Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies

by Chao Peng, Ronald J. Gathagan, Virginia M.-Y. Lee
Published 2018-01-01

Alzheimer’s disease tau is a prominent pathology in LRRK2 Parkinson’s disease

by Michael X. Henderson, Medha Sengupta, John Q. Trojanowski, Virginia M. Y. Lee
Published 2019-11-01

LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons

by Michael X. Henderson, Chao Peng, John Q. Trojanowski, Virginia M. Y. Lee
Published 2018-05-01

Brain Microvascular Pericytes in Vascular Cognitive Impairment and Dementia

by Maiko T. Uemura, Maiko T. Uemura, Takakuni Maki, Masafumi Ihara, Virginia M. Y. Lee, John Q. Trojanowski
Published 2020-04-01

Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs

by Kurt R. Brunden, Virginia M-Y. Lee, Amos B. Smith, III, John Q. Trojanowski, Carlo Ballatore
Published 2017-09-01

Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members.

by Andrew W Hwang, Hanna Trzeciakiewicz, Dave Friedmann, Chao-Xing Yuan, Ronen Marmorstein, Virginia M Y Lee, Todd J Cohen
Published 2016-01-01

eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS

by Lindsey D. Goodman, Mercedes Prudencio, Ananth R. Srinivasan, Olivia M. Rifai, Virginia M.-Y. Lee, Leonard Petrucelli, Nancy M. Bonini
Published 2019-04-01

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration

by Hien T. Tran, Charlotte Hiu-Yan Chung, Michiyo Iba, Bin Zhang, John Q. Trojanowski, Kelvin C. Luk, Virginia M.Y. Lee
Published 2014-06-01

Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis.

by Johannes Brettschneider, Jon B Toledo, Vivianna M Van Deerlin, Lauren Elman, Leo McCluskey, Virginia M-Y Lee, John Q Trojanowski
Published 2012-01-01

LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice

by Michael X. Henderson, Medha Sengupta, Ian McGeary, Bin Zhang, Modupe F. Olufemi, Hannah Brown, John Q. Trojanowski, Virginia M. Y. Lee
Published 2019-02-01

Detection of Alzheimer’s disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau)...

by Garrett S. Gibbons, Soo-Jung Kim, John L. Robinson, Lakshmi Changolkar, David J. Irwin, Leslie M. Shaw, Virginia M.-Y. Lee, John Q. Trojanowski
Published 2019-03-01

Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies

by Amit Berson, Lindsey D. Goodman, Ashley N. Sartoris, Charlton G. Otte, James A. Aykit, Virginia M.-Y. Lee, John Q. Trojanowski, Nancy M. Bonini
Published 2019-04-01

Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain

by Gabor G. Kovacs, Sharon X. Xie, John L. Robinson, Edward B. Lee, Douglas H. Smith, Theresa Schuck, Virginia M.-Y. Lee, John Q. Trojanowski
Published 2018-06-01

Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo

by Sílvia Porta, Yan Xu, Clark R. Restrepo, Linda K. Kwong, Bin Zhang, Hannah J. Brown, Edward B. Lee, John Q. Trojanowski, Virginia M.-Y. Lee
Published 2018-10-01

P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating.

by Hiroki Takeuchi, Michiyo Iba, Haruhisa Inoue, Makoto Higuchi, Keizo Takao, Kayoko Tsukita, Yoshiko Karatsu, Yumiko Iwamoto, Tsuyoshi Miyakawa, Tetsuya Suhara, John Q Trojanowski, Virginia M-Y Lee, Ryosuke Takahashi
Published 2011-01-01

A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model

by Bin Zhang, Yuemang Yao, Anne-Sophie Cornec, Killian Oukoloff, Michael J. James, Pyry Koivula, John Q. Trojanowski, Amos B. Smith, Virginia M.-Y. Lee, Carlo Ballatore, Kurt R. Brunden
Published 2018-11-01

Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

by Kelvin C. Luk, Dustin J. Covell, Victoria M. Kehm, Bin Zhang, Insung Y. Song, Matthew D. Byrne, Rose M. Pitkin, Samantha C. Decker, John Q. Trojanowski, Virginia M.-Y. Lee
Published 2016-09-01

Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples

by Laura N. Puentes, Zsofia Lengyel-Zhand, Ji Youn Lee, Chia-Ju Hsieh, Mark E. Schneider, Kimberly J. Edwards, Kelvin C. Luk, Virginia M.-Y. Lee, John Q. Trojanowski, Robert H. Mach
Published 2021-06-01

Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery

by Mandana Hunter, Krista J. Spiller, Myrna A. Dominique, Hong Xu, Francis W. Hunter, Terry C. Fang, Rebecca G. Canter, Christopher J. Roberts, Richard M. Ransohoff, John Q. Trojanowski, Virginia M.-Y. Lee
Published 2021-08-01

Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice

by Krista J. Spiller, Tahiyana Khan, Myrna A. Dominique, Clark R. Restrepo, Dejania Cotton-Samuel, Maya Levitan, Paymaan Jafar-Nejad, Bin Zhang, Armand Soriano, Frank Rigo, John Q. Trojanowski, Virginia M.-Y. Lee
Published 2019-04-01