TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer’s Disease: Lessons Learned from Transcriptomics

by Feng Xue, Heng Du
Published 2021-02-01

Therapeutic Trem2 activation ameliorates amyloid-beta deposition and improves cognition in the 5XFAD model of amyloid deposition

by Brittani R. Price, Tiffany L. Sudduth, Erica M. Weekman, Sherika Johnson, Danielle Hawthorne, Abigail Woolums, Donna M. Wilcock
Published 2020-08-01

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriers

by Jorge L. Del-Aguila, Bruno A. Benitez, Zeran Li, Umber Dube, Kathie A. Mihindukulasuriya, John P. Budde, Fabiana H. G. Farias, Maria Victoria Fernández, Laura Ibanez, Shan Jiang, Richard J. Perrin, Nigel J. Cairns, John C. Morris, Oscar Harari, Carlos Cruchaga
Published 2019-05-01

TREM2 Regulates High Glucose-Induced Microglial Inflammation via the NLRP3 Signaling Pathway

by Yuan Li, Weihong Long, Menghan Gao, Fangtai Jiao, Zecai Chen, Mingyuan Liu, Lu Yu
Published 2021-07-01

Nuevos genes descubiertos relacionados con la Enfermedad de Alzheimer

by Gabriel Cruz Díaz, Diana Citlali García Plata
Published 2013-12-01

THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency

by Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelmans
Published 2021-07-01

Microglial TREM2 Mitigates Inflammatory Responses and Neuronal Apoptosis in Angiotensin II-Induced Hypertension in Middle-Aged Mice

by Xiaotian Xu, Xiaotian Xu, Lin Du, Jianxiong Jiang, Ming Yang, Zhaoxia Wang, Yingge Wang, Tieyu Tang, Xuetao Fu, Jiukuan Hao
Published 2021-08-01

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

by Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer's Disease Neuroimaging Initiative
Published 2018-12-01

Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model

by Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan, Wen Wu
Published 2020-10-01

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

by Honghua Zheng, Honghua Zheng, Baoying Cheng, Yanfang Li, Yanfang Li, Xin Li, Xiaofen Chen, Xiaofen Chen, Yun-wu Zhang
Published 2018-11-01

The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke

by Pascal Gervois, Ivo Lambrichts
Published 2019-07-01

TREM2 deficiency exacerbates tau pathology through dysregulated kinase signaling in a mouse model of tauopathy

by Shane M. Bemiller, Tyler J. McCray, Kevin Allan, Shane V. Formica, Guixiang Xu, Gina Wilson, Olga N. Kokiko-Cochran, Samuel D. Crish, Cristian A. Lasagna-Reeves, Richard M. Ransohoff, Gary E. Landreth, Bruce T. Lamb
Published 2017-10-01

TREM2-Dependent Effects on Microglia in Alzheimer’s Disease

by Yingyue Zhou, Tyler K. Ulland, Marco Colonna
Published 2018-07-01

TREM2 protects against cerebral ischemia/reperfusion injury

by Rong Wu, Xiangpen Li, Pengfei Xu, Likui Huang, Jinping Cheng, Xiaolong Huang, Jingru Jiang, Long-Jun Wu, Yamei Tang
Published 2017-06-01

TREM2, Driving the Microglial Polarization, Has a TLR4 Sensitivity Profile After Subarachnoid Hemorrhage

by Yangchun Hu, Chao Li, Xiaojian Wang, Weiwei Chen, Yu Qian, Xingliang Dai
Published 2021-08-01

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation

by Michael Ewers, Gloria Biechele, Marc Suárez‐Calvet, Christian Sacher, Tanja Blume, Estrella Morenas‐Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Matthias Brendel, Christian Haass, Nicolai Franzmeier
Published 2020-09-01

Function of TREM1 and TREM2 in Liver-Related Diseases

by Huifang Sun, Jianguo Feng, Liling Tang
Published 2020-12-01

Microglia in Alzheimer's Disease: Risk Factors and Inflammation

by Atsuko Katsumoto, Hideyuki Takeuchi, Keita Takahashi, Fumiaki Tanaka
Published 2018-11-01

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

by Shengpan Chen, Jianhua Peng, Prativa Sherchan, Yongjie Ma, Sishi Xiang, Feng Yan, Hao Zhao, Yong Jiang, Ning Wang, John H. Zhang, Hongqi Zhang
Published 2020-05-01

Microglia: Agents of the CNS Pro-Inflammatory Response

by José A. Rodríguez-Gómez, Edel Kavanagh, Pinelopi Engskog-Vlachos, Mikael K.R. Engskog, Antonio J. Herrera, Ana M. Espinosa-Oliva, Bertrand Joseph, Nabil Hajji, José L. Venero, Miguel A. Burguillos
Published 2020-07-01