A CREB3-ARF4 signalling pathway mediates the response to Golgi stress and susceptibility to pathogens

by Reiling, Jan H., Olive, Andrew J., Sanyal, Sumana, Carette, Jan E., Brummelkamp, Thijn R., Starnbach, Michael N., Ploegh, Hidde, Sabatini, David
Published 2015

Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids

by Sancak, Yasemin, Bar-Peled, Liron, Zoncu, Roberto, Markhard, Andrew L., Nada, Shigeyuki, Sabatini, David
Published 2012

Discovery of 1-(4-(4-Propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a Highly Potent, Selective Mammalian Target of Rapa...

by Liu, Qingsong, Chang, Jae Won, Wang, Jinhua, Kang, Seong A., Thoreen, Carson C., Markhard, Andrew L., Hur, Wooyoung, Zhang, Jianming, Sim, Taebo, Gray, Nathanael S., Sabatini, David
Published 2014

Inhibition of ATPIF1 Ameliorates Severe Mitochondrial Respiratory Chain Dysfunction in Mammalian Cells

by Chen, Walter W., Mihaylova, Maria M., Snitkin, Harriet, Stasinski, Iwona, Yucel, Burcu, Bayraktar, Erol C., Carette, Jan E., Clish, Clary, Brummelkamp, Thijn R., Sabatini, David M, Birsoy, Kivanc
Published 2015

Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity

by Chaffer, Christine L, Marjanovic, Nemanja D, Lee, Tony, Bell, George, Kleer, Celina G, Reinhardt, Ferenc, D'Alessio, Ana C, Young, Richard A, Weinberg, Robert A, Young, Richard A., Weinberg, Robert A
Published 2016

Reactive metabolite production is a targetable liability of glycolytic metabolism in lung cancer

by Luengo, Alba, Abbott, Keene L., Davidson, Shawn M., Hosios, Aaron M., Chan, Sze Ham, Freinkman, Elizaveta, Lewis, Caroline A., Vander Heiden, Matthew G.
Published 2020

Rapamycin Doses Sufficient to Extend Lifespan Do Not Compromise Muscle Mitochondrial Content or Endurance

by Ye, Lan, Widlund, Anne L., Sims, Carrie A., Lamming, Dudley W., Guan, Yuxia, Davis, James G., Harrison, David E., Vang, Ole, Baur, Joseph A., Sabatini, David
Published 2015

Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity

by Caron, Alexandre, Labbé, Sébastien M., Lanfray, Damien, Blanchard, Pierre-Gilles, Villot, Romain, Roy, Christian, Richard, Denis, Laplante, Mathieu, Sabatini, David
Published 2016

Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium

by Pentinmikko, Nalle, Iqbal, Sharif, Mana, Miyeko, Andersson, Simon, Cognetta, Armand B., Suciu, Radu M., Roper, Jatin, Luopajärvi, Kalle, Markelin, Eino, Gopalakrishnan, Swetha, Smolander, Olli-Pekka, Naranjo, Santiago, Saarinen, Tuure, Juuti, Anne, Pietiläinen, Kirsi, Auvinen, Petri, Ristimäki, Ari, Gupta, Nitin, Tammela, Tuomas, Jacks, Tyler E, Sabatini, David, Cravatt, Benjamin F., Yilmaz, Ömer H., Katajisto, Pekka
Published 2020

mTOR Complex 1 Regulates Lipin 1 Localization to Control the SREBP Pathway

by Peterson, Timothy R, Sengupta, Shomit S, Harris, Thurl E, Carpenter, Anne E., Kang, Seong A., Balderas, Eric, Guertin, David A., Madden, Katherine L., Finck, Brian N, Sabatini, David M, Kang, Seong A., Peterson, Timothy Richard, Sengupta, Shomit, Sabatini, David
Published 2014

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

by Spooner, Eric, Tsun, Zhi-Yang, Bar-Peled, Liron, Chantranupong, Lynne, Zoncu, Roberto, Wang, Tim, Kim, Choah, Sabatini, David
Published 2017

Regulation of Centromere Localization of the Drosophila Shugoshin MEI-S332 and Sister-Chromatid Cohesion in Meiosis

by Nogueira, C., Kashevsky, Helena, Clarke, A., Pinto, Belinda Sophia, Orr-Weaver, Terry
Published 2015

The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism

by Lamming, Dudley W., Soliman, Mohamed A., Abdel Rahman, Anas M., Birsoy, Kivanc, Pawling, Judy, Frigolet, Maria E., Lu, Huogen, Fantus, I. George, Pasculescu, Adrian, Zheng, Yong, Dennis, James W., Pawson, Tony, Sabatini, David
Published 2015

Identification and characterization of essential genes in the human genome

by Hughes, N. W., Wang, Tim, Birsoy, Kivanc, Krupczak, Kevin M., Post, Yorick, Lander, Eric Steven, Sabatini, David, Wei, Jenny J.
Published 2017

Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1

by Sandy, Peter, Meylan, Etienne, Reiling, Jan H., Hoersch, Sebastian, Barbie, David A., Tamayo, Pablo, Boehm, Jesse S., Kim, So Young, Moody, Susan E., Dunn, Ian F., Schinzel, Anna C., Scholl, Claudia, Frohling, Stefan, Chan, Edmond M., Sos, Martin L., Michel, Kathrin, Mermel, Craig H., Sabatini, David, Lander, Eric Steven, Jacks, Tyler E
Published 2014

Densely Interconnected Transcriptional Circuits Control Cell States in Human Hematopoiesis

by Novershtern, Noa, Subramanian, Aravind, Lawton, Lee N., Mak, Raymond H., Haining, W. Nicholas, McConkey, Marie, Habib, Naomi, Yosef, Nir, Chang, Cindy Y., Shay, Tal, Frampton, Garrett M., Leskov, Ilya B., Nilsson, Bjorn, Preffer, Fred, Dombkowski, David, Evans, John W., Liefeld, Ted, Smutko, John S., Chen, Jianzhu, Friedman, Nir, Young, Richard A., Golub, Todd R., Regev, Aviv, Ebert, Benjamin L., Drake, Adam
Published 2014

Serine Catabolism by SHMT2 Is Required for Proper Mitochondrial Translation Initiation and Maintenance of Formylmethionyl-tRNAs

by Sabatini, David M.
Published 2020

mTORC1 Phosphorylation Sites Encode Their Sensitivity to Starvation and Rapamycin

by Cervantes, Christopher L., Lim, Daniel Cham-Chin, Kang, Seong A., Pacold, Michael E., Lou, Hua Jane, Ottina, Kathleen, Gray, Nathanael S., Turk, Benjamin E., Yaffe, Michael B, Sabatini, David
Published 2014

A Diverse Array of Cancer-Associated MTOR Mutations Are Hyperactivating and Can Predict Rapamycin Sensitivity

by Grabiner, Brian C., Nardi, Valentina, Birsoy, Kivanc, Possemato, Richard, Shen, Kuang, Sinha, Sumi, Jordan, Alexander, Beck, Andrew H., Sabatini, David
Published 2015

A haploid genetic screen identifies the major facilitator domain containing 2A (MFSD2A) transporter as a key mediator in the response to tunicamycin

by Reiling, Jan H., Clish, Clary, Carette, Jan E., Varadarajan, Malini, Brummelkamp, Thijn R., Sabatini, David
Published 2012