Rare genomic structural variants in complex disease: lessons from the replication of associations with obesity.

by Robin G Walters, Lachlan J M Coin, Aimo Ruokonen, Adam J de Smith, Julia S El-Sayed Moustafa, Sebastien Jacquemont, Paul Elliott, Tõnu Esko, Anna-Liisa Hartikainen, Jaana Laitinen, Katrin Männik, Danielle Martinet, David Meyre, Matthias Nauck, Claudia Schurmann, Rob Sladek, Gudmar Thorleifsson, Unnur Thorsteinsdóttir, Armand Valsesia, Gerard Waeber, Flore Zufferey, Beverley Balkau, François Pattou, Andres Metspalu, Henry Völzke, Peter Vollenweider, Kári Stefansson, Marjo-Riitta Järvelin, Jacques S Beckmann, Philippe Froguel, Alexandra I F Blakemore
Published 2013-01-01

Genetic variants associated with platelet count are predictive of human disease and physiological markers

by Evgenia Mikaelsdottir, Gudmar Thorleifsson, Lilja Stefansdottir, Gisli Halldorsson, Jon K. Sigurdsson, Sigrun H. Lund, Vinicius Tragante, Pall Melsted, Solvi Rognvaldsson, Kristjan Norland, Anna Helgadottir, Magnus K. Magnusson, Gunnar B. Ragnarsson, Sigurdur Y. Kristinsson, Sigrun Reykdal, Brynjar Vidarsson, Ingibjorg J. Gudmundsdottir, Isleifur Olafsson, Pall T. Onundarson, Olof Sigurdardottir, Emil L. Sigurdsson, Gerdur Grondal, Arni J. Geirsson, Gudmundur Geirsson, Julius Gudmundsson, Hilma Holm, Saedis Saevarsdottir, Ingileif Jonsdottir, Gudmundur Thorgeirsson, Daniel F. Gudbjartsson, Unnur Thorsteinsdottir, Thorunn Rafnar, Kari Stefansson
Published 2021-09-01

Eleven genomic loci affect plasma levels of chronic inflammation marker soluble urokinase-type plasminogen activator receptor

by Joseph Dowsett, Egil Ferkingstad, Line Jee Hartmann Rasmussen, Lise Wegner Thørner, Magnús K. Magnússon, Karen Sugden, Gudmar Thorleifsson, Mike Frigge, Kristoffer Sølvsten Burgdorf, Sisse Rye Ostrowski, Erik Sørensen, Christian Erikstrup, Ole Birger Pedersen, Thomas Folkmann Hansen, Karina Banasik, Søren Brunak, DBDS Genomic Consortium, Vinicius Tragante, Sigrun Helga Lund, Lilja Stefansdottir, Bjarni Gunnarson, Richie Poulton, Louise Arseneault, Avshalom Caspi, Terrie E. Moffitt, Daníel Gudbjartsson, Jesper Eugen-Olsen, Hreinn Stefánsson, Kári Stefánsson, Henrik Ullum
Published 2021-06-01

A genome-wide meta-analysis uncovers six sequence variants conferring risk of vertigo

by Astros Th. Skuladottir, Gyda Bjornsdottir, Muhammad Sulaman Nawaz, Hannes Petersen, Solvi Rognvaldsson, Kristjan Helgi Swerford Moore, Pall I. Olafsson, Sigurður H. Magnusson, Anna Bjornsdottir, Olafur A. Sveinsson, Gudrun R. Sigurdardottir, Saedis Saevarsdottir, Erna V. Ivarsdottir, Lilja Stefansdottir, Bjarni Gunnarsson, Joseph B. Muhlestein, Kirk U. Knowlton, David A. Jones, Lincoln D. Nadauld, Annette M. Hartmann, Dan Rujescu, Michael Strupp, G. Bragi Walters, Thorgeir E. Thorgeirsson, Ingileif Jonsdottir, Hilma Holm, Gudmar Thorleifsson, Daniel F. Gudbjartsson, Patrick Sulem, Hreinn Stefansson, Kari Stefansson
Published 2021-10-01

Eighty-eight variants highlight the role of T cell regulation and airway remodeling in asthma pathogenesis

by Thorunn A. Olafsdottir, Fannar Theodors, Kristbjorg Bjarnadottir, Unnur Steina Bjornsdottir, Arna B. Agustsdottir, Olafur A. Stefansson, Erna V. Ivarsdottir, Jon K. Sigurdsson, Stefania Benonisdottir, Gudmundur I. Eyjolfsson, David Gislason, Thorarinn Gislason, Steinunn Guðmundsdóttir, Arnaldur Gylfason, Bjarni V. Halldorsson, Gisli H. Halldorsson, Thorhildur Juliusdottir, Anna M. Kristinsdottir, Dora Ludviksdottir, Bjorn R. Ludviksson, Gisli Masson, Kristjan Norland, Pall T. Onundarson, Isleifur Olafsson, Olof Sigurdardottir, Lilja Stefansdottir, Gardar Sveinbjornsson, Vinicius Tragante, Daniel F. Gudbjartsson, Gudmar Thorleifsson, Patrick Sulem, Unnur Thorsteinsdottir, Gudmundur L. Norddahl, Ingileif Jonsdottir, Kari Stefansson
Published 2020-01-01

A meta-analysis uncovers the first sequence variant conferring risk of Bell’s palsy

by Astros Th. Skuladottir, Gyda Bjornsdottir, Gudmar Thorleifsson, G. Bragi Walters, Muhammad Sulaman Nawaz, Kristjan Helgi Swerford Moore, Pall I. Olason, Thorgeir E. Thorgeirsson, Brynja Sigurpalsdottir, Gardar Sveinbjornsson, Hannes P. Eggertsson, Sigurdur H. Magnusson, Asmundur Oddsson, Anna Bjornsdottir, Arnor Vikingsson, Olafur A. Sveinsson, Maria G. Hrafnsdottir, Gudrun R. Sigurdardottir, Bjarni V. Halldorsson, Thomas Folkmann Hansen, Helene Paarup, Christian Erikstrup, Kaspar Nielsen, Mads Klokker, Mie Topholm Bruun, Erik Sorensen, Karina Banasik, Kristoffer S. Burgdorf, Ole Birger Pedersen, Henrik Ullum, Ingileif Jonsdottir, Hreinn Stefansson, Kari Stefansson
Published 2021-02-01

Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits

by Thorunn Rafnar, Bjarni Gunnarsson, Olafur A. Stefansson, Patrick Sulem, Andres Ingason, Michael L. Frigge, Lilja Stefansdottir, Jon K. Sigurdsson, Vinicius Tragante, Valgerdur Steinthorsdottir, Unnur Styrkarsdottir, Simon N. Stacey, Julius Gudmundsson, Gudny A. Arnadottir, Asmundur Oddsson, Florian Zink, Gisli Halldorsson, Gardar Sveinbjornsson, Ragnar P. Kristjansson, Olafur B. Davidsson, Anna Salvarsdottir, Asgeir Thoroddsen, Elisabet A. Helgadottir, Katrin Kristjansdottir, Orri Ingthorsson, Valur Gudmundsson, Reynir T. Geirsson, Ragnheidur Arnadottir, Daniel F. Gudbjartsson, Gisli Masson, Folkert W. Asselbergs, Jon G. Jonasson, Karl Olafsson, Unnur Thorsteinsdottir, Bjarni V. Halldorsson, Gudmar Thorleifsson, Kari Stefansson
Published 2018-09-01

Large genome-wide association study identifies three novel risk variants for restless legs syndrome

by Maria Didriksen, Muhammad Sulaman Nawaz, Joseph Dowsett, Steven Bell, Christian Erikstrup, Ole B. Pedersen, Erik Sørensen, Poul J. Jennum, Kristoffer S. Burgdorf, Brendan Burchell, Adam S. Butterworth, Nicole Soranzo, David B. Rye, Lynn Marie Trotti, Prabhjyot Saini, Lilja Stefansdottir, Sigurdur H. Magnusson, Gudmar Thorleifsson, Thordur Sigmundsson, Albert P. Sigurdsson, Katja Van Den Hurk, Franke Quee, Michael W. T. Tanck, Willem H. Ouwehand, David J. Roberts, Eric J. Earley, Michael P. Busch, Alan E. Mast, Grier P. Page, John Danesh, Emanuele Di Angelantonio, Hreinn Stefansson, Henrik Ullum, Kari Stefansson
Published 2020-11-01

Genome-wide analysis yields new loci associating with aortic valve stenosis

by Anna Helgadottir, Gudmar Thorleifsson, Solveig Gretarsdottir, Olafur A. Stefansson, Vinicius Tragante, Rosa B. Thorolfsdottir, Ingileif Jonsdottir, Thorsteinn Bjornsson, Valgerdur Steinthorsdottir, Niek Verweij, Jonas B. Nielsen, Wei Zhou, Lasse Folkersen, Andreas Martinsson, Mahyar Heydarpour, Siddharth Prakash, Gylfi Oskarsson, Tomas Gudbjartsson, Arnar Geirsson, Isleifur Olafsson, Emil L. Sigurdsson, Peter Almgren, Olle Melander, Anders Franco-Cereceda, Anders Hamsten, Lars Fritsche, Maoxuan Lin, Bo Yang, Whitney Hornsby, Dongchuan Guo, Chad M. Brummett, Gonçalo Abecasis, Michael Mathis, Dianna Milewicz, Simon C. Body, Per Eriksson, Cristen J. Willer, Kristian Hveem, Christopher Newton-Cheh, J. Gustav Smith, Ragnar Danielsen, Gudmundur Thorgeirsson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hilma Holm, Kari Stefansson
Published 2018-03-01

A genome-wide association study yields five novel thyroid cancer risk loci

by Julius Gudmundsson, Gudmar Thorleifsson, Jon K. Sigurdsson, Lilja Stefansdottir, Jon G. Jonasson, Sigurjon A. Gudjonsson, Daniel F. Gudbjartsson, Gisli Masson, Hrefna Johannsdottir, Gisli H. Halldorsson, Simon N. Stacey, Hannes Helgason, Patrick Sulem, Leigha Senter, Huiling He, Sandya Liyanarachchi, Matthew D. Ringel, Esperanza Aguillo, Angeles Panadero, Enrique Prats, Almudena Garcia-Castaño, Ana De Juan, Fernando Rivera, Li Xu, Lambertus A. Kiemeney, Gudmundur I. Eyjolfsson, Olof Sigurdardottir, Isleifur Olafsson, Hoskuldur Kristvinsson, Romana T. Netea-Maier, Thorvaldur Jonsson, Jose I. Mayordomo, Theo S. Plantinga, Hannes Hjartarson, Jon Hrafnkelsson, Erich M. Sturgis, Unnur Thorsteinsdottir, Thorunn Rafnar, Albert de la Chapelle, Kari Stefansson
Published 2017-02-01

The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but not all cohorts.

by Helen N Lyon, Valur Emilsson, Anke Hinney, Iris M Heid, Jessica Lasky-Su, Xiaofeng Zhu, Gudmar Thorleifsson, Steinunn Gunnarsdottir, G Bragi Walters, Unnur Thorsteinsdottir, Augustine Kong, Jeffrey Gulcher, Thuy Trang Nguyen, André Scherag, Arne Pfeufer, Thomas Meitinger, Günter Brönner, Winfried Rief, Manuel E Soto-Quiros, Lydiana Avila, Barbara Klanderman, Benjamin A Raby, Edwin K Silverman, Scott T Weiss, Nan Laird, Xiao Ding, Leif Groop, Tiinamaija Tuomi, Bo Isomaa, Kristina Bengtsson, Johannah L Butler, Richard S Cooper, Caroline S Fox, Christopher J O'Donnell, Caren Vollmert, Juan C Celedón, H Erich Wichmann, Johannes Hebebrand, Kari Stefansson, Christoph Lange, Joel N Hirschhorn
Published 2007-04-01

Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism

by Yadav Sapkota, Valgerdur Steinthorsdottir, Andrew P. Morris, Amelie Fassbender, Nilufer Rahmioglu, Immaculata De Vivo, Julie E. Buring, Futao Zhang, Todd L. Edwards, Sarah Jones, Dorien O, Daniëlle Peterse, Kathryn M. Rexrode, Paul M. Ridker, Andrew J. Schork, Stuart MacGregor, Nicholas G. Martin, Christian M. Becker, Sosuke Adachi, Kosuke Yoshihara, Takayuki Enomoto, Atsushi Takahashi, Yoichiro Kamatani, Koichi Matsuda, Michiaki Kubo, Gudmar Thorleifsson, Reynir T. Geirsson, Unnur Thorsteinsdottir, Leanne M. Wallace, iPSYCH-SSI-Broad Group, Jian Yang, Digna R. Velez Edwards, Mette Nyegaard, Siew-Kee Low, Krina T. Zondervan, Stacey A. Missmer, Thomas D'Hooghe, Grant W. Montgomery, Daniel I. Chasman, Kari Stefansson, Joyce Y. Tung, Dale R. Nyholt
Published 2017-05-01

Geographic differences in genetic susceptibility to IgA nephropathy: GWAS replication study and geospatial risk analysis.

by Krzysztof Kiryluk, Yifu Li, Simone Sanna-Cherchi, Mersedeh Rohanizadegan, Hitoshi Suzuki, Frank Eitner, Holly J Snyder, Murim Choi, Ping Hou, Francesco Scolari, Claudia Izzi, Maddalena Gigante, Loreto Gesualdo, Silvana Savoldi, Antonio Amoroso, Daniele Cusi, Pasquale Zamboli, Bruce A Julian, Jan Novak, Robert J Wyatt, Krzysztof Mucha, Markus Perola, Kati Kristiansson, Alexander Viktorin, Patrik K Magnusson, Gudmar Thorleifsson, Unnur Thorsteinsdottir, Kari Stefansson, Anne Boland, Marie Metzger, Lise Thibaudin, Christoph Wanner, Kitty J Jager, Shin Goto, Dita Maixnerova, Hussein H Karnib, Judit Nagy, Ulf Panzer, Jingyuan Xie, Nan Chen, Vladimir Tesar, Ichiei Narita, Francois Berthoux, Jürgen Floege, Benedicte Stengel, Hong Zhang, Richard P Lifton, Ali G Gharavi
Published 2012-01-01

Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.

by Felix Day, Tugce Karaderi, Michelle R Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H Mullin, Bronwyn G A Stuckey, Timothy D Spector, Scott G Wilson, Mark O Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G Uitterlinden, Verneri Anttila, Benjamin M Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S Legro, Andres Salumets, Mark I McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, 23andMe Research Team, Unnur Styrkarsdottir, John R B Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M Lindgren, Corrine K Welt
Published 2018-12-01

Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.

by Emma L Duncan, Patrick Danoy, John P Kemp, Paul J Leo, Eugene McCloskey, Geoffrey C Nicholson, Richard Eastell, Richard L Prince, John A Eisman, Graeme Jones, Philip N Sambrook, Ian R Reid, Elaine M Dennison, John Wark, J Brent Richards, Andre G Uitterlinden, Tim D Spector, Chris Esapa, Roger D Cox, Steve D M Brown, Rajesh V Thakker, Kathryn A Addison, Linda A Bradbury, Jacqueline R Center, Cyrus Cooper, Catherine Cremin, Karol Estrada, Dieter Felsenberg, Claus-C Glüer, Johanna Hadler, Margaret J Henry, Albert Hofman, Mark A Kotowicz, Joanna Makovey, Sing C Nguyen, Tuan V Nguyen, Julie A Pasco, Karena Pryce, David M Reid, Fernando Rivadeneira, Christian Roux, Kari Stefansson, Unnur Styrkarsdottir, Gudmar Thorleifsson, Rumbidzai Tichawangana, David M Evans, Matthew A Brown
Published 2011-04-01

Fourteen sequence variants that associate with multiple sclerosis discovered by meta-analysis informed by genetic correlations

by Sigurgeir Olafsson, Pernilla Stridh, Steffan Daniël Bos, Andres Ingason, Jack Euesden, Patrick Sulem, Gudmar Thorleifsson, Omar Gustafsson, Ari Johannesson, Arni J. Geirsson, Arni V. Thorsson, Bardur Sigurgeirsson, Bjorn Runar Ludviksson, Elias Olafsson, Helga Kristjansdottir, Jon G. Jonasson, Jon Hjaltalin Olafsson, Kjartan B. Orvar, Rafn Benediktsson, Ragnar Bjarnason, Sjofn Kristjansdottir, Thorarinn Gislason, Trausti Valdimarsson, Evgenia Mikaelsdottir, Snaevar Sigurdsson, Stefan Jonsson, Thorunn Rafnar, Dag Aarsland, Srdjan Djurovic, Tormod Fladby, Gun Peggy Knudsen, Elisabeth G. Celius, Kjell-Morten Myhr, Gerdur Grondal, Kristjan Steinsson, Helgi Valdimarsson, Sigurdur Bjornsson, Unnur S. Bjornsdottir, Einar S Bjornsson, Bjorn Nilsson, Ole A. Andreassen, Lars Alfredsson, Jan Hillert, Ingrid Skelton Kockum, Gisli Masson, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Hreinn Stefansson, Haukur Hjaltason, Hanne F. Harbo, Tomas Olsson, Ingileif Jonsdottir, Kari Stefansson
Published 2017-08-01

Correction: Large-scale genome-wide meta-analysis of polycystic ovary syndrome suggests shared genetic architecture for different diagnosis criteria.

by Felix Day, Tugce Karaderi, Michelle R Jones, Cindy Meun, Chunyan He, Alex Drong, Peter Kraft, Nan Lin, Hongyan Huang, Linda Broer, Reedik Magi, Richa Saxena, Triin Laisk, Margrit Urbanek, M Geoffrey Hayes, Gudmar Thorleifsson, Juan Fernandez-Tajes, Anubha Mahajan, Benjamin H Mullin, Bronwyn G A Stuckey, Timothy D Spector, Scott G Wilson, Mark O Goodarzi, Lea Davis, Barbara Obermayer-Pietsch, André G Uitterlinden, Verneri Anttila, Benjamin M Neale, Marjo-Riitta Jarvelin, Bart Fauser, Irina Kowalska, Jenny A Visser, Marianne Andersen, Ken Ong, Elisabet Stener-Victorin, David Ehrmann, Richard S Legro, Andres Salumets, Mark I McCarthy, Laure Morin-Papunen, Unnur Thorsteinsdottir, Kari Stefansson, 23andMe Research Team, Unnur Styrkarsdottir, John R B Perry, Andrea Dunaif, Joop Laven, Steve Franks, Cecilia M Lindgren, Corrine K Welt
Published 2019-12-01

GWAS of thyroid stimulating hormone highlights pleiotropic effects and inverse association with thyroid cancer

by Wei Zhou, Ben Brumpton, Omer Kabil, Julius Gudmundsson, Gudmar Thorleifsson, Josh Weinstock, Matthew Zawistowski, Jonas B. Nielsen, Layal Chaker, Marco Medici, Alexander Teumer, Silvia Naitza, Serena Sanna, Ulla T. Schultheiss, Anne Cappola, Juha Karjalainen, Mitja Kurki, Morgan Oneka, Peter Taylor, Lars G. Fritsche, Sarah E. Graham, Brooke N. Wolford, William Overton, Humaira Rasheed, Eirin B. Haug, Maiken E. Gabrielsen, Anne Heidi Skogholt, Ida Surakka, George Davey Smith, Anita Pandit, Tanmoy Roychowdhury, Whitney E. Hornsby, Jon G. Jonasson, Leigha Senter, Sandya Liyanarachchi, Matthew D. Ringel, Li Xu, Lambertus A. Kiemeney, Huiling He, Romana T. Netea-Maier, Jose I. Mayordomo, Theo S. Plantinga, Jon Hrafnkelsson, Hannes Hjartarson, Erich M. Sturgis, Aarno Palotie, Mark Daly, Cintia E. Citterio, Peter Arvan, Chad M. Brummett, Michael Boehnke, Albert de la Chapelle, Kari Stefansson, Kristian Hveem, Cristen J. Willer, Bjørn Olav Åsvold
Published 2020-08-01

Publisher Correction: GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures

by Unnur Styrkarsdottir, Olafur A. Stefansson, Kristbjorg Gunnarsdottir, Gudmar Thorleifsson, Sigrun H. Lund, Lilja Stefansdottir, Kristinn Juliusson, Arna B. Agustsdottir, Florian Zink, Gisli H. Halldorsson, Erna V. Ivarsdottir, Stefania Benonisdottir, Hakon Jonsson, Arnaldur Gylfason, Kristjan Norland, Katerina Trajanoska, Cindy G. Boer, Lorraine Southam, Jason C. S. Leung, Nelson L. S. Tang, Timothy C. Y. Kwok, Jenny S. W. Lee, Suzanne C. Ho, Inger Byrjalsen, Jacqueline R. Center, Seung Hun Lee, Jung-Min Koh, L. Stefan Lohmander, Lan T. Ho-Pham, Tuan V. Nguyen, John A. Eisman, Jean Woo, Ping-C. Leung, John Loughlin, Eleftheria Zeggini, Claus Christiansen, Fernando Rivadeneira, Joyce van Meurs, Andre G. Uitterlinden, Brynjolfur Mogensen, Helgi Jonsson, Thorvaldur Ingvarsson, Gunnar Sigurdsson, Rafn Benediktsson, Patrick Sulem, Ingileif Jonsdottir, Gisli Masson, Hilma Holm, Gudmundur L. Norddahl, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Kari Stefansson
Published 2019-05-01

GWAS of bone size yields twelve loci that also affect height, BMD, osteoarthritis or fractures

by Unnur Styrkarsdottir, Olafur A. Stefansson, Kristbjorg Gunnarsdottir, Gudmar Thorleifsson, Sigrun H. Lund, Lilja Stefansdottir, Kristinn Juliusson, Arna B. Agustsdottir, Florian Zink, Gisli H. Halldorsson, Erna V. Ivarsdottir, Stefania Benonisdottir, Hakon Jonsson, Arnaldur Gylfason, Kristjan Norland, Katerina Trajanoska, Cindy G. Boer, Lorraine Southam, Jason C. S. Leung, Nelson L. S. Tang, Timothy C. Y. Kwok, Jenny S. W. Lee, Suzanne C. Ho, Inger Byrjalsen, Jacqueline R. Center, Seung Hun Lee, Jung-Min Koh, L. Stefan Lohmander, Lan T. Ho-Pham, Tuan V. Nguyen, John A. Eisman, Jean Woo, Ping-C. Leung, John Loughlin, Eleftheria Zeggini, Claus Christiansen, Fernando Rivadeneira, Joyce van Meurs, Andre G. Uitterlinden, Brynjolfur Mogensen, Helgi Jonsson, Thorvaldur Ingvarsson, Gunnar Sigurdsson, Rafn Benediktsson, Patrick Sulem, Ingileif Jonsdottir, Gisli Masson, Hilma Holm, Gudmundur L. Norddahl, Unnur Thorsteinsdottir, Daniel F. Gudbjartsson, Kari Stefansson
Published 2019-05-01