EGLN1 Inhibition and Rerouting of α-Ketoglutarate Suffice for Remote Ischemic Protection

by Olenchock, Benjamin A, Moslehi, Javid, Baik, Alan H, Williams, Jeremy, Gibson, William J, Chakraborty, Abhishek A, Pierce, Kerry A, Miller, Christine M, Hanse, Eric A, Kelekar, Ameeta, Wagers, Amy J, Clish, Clary B, Kaelin, William G, Davidson, Shawn M, Sullivan, Lucas Bryan, Vander Heiden, Matthew G.
Published 2017

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

by Olivares, Orianne, Mayers, Jared R., Gouirand, Victoire, Torrence, Margaret E., Gicquel, Tristan, Borge, Laurence, Lac, Sophie, Roques, Julie, Lavaut, Marie-Noëlle, Berthezène, Patrice, Rubis, Marion, Secq, Veronique, Garcia, Stéphane, Moutardier, Vincent, Lombardo, Dominique, Iovanna, Juan Lucio, Tomasini, Richard, Guillaumond, Fabienne, Vander Heiden, Matthew G., Vasseur, Sophie
Published 2018

Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer

by Sayin, Volkan I, LeBoeuf, Sarah E, Singh, Simranjit X, Biancur, Douglas, Guzelhan, Betul S, Alvarez, Samantha W, Wu, Warren L, Karakousi, Triantafyllia R, Zavitsanou, Anastasia Maria, Ubriaco, Julian, Karagiannis, Dimitris, Morris, Patrick J, Thomas, Craig J, Possemato, Richard, Papagiannakopoulos, Thales, Davidson, Shawn M, Muir, Alexander, Vander Heiden, Matthew G.
Published 2018

Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation

by Tech, Katherine, Tikunov, Andrey P., Farooq, Hamza, Morrissy, A. Sorana, Meidinger, Jessica, Fish, Taylor, Green, Sarah C., Liu, Hedi, Li, Yisu, Mungall, Andrew J., Moore, Richard A., Ma, Yussanne, Jones, Steven J.M, Marra, Marco A., Vander Heiden, Matthew G., Taylor, Michael D., Macdonald, Jeffrey M., Gershon, Timothy R.
Published 2018

Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers

by Ji, B. W., Dixit, P. D., Wolpin, B. M., Vitkup, D., Mayers, Jared R., Torrence, Margaret E., Danai, Laura V., Papagiannakopoulos, Thales, Davidson, Shawn M., Bauer, Matthew R., Lau, Allison N., Hosios, Aaron Marc, Muir, Alexander, Chin, Christopher R., Freinkman, Elizaveta, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2018

IDH1 Mutations Alter Citric Acid Cycle Metabolism and Increase Dependence on Oxidative Mitochondrial Metabolism

by Grassian, A. R., Parker, S. J., Divakaruni, A. S., Green, C. R., Zhang, X., Slocum, K. L., Pu, M., Lin, F., Vickers, C., Joud-Caldwell, C., Chung, F., Yin, H., Handly, E. D., Straub, C., Growney, J. D., Murphy, A. N., Pagliarini, R., Metallo, C. M., Davidson, Shawn M, Vander Heiden, Matthew G.
Published 2016

A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate

by Chan, Sze Ham, Lewis, Caroline, Swier, Lotteke J. Y. M., Chen, Walter W., Sullivan, Lucas Bryan, Fiske, Brian Prescott, Cho, Sung Won, Abu-Remaileh, Monther, Liu, Chieh Ming Jamin, Zhou, Minerva H., Koh, Min Jung, Chung, Haeyoon, Davidson, Shawn M, Luengo, Alba, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Published 2017

SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance

by Kami, Kenjiro, Shelton, Laura M., Ramkissoon, Shakti H., Ligon, Keith L., Snuderl, Matija, Kim, Dohoon, Fiske, Brian Prescott, Birsoy, Kivanc, Freinkman, Elizaveta, Possemato, Richard, Chudnovsky, Yakov, Chen, Walter W., Cantor, Jason R., Gui, Dan Yi, Kwon, ManJae, Kang, Seong Woo, Vander Heiden, Matthew G., Sabatini, David, Pacold, Michael Edward
Published 2017

Global Transcriptional and Translational Repression in Human-Embryonic-Stem-Cell-Derived Rett Syndrome Neurons

by Li, Yun, Wang, Haoyi, Muffat, Julien, Cheng, Albert W, Orlando, David A., Feldman, Danielle A, Bateup, Helen S, Gao, Qing, Hockemeyer, Dirk, Mitalipova, Maisam, Lewis, Caroline A, Sur, Mriganka, Young, Richard A, Jaenisch, Rudolf, Loven, Jakob, Vander Heiden, Matthew G., Feldman, Danielle A., Young, Richard A., Lewis, Caroline, Kwok, Show Ming
Published 2016

Keap1 mutation renders lung adenocarcinomas dependent on Slc33a1

by Romero, Rodrigo, Sánchez-Rivera, Francisco J, Westcott, Peter MK, Mercer, Kim L, Bhutkar, Arjun, Muir, Alexander, González Robles, Tania J, Lamboy Rodríguez, Swanny, Liao, Laura Z, Ng, Sheng Rong, Li, Leanne, Colón, Caterina I, Naranjo, Santiago, Beytagh, Mary Clare, Lewis, Caroline A, Hsu, Peggy P, Bronson, Roderick T, Vander Heiden, Matthew G, Jacks, Tyler
Published 2021

Targeting MTHFD2 in acute myeloid leukemia

by Pikman, Yana, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Banerji, Versha, Stegmaier, Kimberly, Puissant, Alexandre, Lewis, Caroline, Ramos, Azucena, Hemann, Michael, Vander Heiden, Matthew G.
Published 2017

Targeting MTHFD2 in acute myeloid leukemia

by Pikman, Yana, Puissant, Alexandre, Alexe, Gabriela, Furman, Andrew, Chen, Liying M., Frumm, Stacey M., Ross, Linda, Fenouille, Nina, Bassil, Christopher F., Lewis, Caroline, Ramos, Azucena, Gould, Joshua, Stone, Richard M., DeAngelo, Daniel J., Galinsky, Ilene, Clish, Clary B., Kung, Andrew L., Hemann, Michael, Vander Heiden, Matthew G., Banerji, Versha, Stegmaier, Kimberly
Published 2022

Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism

by Fendt, Sarah-Maria, Bell, Eric L., Keibler, Mark Andrew, Davidson, Shawn Michael, Wirth, Gregory J., Fiske, Brian Prescott, Mayers, Jared R., Schwab, Matthias, Bellinger, Gary, Csibi, Alfred, Patnaik, Akash, Blouin, Marie Jose, Cantley, Lewis C., Guarente, Leonard Pershing, Blenis, John, Pollak, Michael N., Olumi, Aria F., Vander Heiden, Matthew G., Stephanopoulos, Gregory
Published 2014

Metabolic Regulation of Protein N-Alpha-Acetylation by Bcl-xL Promotes Cell Survival

by Yi, Caroline H, Pan, Heling, Seebacher, Jan, Jang, Il-Ho, Hyberts, Sven G, Heffron, Gregory J., Vander Heiden, Matthew G, Yang, Renliang, Li, Fupeng, Locasale, Jason W., Sharfi, Hadar, Zhai, Bo, Rodriguez-Mias, Ricard, Luithardt, Harry, Cantley, Lewis C., Daley, George Q., Asara, John M., Gygi, Steven P., Wagner, Gerhard, Liu, Chuan-Fa, Yuan, Junying
Published 2014

Direct evidence for cancer-cell-autonomous extracellular protein catabolism in pancreatic tumors

by Kellersberger, Katherine A, Stall, Brian K, Stephanopoulos, Gregory, Bar-Sagi, Dafna, Han, Jongyoon, Rabinowitz, Joshua D, Davidson, Shawn M, Jonas, Oliver H., Keibler, Mark Andrew, Hou, Han Wei, Luengo, Alba, Mayers, Jared R., Wyckoff, Jeffrey, Del Rosario, Amanda M, Whitman, Matthew A, Condon, Kendall Janine, Lammers, Alex A, Langer, Robert S, Vander Heiden, Matthew G., Cima, Michael J.
Published 2018

Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer

by Papagiannakopoulos, Thales, Olenchock, Benjamin A, Heyman, Julia E, Jha, Abhishek K, Pierce, Kerry A, Mott, Bryan T, Clish, Clary B, Davidson, Shawn M., Luengo, Alba, Bauer, Matthew R., Keibler, Mark Andrew, O'Brien, James P., Gui, Dan Yi, Sullivan, Lucas Bryan, Wasylenko, Thomas Michael, Subbaraj, Lakshmipriya, Chin, Christopher R., Stephanopolous, Gregory, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2018

Development of a Colon Cancer GEMM-Derived Orthotopic Transplant Model for Drug Discovery and Validation

by Martin, Eric S., Belmont, P. J., Sinnamon, M. J., Richard, L. G., Yuan, J., Coffee, E. M., Roper, J., Lee, L., Heidari, P., Goel, G., Ji, X., Xie, Z., Xie, T., Lamb, J., Weinrich, S. L., VanArsdale, T., Bronson, Roderick T., Xavier, R. J., Kan, J. L. C., Mahmood, Umar, Hung, Kenneth E., Lunt, Sophia Yunkyungkwon, Vander Heiden, Matthew G.
Published 2015

JAK2/IDH-mutant-driven myeloproliferative neoplasm is sensitive to combined targeted inhibition

by McKenney, Anna Sophia, Somasundara, Amritha Varshini Hanasoge, Spitzer, Barbara, Intlekofer, Andrew M., Ahn, Jihae, Shank, Kaitlyn, Rapaport, Franck T., Patel, Minal A., Papalexi, Efthymia, Chiu, April, Freinkman, Elizaveta, Akbay, Esra A., Steadman, Mya, Nagaraja, Raj, Yen, Katharine, Teruya-Feldstein, Julie, Wong, Kwok-Kin, Rampal, Raajit, Levine, Ross L., Lau, Allison N., Shihadeh, Alan, Vander Heiden, Matthew G., Thompson, Craig B., Levine, Ross L
Published 2018

Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth

by Cox, Andrew G, Tsomides, Allison, Yimlamai, Dean, Hwang, Katie L, Miesfeld, Joel, Galli, Giorgio G, Fowl, Brendan H, Fort, Michael, Ma, Kimberly Y, Sullivan, Mark R, Hosios, Aaron M, Snay, Erin, Yuan, Min, Brown, Kristin K, Lien, Evan C, Chhangawala, Sagar, Steinhauser, Matthew L, Asara, John M, Houvras, Yariv, Link, Brian, Vander Heiden, Matthew G, Camargo, Fernando D, Goessling, Wolfram
Published 2020

PKM2 Isoform-Specific Deletion Reveals a Differential Requirement for Pyruvate Kinase in Tumor Cells

by Li, Jie, Sasaki, Mika, Horner, James W, Burga, Laura N, Xie, Jianxin, Jurczak, Michael J, DePinho, Ronald A, Clish, Clary B, Kibbey, Richard G, Wulf, Gerburg M, Di Vizio, Dolores, Mills, Gordon B, Cantley, Lewis C, Israelsen, William James, Dayton, Talya L., Davidson, Shawn M., Fiske, Brian Prescott, Hosios, Aaron Marc, Bellinger, Gary, Yu, Yimin, Jacks, Tyler E., Vander Heiden, Matthew G.
Published 2017