Koch, Catherine E., Chen, Walter W., Hutchins, Amanda W., Gultekin, Yetis, Carette, Jan E., Brummelkamp, Thijn R., Clish, Clary, Yilmaz, Omer, Peterson, Timothy Richard, Sabatini, David
Published 2013

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

by Settembre, Carmine, Zoncu, Roberto, Medina, Diego L., Vetrini, Francesco, Erdin, Serkan, Erdin, SerpilUckac, Huynh, Tuong, Ferron, Mathieu, Karsenty, Gerard, Vellard, Michel C., Facchinetti, Valeria, Ballabio, Andrea, Ballabio, Andrea, Sabatini, David
Published 2015

mTOR and cancer: many loops in one pathway

by Efeyan, Alejo, Sabatini, David
Published 2012

The TASCC of Secretion

by Zoncu, Roberto, Sabatini, David
Published 2013