mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H+-ATPase

by Zoncu, Roberto, Bar-Peled, Liron, Efeyan, Alejo, Sancak, Yasemin, Sabatini, David M., Wang, Shuyu, Ph. D. Massachusetts Institute of Technology
Published 2015

Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers

by Eisen, Ellen A., Eisen, Herman N., Kang, Myung Sun, Eisen, Timothy Jonas, Chakraborty, Arup K
Published 2015

Longitudinal multiparameter assay of lymphocyte interactions from onset by microfluidic cell pairing and culture

by Servos, Mariah M., Dougan, Stephanie K., Dura, Burak, Barry, Rachel M, Ploegh, Hidde, Voldman, Joel
Published 2016

Transcriptional profiling of cells sorted by transcript abundance

by Klemm, Sandy Lee, Semrau, Stefan, Wiebrands, Kay, Mooijman, Dylan, Jaenisch, Rudolf, van Oudenaarden, Alexander, Faddah, Dina A.
Published 2015

Cooperative nutrient accumulation sustains growth of mammalian cells

by Son, Sungmin, Stevens, Mark M., Chao, Hui Xiao, Weng, Yaochung, Wood, Kris, Vander Heiden, Matthew G., Hosios, Aaron Marc, Schweitzer, Lawrence David, Thoreen, Carson C, Sabatini, David, Manalis, Scott R
Published 2016

A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth

by Meacham, Corbin Elizabeth, Lawton, Lee N., Pritchard, Justin R., Ehrenberger, Tobias, Fenouille, Nina, Zuber, Johannes, Williams, Richard T., Young, Richard A., Soto Feliciano, Yadira Marie, Hemann, Michael, Joughin, Brian Alan
Published 2015

Durable antitumor responses to CD47 blockade require adaptive immune stimulation

by Sockolosky, Jonathan T., Ho, Chia Chi M., Almo, Steven C., Garcia, K. Christopher, Dougan, Michael, Kauke, Monique Jacqueline, Ploegh, Hidde, Ingram, Jessica R.
Published 2016

Excess cholesterol induces mouse egg activation and may cause female infertility

by Yesilaltay, Ayce, Dokshin, Gregoriy A., Busso, Dolores, Wang, Li, Galiani, Dalia, Vasile, Eliza, Quilaqueo, Linda, Orellana, Juan Andrés, Shalgi, Ruth, Dekel, Nava, Albertini, David F., Rigotti, Attilio, Krieger, Monty, Walzer, Dalia F., Page, David C, Chavarria, Tony E
Published 2015

Dihydropyrimidine Accumulation Is Required for the Epithelial-Mesenchymal Transition

by Freinkman, Elizaveta, Comb, William C, Cantor, Jason R, Tam, Wai Leong, Thiru, Prathapan, Kanarek, Naama, Bierie, Brian, Shaul, Yoav, Kim, Dohoon, Chen, Walter W., Possemato, Richard, Reinhardt, Ferenc, Weinberg, Robert A, Yaffe, Michael B, Sabatini, David, Pacold, Michael Edward
Published 2017

Growth signaling at the nexus of stem cell life and death

by Wood, Kris C., Sabatini, David
Published 2009

High-fat diet enhances stemness and tumorigenicity of intestinal progenitors

by Saadatpour, Assieh, Hong, Sue-Jean, Pinello, Luca, Katz, Yarden, Lamming, Dudley W., Guo, Guoji, Bell, George W., Selig, Martin, Nielsen, G. Petur, Gupta, Nitin, Ferrone, Cristina R., Deshpande, Vikram, Yuan, Guo-Cheng, Orkin, Stuart H., Beyaz, Semir, Mana, Miyeko, Roper, Jatin, Kedrin, Dmitriy, Bauer-Rowe, Khristian E., Xifaras, Michael, Akkad, Adam, Arias, Erika, Shinagare, Shweta, Abu-Remaileh, Monther, Dogum, Rizkullah, Sabatini, David, Yilmaz, Omer, Mihaylova, Maria M.
Published 2017

RNA Bind-n-Seq: Quantitative Assessment of the Sequence and Structural Binding Specificity of RNA Binding Proteins

by Lambert, Nicole, Robertson, Alex De Jong, Jangi, Mohini Rohit, McGeary, Sean Edward, Sharp, Phillip A., Burge, Christopher B.
Published 2017

The bromodomain protein Brd4 insulates chromatin from DNA damage signalling

by Floyd, Scott R., Pacold, Michael E., Huang, Qiuying, Clarke, Scott M., Rameseder, Jonathan, Lee, Michael J., Blake, Emily J., Fydrych, Anna, Ho, Richard, Del Rosario, Amanda M., Root, David E., Carpenter, Anne E., Hahn, William C., Sabatini, David M., Chen, Clark C., White, Forest M., Bradner, James E., Yaffe, Michael B., Lam, Fred Chiu-Lai, Cannell, Ian Gordon, Bryson, Bryan D., Greenberger, Benjamin Aaron, Chen, Grace, Maffa, Amanda D.
Published 2014

Hierarchical Organization Endows the Kinase Domain with Regulatory Plasticity

by Creixell, Pau, Pandey, Jai P., Creixell, Marc, Pincus, David, Yaffe, Michael B.
Published 2020

Genes methylated by DNA methyltransferase 3b are similar in mouse intestine and human colon cancer

by Steine, Eveline J., Ehrich, Mathias, Bell, George W., Raj, Arjun, Reddy, Seshamma, van Oudenaarden, Alexander, Jaenisch, Rudolf, Linhart, Heinz G.
Published 2012

Perturbation of m6A Writers Reveals Two Distinct Classes of mRNA Methylation at Internal and 5' Sites

by Schwartz, Schraga, Mumbach, Maxwell R, Jovanovic, Marko, Wang, Tim, Maciag, Karolina, Bushkin, G. Guy, Mertins, Philipp, Ter-Ovanesyan, Dmitry, Habib, Naomi, Cacchiarelli, Davide, Sanjana, Neville E, Freinkman, Elizaveta, Pacold, Michael E., Satija, Rahul, Hacohen, Nir, Zhang, Feng, Regev, Aviv, Mikkelsen, Tarjei Sigurd 1978-, Carr, Steven A, Lander, Eric Steven
Published 2015

A Pleiotropically Acting MicroRNA, miR-31, Inhibits Breast Cancer Metastasis

by Valastyan, Scott John, Reinhardt, Ferenc, Benaich, Nathan, Calogrias, Diana, Szász, Attila M., Wang, Zhigang C., Brock, Jane E., Richardson, Andrea L., Nathan Benaich, Weinberg, Robert A
Published 2015

Genetic Screens in Human Cells Using the CRISPR-Cas9 System

by Wang, Tim, Wei, Jenny J., Sabatini, David, Lander, Eric Steven
Published 2015

Cancer Cell of Origin: Spotlight on Luminal Progenitors

by Chaffer, Christine L., Weinberg, Robert A
Published 2015

A Radical Role for TOR in Longevity

by Lamming, Dudley W, Sabatini, David M, Sabatini, David
Published 2014