The evolution of drug resistance in clinical isolates of Candida albicans

by Christopher B Ford, Jason M Funt, Darren Abbey, Luca Issi, Candace Guiducci, Diego A Martinez, Toni Delorey, Bi yu Li, Theodore C White, Christina Cuomo, Reeta P Rao, Judith Berman, Dawn A Thompson, Aviv Regev
Published 2015-02-01

Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

by Jeffrey L. Bessen, Lena K. Afeyan, Vlado Dančík, Luke W. Koblan, David B. Thompson, Chas Leichner, Paul A. Clemons, David R. Liu
Published 2019-07-01

The landscape of chromosomal aberrations in breast cancer mouse models reveals driver-specific routes to tumorigenesis

by Uri Ben-David, Gavin Ha, Prasidda Khadka, Xin Jin, Bang Wong, Lude Franke, Todd R. Golub
Published 2016-07-01

Advancing neuropsychiatric genetics training and collaboration in Africa

by Celia van der Merwe, Emmanuel K Mwesiga, Nathaniel W McGregor, Abebe Ejigu, Abigiya Wondimagegnehu Tilahun, Allan Kalungi, Benedict Akimana, Benyam Worku Dubale, Felicita Omari, Jackline Mmochi, Lerato Majara, Linnet Ongeri, Melkam Alemayehu, Nastassja Koen, Shareefa Dalvie, Symon M Kariuki, Michelle Hoogenhout
Published 2018-03-01

CREB5 Promotes Resistance to Androgen-Receptor Antagonists and Androgen Deprivation in Prostate Cancer

by Justin H. Hwang, Ji-Heui Seo, Michael L. Beshiri, Stephanie Wankowicz, David Liu, Alexander Cheung, Ji Li, Xintao Qiu, Andrew L. Hong, Ginevra Botta, Lior Golumb, Camden Richter, Jonathan So, Gabriel J. Sandoval, Andrew O. Giacomelli, Seav Huong Ly, Celine Han, Chao Dai, Hubert Pakula, Anjali Sheahan, Federica Piccioni, Ole Gjoerup, Massimo Loda, Adam G. Sowalsky, Leigh Ellis, Henry Long, David E. Root, Kathleen Kelly, Eliezer M. Van Allen, Matthew L. Freedman, Atish D. Choudhury, William C. Hahn
Published 2019-11-01

Systematic auditing is essential to debiasing machine learning in biology

by Fatma-Elzahraa Eid, Haitham A. Elmarakeby, Yujia Alina Chan, Nadine Fornelos, Mahmoud ElHefnawi, Eliezer M. Van Allen, Lenwood S. Heath, Kasper Lage
Published 2021-02-01

Resolving cell state in iPSC-derived human neural samples with multiplexed fluorescence imaging

by Martin L. Tomov, Alison O’Neil, Hamdah S. Abbasi, Beth A. Cimini, Anne E. Carpenter, Lee L. Rubin, Mark Bathe
Published 2021-06-01

Integrating evolutionary and regulatory information with a multispecies approach implicates genes and pathways in obsessive-compulsive disorder

by Hyun Ji Noh, Ruqi Tang, Jason Flannick, Colm O’Dushlaine, Ross Swofford, Daniel Howrigan, Diane P. Genereux, Jeremy Johnson, Gerard van Grootheest, Edna Grünblatt, Erik Andersson, Diana R. Djurfeldt, Paresh D. Patel, Michele Koltookian, Christina M. Hultman, Michele T. Pato, Carlos N. Pato, Steven A. Rasmussen, Michael A. Jenike, Gregory L. Hanna, S. Evelyn Stewart, James A. Knowles, Stephan Ruhrmann, Hans-Jörgen Grabe, Michael Wagner, Christian Rück, Carol A. Mathews, Susanne Walitza, Daniëlle C. Cath, Guoping Feng, Elinor K. Karlsson, Kerstin Lindblad-Toh
Published 2017-10-01

Resistance to checkpoint blockade therapy through inactivation of antigen presentation

by Moshe Sade-Feldman, Yunxin J. Jiao, Jonathan H. Chen, Michael S. Rooney, Michal Barzily-Rokni, Jean-Pierre Eliane, Stacey L. Bjorgaard, Marc R. Hammond, Hans Vitzthum, Shauna M. Blackmon, Dennie T. Frederick, Mehlika Hazar-Rethinam, Brandon A. Nadres, Emily E. Van Seventer, Sachet A. Shukla, Keren Yizhak, John P. Ray, Daniel Rosebrock, Dimitri Livitz, Viktor Adalsteinsson, Gad Getz, Lyn M. Duncan, Bo Li, Ryan B. Corcoran, Donald P. Lawrence, Anat Stemmer-Rachamimov, Genevieve M. Boland, Dan A. Landau, Keith T. Flaherty, Ryan J. Sullivan, Nir Hacohen
Published 2017-10-01

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

by Willmen Youngsaye, Cathy L. Hartland, Barbara J. Morgan, Amal Ting, Partha P. Nag, Benjamin Vincent, Carrie A. Mosher, Joshua A. Bittker, Sivaraman Dandapani, Michelle Palmer, Luke Whitesell, Susan Lindquist, Stuart L. Schreiber, Benito Munoz
Published 2013-07-01

BLISS is a versatile and quantitative method for genome-wide profiling of DNA double-strand breaks

by Winston X. Yan, Reza Mirzazadeh, Silvano Garnerone, David Scott, Martin W. Schneider, Tomasz Kallas, Joaquin Custodio, Erik Wernersson, Yinqing Li, Linyi Gao, Yana Federova, Bernd Zetsche, Feng Zhang, Magda Bienko, Nicola Crosetto
Published 2017-05-01

Orthogonal translation enables heterologous ribosome engineering in E. coli

by Natalie S. Kolber, Ranan Fattal, Sinisa Bratulic, Gavriela D. Carver, Ahmed H. Badran
Published 2021-01-01

High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases

by Jeffrey L. Bessen, Lena K. Afeyan, Vlado Dančík, Luke W. Koblan, David B. Thompson, Chas Leichner, Paul A. Clemons, David R. Liu
Published 2019-04-01

BarkBase: Epigenomic Annotation of Canine Genomes

by Kate Megquier, Diane P. Genereux, Jessica Hekman, Ross Swofford, Jason Turner-Maier, Jeremy Johnson, Jacob Alonso, Xue Li, Kathleen Morrill, Lynne J. Anguish, Michele Koltookian, Brittney Logan, Claire R. Sharp, Lluis Ferrer, Kerstin Lindblad-Toh, Vicki N. Meyers-Wallen, Andrew Hoffman, Elinor K. Karlsson
Published 2019-06-01

Polygenic adaptation on height is overestimated due to uncorrected stratification in genome-wide association studies

by Mashaal Sohail, Robert M Maier, Andrea Ganna, Alex Bloemendal, Alicia R Martin, Michael C Turchin, Charleston WK Chiang, Joel Hirschhorn, Mark J Daly, Nick Patterson, Benjamin Neale, Iain Mathieson, David Reich, Shamil R Sunyaev
Published 2019-03-01

Paternal-age-related de novo mutations and risk for five disorders

by Jacob L. Taylor, Jean-Christophe P. G. Debost, Sarah U. Morton, Emilie M. Wigdor, Henrike O. Heyne, Dennis Lal, Daniel P. Howrigan, Alex Bloemendal, Janne T. Larsen, Jack A. Kosmicki, Daniel J. Weiner, Jason Homsy, Jonathan G. Seidman, Christine E. Seidman, Esben Agerbo, John J. McGrath, Preben Bo Mortensen, Liselotte Petersen, Mark J. Daly, Elise B. Robinson
Published 2019-07-01

A Scaled Framework for CRISPR Editing of Human Pluripotent Stem Cells to Study Psychiatric Disease

by Dane Z. Hazelbaker, Amanda Beccard, Anne M. Bara, Nicole Dabkowski, Angelica Messana, Patrizia Mazzucato, Daisy Lam, Danielle Manning, Kevin Eggan, Lindy E. Barrett
Published 2017-10-01

Clonal evolution in patients with chronic lymphocytic leukaemia developing resistance to BTK inhibition

by Jan A. Burger, Dan A. Landau, Amaro Taylor-Weiner, Ivana Bozic, Huidan Zhang, Kristopher Sarosiek, Lili Wang, Chip Stewart, Jean Fan, Julia Hoellenriegel, Mariela Sivina, Adrian M. Dubuc, Cameron Fraser, Yulong Han, Shuqiang Li, Kenneth J. Livak, Lihua Zou, Youzhong Wan, Sergej Konoplev, Carrie Sougnez, Jennifer R. Brown, Lynne V. Abruzzo, Scott L. Carter, Michael J. Keating, Matthew S. Davids, William G. Wierda, Kristian Cibulskis, Thorsten Zenz, Lillian Werner, Paola Dal Cin, Peter Kharchencko, Donna Neuberg, Hagop Kantarjian, Eric Lander, Stacey Gabriel, Susan O’Brien, Anthony Letai, David A. Weitz, Martin A. Nowak, Gad Getz, Catherine J. Wu
Published 2016-05-01

Engineering designer beta cells with a CRISPR-Cas9 conjugation platform

by Donghyun Lim, Vedagopuram Sreekanth, Kurt J. Cox, Benjamin K. Law, Bridget K. Wagner, Jeffrey M. Karp, Amit Choudhary
Published 2020-08-01

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment

by James E Gomez, Benjamin B Kaufmann-Malaga, Carl N Wivagg, Peter B Kim, Melanie R Silvis, Nikolai Renedo, Thomas R Ioerger, Rushdy Ahmad, Jonathan Livny, Skye Fishbein, James C Sacchettini, Steven A Carr, Deborah T Hung
Published 2017-02-01