Derivation of cutoffs for the Elecsys® amyloid β (1–42) assay in Alzheimer's disease

by Leslie M. Shaw, Teresa Waligorska, Leona Fields, Magdalena Korecka, Michal Figurski, John Q. Trojanowski, Udo Eichenlaub, Simone Wahl, Marian Quan, Michael J. Pontecorvo, D. Richard Lachno, Jayne A. Talbot, Scott W. Andersen, Eric R. Siemers, Robert A. Dean
Published 2018-01-01

Frontotemporal lobar degeneration proteinopathies have disparate microscopic patterns of white and grey matter pathology

by Lucia A. A. Giannini, Claire Peterson, Daniel Ohm, Sharon X. Xie, Corey T. McMillan, Katya Raskovsky, Lauren Massimo, EunRah Suh, Vivianna M. Van Deerlin, David A. Wolk, John Q. Trojanowski, Edward B. Lee, Murray Grossman, David J. Irwin
Published 2021-02-01

An HDAC6-dependent surveillance mechanism suppresses tau-mediated neurodegeneration and cognitive decline

by Hanna Trzeciakiewicz, Deepa Ajit, Jui-Heng Tseng, Youjun Chen, Aditi Ajit, Zarin Tabassum, Rebecca Lobrovich, Claire Peterson, Natallia V. Riddick, Michelle S. Itano, Ashutosh Tripathy, Sheryl S. Moy, Virginia M. Y. Lee, John Q. Trojanowski, David J. Irwin, Todd J. Cohen
Published 2020-11-01

Characterization of tau binding by gosuranemab

by Richelle Sopko, Olga Golonzhka, Joseph Arndt, Chao Quan, Julie Czerkowicz, Andrew Cameron, Benjamin Smith, Yogapriya Murugesan, Garrett Gibbons, Soo-Jung Kim, John Q. Trojanowski, Virginia M.Y. Lee, Kurt R. Brunden, Danielle L. Graham, Paul H. Weinreb, Heike Hering
Published 2020-12-01

Characterization of Parkinson's disease using blood-based biomarkers: A multicohort proteomic analysis.

by Marijan Posavi, Maria Diaz-Ortiz, Benjamine Liu, Christine R Swanson, R Tyler Skrinak, Pilar Hernandez-Con, Defne A Amado, Michelle Fullard, Jacqueline Rick, Andrew Siderowf, Daniel Weintraub, Leo McCluskey, John Q Trojanowski, Richard B Dewey, Xuemei Huang, Alice S Chen-Plotkin
Published 2019-10-01

Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration

by Ahmed Yousef, John L. Robinson, David J. Irwin, Matthew D. Byrne, Linda K. Kwong, Edward B. Lee, Yan Xu, Sharon X. Xie, Lior Rennert, EunRan Suh, Vivianna M. Van Deerlin, Murray Grossman, Virginia M.-Y. Lee, John Q. Trojanowski
Published 2017-09-01

Higher CSF sTREM2 and microglia activation are associated with slower rates of beta‐amyloid accumulation

by Michael Ewers, Gloria Biechele, Marc Suárez‐Calvet, Christian Sacher, Tanja Blume, Estrella Morenas‐Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, the Alzheimer's Disease Neuroimaging Initiative (ADNI), Matthias Brendel, Christian Haass, Nicolai Franzmeier
Published 2020-09-01

Characterization of novel conformation-selective α-synuclein antibodies as potential immunotherapeutic agents for Parkinson's disease

by Michael X. Henderson, Dustin J. Covell, Charlotte Hiu-Yan Chung, Rose M. Pitkin, Raizel M. Sandler, Samantha C. Decker, Dawn M. Riddle, Bin Zhang, Ronald J. Gathagan, Michael J. James, John Q. Trojanowski, Kurt R. Brunden, Virginia M.Y. Lee, Kelvin C. Luk
Published 2020-03-01

Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice

by Eve Peeraer, Astrid Bottelbergs, Kristof Van Kolen, Ilie-Cosmin Stancu, Bruno Vasconcelos, Michel Mahieu, Hilde Duytschaever, Luc Ver Donck, An Torremans, Ellen Sluydts, Nathalie Van Acker, John A. Kemp, Marc Mercken, Kurt R. Brunden, John Q. Trojanowski, Ilse Dewachter, Virginia M.Y. Lee, Diederik Moechars
Published 2015-01-01

Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD

by Shanshan Wang, Joseph S. Leem, Sonia Podvin, Vivian Hook, Natalia Kleschevnikov, Paul Savchenko, Mehul Dhanani, Kimberly Zhou, Isabella C. Kelly, Tong Zhang, Atsushi Miyanohara, Phuong Nguyen, Alexander Kleschevnikov, Steve L. Wagner, John Q. Trojanowski, David M. Roth, Hemal H. Patel, Piyush M. Patel, Brian P. Head
Published 2021-06-01

Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration

by Katrina L. Paumier, Kelvin C. Luk, Fredric P. Manfredsson, Nicholas M. Kanaan, Jack W. Lipton, Timothy J. Collier, Kathy Steece-Collier, Christopher J. Kemp, Stephanie Celano, Emily Schulz, Ivette M. Sandoval, Sheila Fleming, Elliott Dirr, Nicole K. Polinski, John Q. Trojanowski, Virginia M. Lee, Caryl E. Sortwell
Published 2015-10-01

The MAPT H1c risk haplotype is associated with increased expression of tau and especially of 4 repeat containing transcripts

by Amanda J. Myers, Alan M. Pittman, Alice S. Zhao, Kristen Rohrer, Mona Kaleem, Lauren Marlowe, Andrew Lees, Doris Leung, Ian G. McKeith, Robert H. Perry, Chris M. Morris, John Q. Trojanowski, Christopher Clark, Jason Karlawish, Steve Arnold, Mark S. Forman, Vivianna Van Deerlin, Rohan de Silva, John Hardy
Published 2007-03-01

Association analysis of rare variants near the APOE region with CSF and neuroimaging biomarkers of Alzheimer’s disease

by Kwangsik Nho, Sungeun Kim, Emrin Horgusluoglu, Shannon L. Risacher, Li Shen, Dokyoon Kim, Seunggeun Lee, Tatiana Foroud, Leslie M. Shaw, John Q. Trojanowski, Paul S. Aisen, Ronald C. Petersen, Clifford R. Jack, Michael W. Weiner, Robert C. Green, Arthur W. Toga, Andrew J. Saykin, for the Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Published 2017-05-01

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

by Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M. Karch, Carlos Cruchaga, Leslie M. Shaw, John Q. Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, for the Alzheimer’s Disease Neuroimaging Initiative
Published 2019-01-01

Influence of genetic variation on plasma protein levels in older adults using a multi-analyte panel.

by Sungeun Kim, Shanker Swaminathan, Mark Inlow, Shannon L Risacher, Kwangsik Nho, Li Shen, Tatiana M Foroud, Ronald C Petersen, Paul S Aisen, Holly Soares, Jon B Toledo, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Brenna C McDonald, Martin R Farlow, Bernardino Ghetti, Andrew J Saykin, Alzheimer’s Disease Neuroimaging Initiative (ADNI)
Published 2013-01-01

The Role of Apolipoprotein E (APOE) Genotype in Early Mild Cognitive Impairment (E-MCI)

by Shannon L Risacher, Sungeun eKim, Sungeun eKim, Li eShen, Li eShen, Kwangsik eNho, Tatiana eForoud, Robert C Green, Ronald C Petersen, Clifford R Jack, Paul S Aisen, Robert A Koeppe, William J Jagust, Leslie M Shaw, John Q Trojanowski, Michael W Weiner, Michael W Weiner, Andrew J Saykin
Published 2013-04-01

Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease.

by Chelsea Caspell-Garcia, Tanya Simuni, Duygu Tosun-Turgut, I-Wei Wu, Yu Zhang, Mike Nalls, Andrew Singleton, Leslie A Shaw, Ju-Hee Kang, John Q Trojanowski, Andrew Siderowf, Christopher Coffey, Shirley Lasch, Dag Aarsland, David Burn, Lana M Chahine, Alberto J Espay, Eric D Foster, Keith A Hawkins, Irene Litvan, Irene Richard, Daniel Weintraub, Parkinson’s Progression Markers Initiative (PPMI)
Published 2017-01-01

Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models.

by Sethu Sankaranarayanan, Donna M Barten, Laurel Vana, Nino Devidze, Ling Yang, Gregory Cadelina, Nina Hoque, Lynn DeCarr, Stefanie Keenan, Alan Lin, Yang Cao, Bradley Snyder, Bin Zhang, Magdalena Nitla, Gregg Hirschfeld, Nestor Barrezueta, Craig Polson, Paul Wes, Vangipuram S Rangan, Angela Cacace, Charles F Albright, Jere Meredith, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunden, Michael Ahlijanian
Published 2015-01-01

Predictors of cognitive impairment in primary age-related tauopathy: an autopsy study

by Megan A. Iida, Kurt Farrell, Jamie M. Walker, Timothy E. Richardson, Gabriel A. Marx, Clare H. Bryce, Dushyant Purohit, Gai Ayalon, Thomas G. Beach, Eileen H. Bigio, Etty P. Cortes, Marla Gearing, Vahram Haroutunian, Corey T. McMillan, Edward B. Lee, Dennis W. Dickson, Ann C. McKee, Thor D. Stein, John Q. Trojanowski, Randall L. Woltjer, Gabor G. Kovacs, Julia K. Kofler, Jeffrey Kaye, Charles L. White, John F. Crary
Published 2021-08-01

CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration and cognitive decline

by Marc Suárez‐Calvet, Anja Capell, Miguel Ángel Araque Caballero, Estrella Morenas‐Rodríguez, Katrin Fellerer, Nicolai Franzmeier, Gernot Kleinberger, Erden Eren, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Katrina Paumier, Randall J Bateman, Anne M Fagan, John C Morris, Johannes Levin, Adrian Danek, Mathias Jucker, Colin L Masters, Martin N Rossor, John M Ringman, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haass, the Dominantly Inherited Alzheimer Network, the Alzheimer's Disease Neuroimaging Initiative
Published 2018-12-01